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Convalescent Plasma Therapy for Management of COVID-19: Perspectives and Deployment in the Current Global Pandemic

The world is striving against the severe crisis of the COVID-19 pandemic. Healthcare professionals are struggling to treat their patients based on nonspecific therapies. Amidst this uncertainty, convalescent plasma therapy (CPT) has appeared to be an interim adjuvant therapy for severely ill patient...

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Autores principales: Samad, Nandeeta, Sodunke, Temitayo Eniola, Banna, Hasan Al, Sapkota, Ashmita, Fatema, Aneeka Nawar, Iskandar, Katia, Jahan, Dilshad, Hardcastle, Timothy Craig, Nusrat, Tanzina, Chowdhury, Tajkera Sultana, Haque, Mainul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695687/
https://www.ncbi.nlm.nih.gov/pubmed/33262668
http://dx.doi.org/10.2147/RMHP.S281388
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author Samad, Nandeeta
Sodunke, Temitayo Eniola
Banna, Hasan Al
Sapkota, Ashmita
Fatema, Aneeka Nawar
Iskandar, Katia
Jahan, Dilshad
Hardcastle, Timothy Craig
Nusrat, Tanzina
Chowdhury, Tajkera Sultana
Haque, Mainul
author_facet Samad, Nandeeta
Sodunke, Temitayo Eniola
Banna, Hasan Al
Sapkota, Ashmita
Fatema, Aneeka Nawar
Iskandar, Katia
Jahan, Dilshad
Hardcastle, Timothy Craig
Nusrat, Tanzina
Chowdhury, Tajkera Sultana
Haque, Mainul
author_sort Samad, Nandeeta
collection PubMed
description The world is striving against the severe crisis of the COVID-19 pandemic. Healthcare professionals are struggling to treat their patients based on nonspecific therapies. Amidst this uncertainty, convalescent plasma therapy (CPT) has appeared to be an interim adjuvant therapy for severely ill patients of COVID-19 until long-term clinical trial treatment options are available. Considering the transfusion-related hazards, especially lung injuries and microbial transmission, where sensitivity is not ensured, rigorous trials should be conducted to determine this therapy’s efficacy. Moreover, the ratio of recovered cases to plasma donors is not satisfying, which questioning this therapy’s availability and accessibility. Although some countries are making the treatment free, the attributable cost mandates a justification for its suitability and sustainability. Our article aimed to review the published facts and findings of CPT’s effectiveness in lowering the mortality rate of COVID-19. This pandemic showed that healthcare systems worldwide need core reform. A unified global collaboration must align and coordinate to face the current pandemic and enhance world readiness for future outbreaks based on health equity and equality.
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spelling pubmed-76956872020-11-30 Convalescent Plasma Therapy for Management of COVID-19: Perspectives and Deployment in the Current Global Pandemic Samad, Nandeeta Sodunke, Temitayo Eniola Banna, Hasan Al Sapkota, Ashmita Fatema, Aneeka Nawar Iskandar, Katia Jahan, Dilshad Hardcastle, Timothy Craig Nusrat, Tanzina Chowdhury, Tajkera Sultana Haque, Mainul Risk Manag Healthc Policy Review The world is striving against the severe crisis of the COVID-19 pandemic. Healthcare professionals are struggling to treat their patients based on nonspecific therapies. Amidst this uncertainty, convalescent plasma therapy (CPT) has appeared to be an interim adjuvant therapy for severely ill patients of COVID-19 until long-term clinical trial treatment options are available. Considering the transfusion-related hazards, especially lung injuries and microbial transmission, where sensitivity is not ensured, rigorous trials should be conducted to determine this therapy’s efficacy. Moreover, the ratio of recovered cases to plasma donors is not satisfying, which questioning this therapy’s availability and accessibility. Although some countries are making the treatment free, the attributable cost mandates a justification for its suitability and sustainability. Our article aimed to review the published facts and findings of CPT’s effectiveness in lowering the mortality rate of COVID-19. This pandemic showed that healthcare systems worldwide need core reform. A unified global collaboration must align and coordinate to face the current pandemic and enhance world readiness for future outbreaks based on health equity and equality. Dove 2020-11-23 /pmc/articles/PMC7695687/ /pubmed/33262668 http://dx.doi.org/10.2147/RMHP.S281388 Text en © 2020 Samad et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Samad, Nandeeta
Sodunke, Temitayo Eniola
Banna, Hasan Al
Sapkota, Ashmita
Fatema, Aneeka Nawar
Iskandar, Katia
Jahan, Dilshad
Hardcastle, Timothy Craig
Nusrat, Tanzina
Chowdhury, Tajkera Sultana
Haque, Mainul
Convalescent Plasma Therapy for Management of COVID-19: Perspectives and Deployment in the Current Global Pandemic
title Convalescent Plasma Therapy for Management of COVID-19: Perspectives and Deployment in the Current Global Pandemic
title_full Convalescent Plasma Therapy for Management of COVID-19: Perspectives and Deployment in the Current Global Pandemic
title_fullStr Convalescent Plasma Therapy for Management of COVID-19: Perspectives and Deployment in the Current Global Pandemic
title_full_unstemmed Convalescent Plasma Therapy for Management of COVID-19: Perspectives and Deployment in the Current Global Pandemic
title_short Convalescent Plasma Therapy for Management of COVID-19: Perspectives and Deployment in the Current Global Pandemic
title_sort convalescent plasma therapy for management of covid-19: perspectives and deployment in the current global pandemic
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695687/
https://www.ncbi.nlm.nih.gov/pubmed/33262668
http://dx.doi.org/10.2147/RMHP.S281388
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