Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk prediction

Cancer risk is determined by a complex interplay of environmental and heritable factors. Polygenic risk scores (PRS) provide a personalized genetic susceptibility profile that may be leveraged for disease prediction. Using data from the UK Biobank (413,753 individuals; 22,755 incident cancer cases),...

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Detalles Bibliográficos
Autores principales: Kachuri, Linda, Graff, Rebecca E., Smith-Byrne, Karl, Meyers, Travis J., Rashkin, Sara R., Ziv, Elad, Witte, John S., Johansson, Mattias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695829/
https://www.ncbi.nlm.nih.gov/pubmed/33247094
http://dx.doi.org/10.1038/s41467-020-19600-4

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