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Quality of Life in a Cohort of 1078 Women Diagnosed with Breast Cancer in Spain: 7-Year Follow-Up Results in the MCC-Spain Study

Breast cancer is the most frequent cause of tumors and net survival is increasing. Achieving a higher survival probability reinforces the importance of studying health-related quality of life (HR-QoL). The main aim of this work is to test the relationship between different sociodemographic, clinical...

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Autores principales: Alonso-Molero, Jéssica, Dierssen-Sotos, Trinidad, Gomez-Acebo, Ines, Fernandez de Larrea Baz, Nerea, Guevara, Marcela, Amiano, Pilar, Castaño-Vinyals, Gemma, Fernandez-Villa, Tania, Moreno, Victor, Bayo, Juan, Molina-Barceloa, Ana, Fernández-Ortíz, María, Suarez-Calleja, Claudia, Marcos-Gragera, Rafael, Castells, Xavier, Gil-Majuelo, Leire, Ardanaz, Eva, Pérez-Gómez, Beatriz, Kogevinas, Manolis, Pollán, Marina, Llorca, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696097/
https://www.ncbi.nlm.nih.gov/pubmed/33202919
http://dx.doi.org/10.3390/ijerph17228411
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author Alonso-Molero, Jéssica
Dierssen-Sotos, Trinidad
Gomez-Acebo, Ines
Fernandez de Larrea Baz, Nerea
Guevara, Marcela
Amiano, Pilar
Castaño-Vinyals, Gemma
Fernandez-Villa, Tania
Moreno, Victor
Bayo, Juan
Molina-Barceloa, Ana
Fernández-Ortíz, María
Suarez-Calleja, Claudia
Marcos-Gragera, Rafael
Castells, Xavier
Gil-Majuelo, Leire
Ardanaz, Eva
Pérez-Gómez, Beatriz
Kogevinas, Manolis
Pollán, Marina
Llorca, Javier
author_facet Alonso-Molero, Jéssica
Dierssen-Sotos, Trinidad
Gomez-Acebo, Ines
Fernandez de Larrea Baz, Nerea
Guevara, Marcela
Amiano, Pilar
Castaño-Vinyals, Gemma
Fernandez-Villa, Tania
Moreno, Victor
Bayo, Juan
Molina-Barceloa, Ana
Fernández-Ortíz, María
Suarez-Calleja, Claudia
Marcos-Gragera, Rafael
Castells, Xavier
Gil-Majuelo, Leire
Ardanaz, Eva
Pérez-Gómez, Beatriz
Kogevinas, Manolis
Pollán, Marina
Llorca, Javier
author_sort Alonso-Molero, Jéssica
collection PubMed
description Breast cancer is the most frequent cause of tumors and net survival is increasing. Achieving a higher survival probability reinforces the importance of studying health-related quality of life (HR-QoL). The main aim of this work is to test the relationship between different sociodemographic, clinical and tumor-intrinsic characteristics, and treatment received with HR-QoL measured using SF-12 and the FACT/NCCN (National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy) Breast Symptom Index (FBSI). Women with breast cancer recruited between 2008 and 2013 and followed-up until 2017–2018 in a prospective cohort answered two HR-QoL surveys: the SF-12 and FBSI. The scores obtained were related to woman and tumor characteristics using linear regression models. The telephone survey was answered by 1078 women out of 1685 with medical record follow-up (64%). Increases in all three HR-QoL scores were associated with higher educational level. The score differences between women with university qualifications and women with no schooling were 5.43 for PCS-12, 6.13 for MCS-12 and 4.29 for FBSI. Histological grade at diagnosis and recurrence in the follow-up displayed a significant association with mental and physical HR-QoL, respectively. First-line treatment received was not associated with HR-QoL scores. On the other hand, most tumor characteristics were not associated with HR-QoL. As breast cancer survival is improving, further studies are needed to ascertain if these differences still hold in the long run.
