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An unusual case of eosinophilic lung disease with multiple cyst formation
We report here an unusual case of eosinophilic necrotizing inflammation of the lung that mimicked chronic eosinophilic pneumonia. A 71-year-old man who lived in an unsanitary environment and was referred to our hospital with suspected pneumonia. Peripheral blood eosinophilia was observed, and comput...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695879/ https://www.ncbi.nlm.nih.gov/pubmed/33294360 http://dx.doi.org/10.1016/j.rmcr.2020.101300 |
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author | Nogawa, Hitomi Suzuki, Hiroki Kawabata, Yoshinori Ota, Takahito Yuki, Yoshihiko Katagiri, Yuji Hino, Toshihiko Yanagawa, Naoki Ueki, Shigeharu |
author_facet | Nogawa, Hitomi Suzuki, Hiroki Kawabata, Yoshinori Ota, Takahito Yuki, Yoshihiko Katagiri, Yuji Hino, Toshihiko Yanagawa, Naoki Ueki, Shigeharu |
author_sort | Nogawa, Hitomi |
collection | PubMed |
description | We report here an unusual case of eosinophilic necrotizing inflammation of the lung that mimicked chronic eosinophilic pneumonia. A 71-year-old man who lived in an unsanitary environment and was referred to our hospital with suspected pneumonia. Peripheral blood eosinophilia was observed, and computed tomography indicated extensive consolidation with multiple cystic lesions, mainly in the left lung. A histological analysis using video-assisted thoracic surgery revealed diffuse infiltration of inflammatory cells into the alveolar wall and massive accumulation of macrophages and eosinophils in the airspace. Many tiny eosinophilic abscesses were scattered through the tissue. These findings were more severe than those associated with chronic eosinophilic pneumonia. Immunostaining revealed the deposition of eosinophil granular protein and the presence of extracellular traps and Charcot–Leyden crystals, which suggested excessive eosinophil activation. Interestingly, the patient's symptoms and clinical findings gradually improved without treatment after admission. He was discharged to a clean residence and did not have a recurrence for 19 months. The observations suggest a hypersensitivity reaction to an environmental allergen and consequent multiple cyst formation in association with eosinophilic necrotizing inflammation, although further studies are warranted. |
format | Online Article Text |
id | pubmed-7695879 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-76958792020-12-07 An unusual case of eosinophilic lung disease with multiple cyst formation Nogawa, Hitomi Suzuki, Hiroki Kawabata, Yoshinori Ota, Takahito Yuki, Yoshihiko Katagiri, Yuji Hino, Toshihiko Yanagawa, Naoki Ueki, Shigeharu Respir Med Case Rep Case Report We report here an unusual case of eosinophilic necrotizing inflammation of the lung that mimicked chronic eosinophilic pneumonia. A 71-year-old man who lived in an unsanitary environment and was referred to our hospital with suspected pneumonia. Peripheral blood eosinophilia was observed, and computed tomography indicated extensive consolidation with multiple cystic lesions, mainly in the left lung. A histological analysis using video-assisted thoracic surgery revealed diffuse infiltration of inflammatory cells into the alveolar wall and massive accumulation of macrophages and eosinophils in the airspace. Many tiny eosinophilic abscesses were scattered through the tissue. These findings were more severe than those associated with chronic eosinophilic pneumonia. Immunostaining revealed the deposition of eosinophil granular protein and the presence of extracellular traps and Charcot–Leyden crystals, which suggested excessive eosinophil activation. Interestingly, the patient's symptoms and clinical findings gradually improved without treatment after admission. He was discharged to a clean residence and did not have a recurrence for 19 months. The observations suggest a hypersensitivity reaction to an environmental allergen and consequent multiple cyst formation in association with eosinophilic necrotizing inflammation, although further studies are warranted. Elsevier 2020-11-19 /pmc/articles/PMC7695879/ /pubmed/33294360 http://dx.doi.org/10.1016/j.rmcr.2020.101300 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Nogawa, Hitomi Suzuki, Hiroki Kawabata, Yoshinori Ota, Takahito Yuki, Yoshihiko Katagiri, Yuji Hino, Toshihiko Yanagawa, Naoki Ueki, Shigeharu An unusual case of eosinophilic lung disease with multiple cyst formation |
title | An unusual case of eosinophilic lung disease with multiple cyst formation |
title_full | An unusual case of eosinophilic lung disease with multiple cyst formation |
title_fullStr | An unusual case of eosinophilic lung disease with multiple cyst formation |
title_full_unstemmed | An unusual case of eosinophilic lung disease with multiple cyst formation |
title_short | An unusual case of eosinophilic lung disease with multiple cyst formation |
title_sort | unusual case of eosinophilic lung disease with multiple cyst formation |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695879/ https://www.ncbi.nlm.nih.gov/pubmed/33294360 http://dx.doi.org/10.1016/j.rmcr.2020.101300 |
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