Modification of a Constitutive to Glucose-Responsive Liver-Specific Promoter Resulted in Increased Efficacy of Adeno-Associated Virus Serotype 8-Insulin Gene Therapy of Diabetic Mice

We have previously used a hepatotropic adeno-associated viral (AAV) vector with a modified human insulin gene to treat diabetic mice. The HLP (hybrid liver-specific promoter) used was constitutively active and non-responsive to glucose. In this study, we examined the effects of addition of glucose r...

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Detalles Bibliográficos
Autores principales: Sia, Kian Chuan, Fu, Zhen Ying, Calne, Roy Y., Nathwani, Amit C., Lee, Kok Onn, Gan, Shu Uin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696068/
https://www.ncbi.nlm.nih.gov/pubmed/33202992
http://dx.doi.org/10.3390/cells9112474

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