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Troponin Elevation in Older Patients with Acute Pneumonia: Frequency and Prognostic Value
Cardiovascular (CV) events are particularly frequent after acute pneumonia (AP) in the elderly. We aimed to assess whether cardiac troponin I, a specific biomarker of myocardial injury, independently predicts CV events and death after AP in older inpatients. Among 214 consecutive patients with AP ag...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696095/ https://www.ncbi.nlm.nih.gov/pubmed/33182841 http://dx.doi.org/10.3390/jcm9113623 |
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author | Putot, Alain Bouhey, Emmanuel Tetu, Jennifer Barben, Jérémy Timsit, Eléonore Putot, Sophie Ray, Patrick Manckoundia, Patrick |
author_facet | Putot, Alain Bouhey, Emmanuel Tetu, Jennifer Barben, Jérémy Timsit, Eléonore Putot, Sophie Ray, Patrick Manckoundia, Patrick |
author_sort | Putot, Alain |
collection | PubMed |
description | Cardiovascular (CV) events are particularly frequent after acute pneumonia (AP) in the elderly. We aimed to assess whether cardiac troponin I, a specific biomarker of myocardial injury, independently predicts CV events and death after AP in older inpatients. Among 214 consecutive patients with AP aged ≥75 years admitted to a university hospital, 171 with a cardiac troponin I sample in the 72 h following diagnosis of AP were included, and 71 (42%) were found to have myocardial injury (troponin > 100 ng/L). Patients with and without myocardial injury were similar in terms of age, gender and comorbidities, but those with myocardial injury had more severe clinical presentation (median (interquartile range) Pneumonia Severity Index: 60 (40–95) vs. 45 (30–70), p = 0.003). Myocardial injury was strongly associated with in-hospital myocardial infarction (25% vs. 0%, p < 0.001), CV mortality (11 vs. 1%, p = 0.003) and all-cause mortality (34 vs. 13%, p = 0.002). After adjustment for confounders, myocardial injury remained a strong predictive factor of in-hospital mortality (odds ratio (95% confidence interval): 3.32 (1.42–7.73), p = 0.005) but not one-year mortality (1.61 (0.77–3.35), p = 0.2). Cardiac troponin I elevation, a specific biomarker of myocardial injury, was found in nearly half of an unselected cohort of older inpatients with AP and was associated with a threefold risk of in-hospital death. |
format | Online Article Text |
id | pubmed-7696095 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76960952020-11-29 Troponin Elevation in Older Patients with Acute Pneumonia: Frequency and Prognostic Value Putot, Alain Bouhey, Emmanuel Tetu, Jennifer Barben, Jérémy Timsit, Eléonore Putot, Sophie Ray, Patrick Manckoundia, Patrick J Clin Med Article Cardiovascular (CV) events are particularly frequent after acute pneumonia (AP) in the elderly. We aimed to assess whether cardiac troponin I, a specific biomarker of myocardial injury, independently predicts CV events and death after AP in older inpatients. Among 214 consecutive patients with AP aged ≥75 years admitted to a university hospital, 171 with a cardiac troponin I sample in the 72 h following diagnosis of AP were included, and 71 (42%) were found to have myocardial injury (troponin > 100 ng/L). Patients with and without myocardial injury were similar in terms of age, gender and comorbidities, but those with myocardial injury had more severe clinical presentation (median (interquartile range) Pneumonia Severity Index: 60 (40–95) vs. 45 (30–70), p = 0.003). Myocardial injury was strongly associated with in-hospital myocardial infarction (25% vs. 0%, p < 0.001), CV mortality (11 vs. 1%, p = 0.003) and all-cause mortality (34 vs. 13%, p = 0.002). After adjustment for confounders, myocardial injury remained a strong predictive factor of in-hospital mortality (odds ratio (95% confidence interval): 3.32 (1.42–7.73), p = 0.005) but not one-year mortality (1.61 (0.77–3.35), p = 0.2). Cardiac troponin I elevation, a specific biomarker of myocardial injury, was found in nearly half of an unselected cohort of older inpatients with AP and was associated with a threefold risk of in-hospital death. MDPI 2020-11-10 /pmc/articles/PMC7696095/ /pubmed/33182841 http://dx.doi.org/10.3390/jcm9113623 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Putot, Alain Bouhey, Emmanuel Tetu, Jennifer Barben, Jérémy Timsit, Eléonore Putot, Sophie Ray, Patrick Manckoundia, Patrick Troponin Elevation in Older Patients with Acute Pneumonia: Frequency and Prognostic Value |
title | Troponin Elevation in Older Patients with Acute Pneumonia: Frequency and Prognostic Value |
title_full | Troponin Elevation in Older Patients with Acute Pneumonia: Frequency and Prognostic Value |
title_fullStr | Troponin Elevation in Older Patients with Acute Pneumonia: Frequency and Prognostic Value |
title_full_unstemmed | Troponin Elevation in Older Patients with Acute Pneumonia: Frequency and Prognostic Value |
title_short | Troponin Elevation in Older Patients with Acute Pneumonia: Frequency and Prognostic Value |
title_sort | troponin elevation in older patients with acute pneumonia: frequency and prognostic value |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696095/ https://www.ncbi.nlm.nih.gov/pubmed/33182841 http://dx.doi.org/10.3390/jcm9113623 |
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