Case Report: A Metabolic Complete Response to Upfront Osimertinib in a Smoker Non-Small Cell Lung Cancer Patient Harbouring EGFR G719A/V769M Complex Mutation

Complex EGFR mutations are rare in non-small cell lung cancer (NSCLC). Limited clinical evidence is available on the efficacy of EGFR tyrosine kinase inhibitors (TKIs) in patients with NSCLC harbouring these uncommon EGFR mutations. Here, we reported the case of a complete metabolic response in a pa...

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Autores principales: Simionato, Francesca, Calvetti, Lorenzo, Cosci, Marco, Scarparo, Silvia, Aprile, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695685/
https://www.ncbi.nlm.nih.gov/pubmed/33262603
http://dx.doi.org/10.2147/OTT.S280933
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author Simionato, Francesca
Calvetti, Lorenzo
Cosci, Marco
Scarparo, Silvia
Aprile, Giuseppe
author_facet Simionato, Francesca
Calvetti, Lorenzo
Cosci, Marco
Scarparo, Silvia
Aprile, Giuseppe
author_sort Simionato, Francesca
collection PubMed
description Complex EGFR mutations are rare in non-small cell lung cancer (NSCLC). Limited clinical evidence is available on the efficacy of EGFR tyrosine kinase inhibitors (TKIs) in patients with NSCLC harbouring these uncommon EGFR mutations. Here, we reported the case of a complete metabolic response in a patient with advanced NSCLC carrying the uncommon EGFR G719A/V769M complex mutation treated with the first-line osimertinib.
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spelling pubmed-76956852020-11-30 Case Report: A Metabolic Complete Response to Upfront Osimertinib in a Smoker Non-Small Cell Lung Cancer Patient Harbouring EGFR G719A/V769M Complex Mutation Simionato, Francesca Calvetti, Lorenzo Cosci, Marco Scarparo, Silvia Aprile, Giuseppe Onco Targets Ther Case Report Complex EGFR mutations are rare in non-small cell lung cancer (NSCLC). Limited clinical evidence is available on the efficacy of EGFR tyrosine kinase inhibitors (TKIs) in patients with NSCLC harbouring these uncommon EGFR mutations. Here, we reported the case of a complete metabolic response in a patient with advanced NSCLC carrying the uncommon EGFR G719A/V769M complex mutation treated with the first-line osimertinib. Dove 2020-11-23 /pmc/articles/PMC7695685/ /pubmed/33262603 http://dx.doi.org/10.2147/OTT.S280933 Text en © 2020 Simionato et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Simionato, Francesca
Calvetti, Lorenzo
Cosci, Marco
Scarparo, Silvia
Aprile, Giuseppe
Case Report: A Metabolic Complete Response to Upfront Osimertinib in a Smoker Non-Small Cell Lung Cancer Patient Harbouring EGFR G719A/V769M Complex Mutation
title Case Report: A Metabolic Complete Response to Upfront Osimertinib in a Smoker Non-Small Cell Lung Cancer Patient Harbouring EGFR G719A/V769M Complex Mutation
title_full Case Report: A Metabolic Complete Response to Upfront Osimertinib in a Smoker Non-Small Cell Lung Cancer Patient Harbouring EGFR G719A/V769M Complex Mutation
title_fullStr Case Report: A Metabolic Complete Response to Upfront Osimertinib in a Smoker Non-Small Cell Lung Cancer Patient Harbouring EGFR G719A/V769M Complex Mutation
title_full_unstemmed Case Report: A Metabolic Complete Response to Upfront Osimertinib in a Smoker Non-Small Cell Lung Cancer Patient Harbouring EGFR G719A/V769M Complex Mutation
title_short Case Report: A Metabolic Complete Response to Upfront Osimertinib in a Smoker Non-Small Cell Lung Cancer Patient Harbouring EGFR G719A/V769M Complex Mutation
title_sort case report: a metabolic complete response to upfront osimertinib in a smoker non-small cell lung cancer patient harbouring egfr g719a/v769m complex mutation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695685/
https://www.ncbi.nlm.nih.gov/pubmed/33262603
http://dx.doi.org/10.2147/OTT.S280933
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