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Predictive value of chest CT scoring in COVID-19 patients in Wuhan, China: A retrospective cohort study

BACKGROUND: Computed tomography (CT) findings of COVID-19 patients were demonstrated by cases series and descriptive studies, but quantitative analysis performed by clinical doctors and studies on its predictive value were rarely seen. The aim of the study is to analyze CT score in COVID-19 patients...

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Autores principales: Li, Shu, Liu, Shaoyu, Wang, Ben, Li, Qiuyu, Zhang, Hua, Zeng, Lin, Ge, Hongxia, Ma, Qingbian, Shen, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695948/
https://www.ncbi.nlm.nih.gov/pubmed/33296777
http://dx.doi.org/10.1016/j.rmed.2020.106271
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author Li, Shu
Liu, Shaoyu
Wang, Ben
Li, Qiuyu
Zhang, Hua
Zeng, Lin
Ge, Hongxia
Ma, Qingbian
Shen, Ning
author_facet Li, Shu
Liu, Shaoyu
Wang, Ben
Li, Qiuyu
Zhang, Hua
Zeng, Lin
Ge, Hongxia
Ma, Qingbian
Shen, Ning
author_sort Li, Shu
collection PubMed
description BACKGROUND: Computed tomography (CT) findings of COVID-19 patients were demonstrated by cases series and descriptive studies, but quantitative analysis performed by clinical doctors and studies on its predictive value were rarely seen. The aim of the study is to analyze CT score in COVID-19 patients and explore its predictive value. MATERIALS AND METHODS: We conducted a retrospective cohort study among confirmed COVID -19 patients with available CT images between February 8, 2020 and March 7, 2020. The lung was divided into six zones by the level of tracheal carina and the level of inferior pulmonary vein bilaterally on CT. Ground-glass opacity (GGO), consolidation, crazy-paving pattern and overall lung involvement were rated by Likert scale of 0–4 or binary as 0 or 1. Global severity score for each targeted pattern was calculated as total score of six zones. RESULTS: There were 53 patients and 137 CT scans included in the study. There were 18(34%) of the patients classified as moderate cases while 35(66%) patients were severe/critical cases. Severe/critical patients had higher CT scores in several types of abnormalities than moderate patients from the second week to the fourth week post symptom onset. Overall lung involvement score in the second week demonstrated predictive value for severity with a sensitivity of 81.0% and specificity of 69.2%. CONCLUSIONS: Our modified semi-quantitative CT scoring system for COVID-19 patients demonstrated feasibility. Overall lung involvement score on the second week had predictive value for clinical severity and could be indicator for further treatment.
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spelling pubmed-76959482020-12-01 Predictive value of chest CT scoring in COVID-19 patients in Wuhan, China: A retrospective cohort study Li, Shu Liu, Shaoyu Wang, Ben Li, Qiuyu Zhang, Hua Zeng, Lin Ge, Hongxia Ma, Qingbian Shen, Ning Respir Med Article BACKGROUND: Computed tomography (CT) findings of COVID-19 patients were demonstrated by cases series and descriptive studies, but quantitative analysis performed by clinical doctors and studies on its predictive value were rarely seen. The aim of the study is to analyze CT score in COVID-19 patients and explore its predictive value. MATERIALS AND METHODS: We conducted a retrospective cohort study among confirmed COVID -19 patients with available CT images between February 8, 2020 and March 7, 2020. The lung was divided into six zones by the level of tracheal carina and the level of inferior pulmonary vein bilaterally on CT. Ground-glass opacity (GGO), consolidation, crazy-paving pattern and overall lung involvement were rated by Likert scale of 0–4 or binary as 0 or 1. Global severity score for each targeted pattern was calculated as total score of six zones. RESULTS: There were 53 patients and 137 CT scans included in the study. There were 18(34%) of the patients classified as moderate cases while 35(66%) patients were severe/critical cases. Severe/critical patients had higher CT scores in several types of abnormalities than moderate patients from the second week to the fourth week post symptom onset. Overall lung involvement score in the second week demonstrated predictive value for severity with a sensitivity of 81.0% and specificity of 69.2%. CONCLUSIONS: Our modified semi-quantitative CT scoring system for COVID-19 patients demonstrated feasibility. Overall lung involvement score on the second week had predictive value for clinical severity and could be indicator for further treatment. The Authors. Published by Elsevier Ltd. 2021-01 2020-11-28 /pmc/articles/PMC7695948/ /pubmed/33296777 http://dx.doi.org/10.1016/j.rmed.2020.106271 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Li, Shu
Liu, Shaoyu
Wang, Ben
Li, Qiuyu
Zhang, Hua
Zeng, Lin
Ge, Hongxia
Ma, Qingbian
Shen, Ning
Predictive value of chest CT scoring in COVID-19 patients in Wuhan, China: A retrospective cohort study
title Predictive value of chest CT scoring in COVID-19 patients in Wuhan, China: A retrospective cohort study
title_full Predictive value of chest CT scoring in COVID-19 patients in Wuhan, China: A retrospective cohort study
title_fullStr Predictive value of chest CT scoring in COVID-19 patients in Wuhan, China: A retrospective cohort study
title_full_unstemmed Predictive value of chest CT scoring in COVID-19 patients in Wuhan, China: A retrospective cohort study
title_short Predictive value of chest CT scoring in COVID-19 patients in Wuhan, China: A retrospective cohort study
title_sort predictive value of chest ct scoring in covid-19 patients in wuhan, china: a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695948/
https://www.ncbi.nlm.nih.gov/pubmed/33296777
http://dx.doi.org/10.1016/j.rmed.2020.106271
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