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spelling pubmed-76960972020-11-29 Quality of Life in a Cohort of 1078 Women Diagnosed with Breast Cancer in Spain: 7-Year Follow-Up Results in the MCC-Spain Study Alonso-Molero, Jéssica Dierssen-Sotos, Trinidad Gomez-Acebo, Ines Fernandez de Larrea Baz, Nerea Guevara, Marcela Amiano, Pilar Castaño-Vinyals, Gemma Fernandez-Villa, Tania Moreno, Victor Bayo, Juan Molina-Barceloa, Ana Fernández-Ortíz, María Suarez-Calleja, Claudia Marcos-Gragera, Rafael Castells, Xavier Gil-Majuelo, Leire Ardanaz, Eva Pérez-Gómez, Beatriz Kogevinas, Manolis Pollán, Marina Llorca, Javier Int J Environ Res Public Health Article Breast cancer is the most frequent cause of tumors and net survival is increasing. Achieving a higher survival probability reinforces the importance of studying health-related quality of life (HR-QoL). The main aim of this work is to test the relationship between different sociodemographic, clinical and tumor-intrinsic characteristics, and treatment received with HR-QoL measured using SF-12 and the FACT/NCCN (National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy) Breast Symptom Index (FBSI). Women with breast cancer recruited between 2008 and 2013 and followed-up until 2017–2018 in a prospective cohort answered two HR-QoL surveys: the SF-12 and FBSI. The scores obtained were related to woman and tumor characteristics using linear regression models. The telephone survey was answered by 1078 women out of 1685 with medical record follow-up (64%). Increases in all three HR-QoL scores were associated with higher educational level. The score differences between women with university qualifications and women with no schooling were 5.43 for PCS-12, 6.13 for MCS-12 and 4.29 for FBSI. Histological grade at diagnosis and recurrence in the follow-up displayed a significant association with mental and physical HR-QoL, respectively. First-line treatment received was not associated with HR-QoL scores. On the other hand, most tumor characteristics were not associated with HR-QoL. As breast cancer survival is improving, further studies are needed to ascertain if these differences still hold in the long run. MDPI 2020-11-13 2020-11 /pmc/articles/PMC7696097/ /pubmed/33202919 http://dx.doi.org/10.3390/ijerph17228411 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alonso-Molero, Jéssica
Dierssen-Sotos, Trinidad
Gomez-Acebo, Ines
Fernandez de Larrea Baz, Nerea
Guevara, Marcela
Amiano, Pilar
Castaño-Vinyals, Gemma
Fernandez-Villa, Tania
Moreno, Victor
Bayo, Juan
Molina-Barceloa, Ana
Fernández-Ortíz, María
Suarez-Calleja, Claudia
Marcos-Gragera, Rafael
Castells, Xavier
Gil-Majuelo, Leire
Ardanaz, Eva
Pérez-Gómez, Beatriz
Kogevinas, Manolis
Pollán, Marina
Llorca, Javier
Quality of Life in a Cohort of 1078 Women Diagnosed with Breast Cancer in Spain: 7-Year Follow-Up Results in the MCC-Spain Study
title Quality of Life in a Cohort of 1078 Women Diagnosed with Breast Cancer in Spain: 7-Year Follow-Up Results in the MCC-Spain Study
title_full Quality of Life in a Cohort of 1078 Women Diagnosed with Breast Cancer in Spain: 7-Year Follow-Up Results in the MCC-Spain Study
title_fullStr Quality of Life in a Cohort of 1078 Women Diagnosed with Breast Cancer in Spain: 7-Year Follow-Up Results in the MCC-Spain Study
title_full_unstemmed Quality of Life in a Cohort of 1078 Women Diagnosed with Breast Cancer in Spain: 7-Year Follow-Up Results in the MCC-Spain Study
title_short Quality of Life in a Cohort of 1078 Women Diagnosed with Breast Cancer in Spain: 7-Year Follow-Up Results in the MCC-Spain Study
title_sort quality of life in a cohort of 1078 women diagnosed with breast cancer in spain: 7-year follow-up results in the mcc-spain study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696097/
https://www.ncbi.nlm.nih.gov/pubmed/33202919
http://dx.doi.org/10.3390/ijerph17228411
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