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Phage Prevalence in the Human Urinary Tract—Current Knowledge and Therapeutic Implications
Recent metagenomic analyses imply an immense abundance of phages in the human body. Samples collected from different sites (lungs, skin, oral cavity, intestines, ascitic fluid, and urine) reveal a generally greater number of phage particles than that of eukaryotic viruses. The presence of phages in...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696197/ https://www.ncbi.nlm.nih.gov/pubmed/33212807 http://dx.doi.org/10.3390/microorganisms8111802 |
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author | Żaczek, Maciej Weber-Dąbrowska, Beata Międzybrodzki, Ryszard Górski, Andrzej |
author_facet | Żaczek, Maciej Weber-Dąbrowska, Beata Międzybrodzki, Ryszard Górski, Andrzej |
author_sort | Żaczek, Maciej |
collection | PubMed |
description | Recent metagenomic analyses imply an immense abundance of phages in the human body. Samples collected from different sites (lungs, skin, oral cavity, intestines, ascitic fluid, and urine) reveal a generally greater number of phage particles than that of eukaryotic viruses. The presence of phages in those tissues and fluids reflects the paths they must overcome in the human body, but may also relate to the health statuses of individuals. Besides shaping bacterial metabolism and community structure, the role of phages circulating in body fluids has not been fully understood yet. The lack of relevant reports is especially visible with regard to the human urobiome. Certainly, phage presence and the role they have to fulfill in the human urinary tract raises questions on potential therapeutic connotations. Urinary tract infections (UTIs) are among the most common bacterial infections in humans and their treatment poses a difficult therapeutic dilemma. Despite effective antibiotic therapy, these infections tend to recur. In this review, we summarized the recent data on phage presence in the human urinary tract and its possible implications for health and disease. |
format | Online Article Text |
id | pubmed-7696197 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76961972020-11-29 Phage Prevalence in the Human Urinary Tract—Current Knowledge and Therapeutic Implications Żaczek, Maciej Weber-Dąbrowska, Beata Międzybrodzki, Ryszard Górski, Andrzej Microorganisms Review Recent metagenomic analyses imply an immense abundance of phages in the human body. Samples collected from different sites (lungs, skin, oral cavity, intestines, ascitic fluid, and urine) reveal a generally greater number of phage particles than that of eukaryotic viruses. The presence of phages in those tissues and fluids reflects the paths they must overcome in the human body, but may also relate to the health statuses of individuals. Besides shaping bacterial metabolism and community structure, the role of phages circulating in body fluids has not been fully understood yet. The lack of relevant reports is especially visible with regard to the human urobiome. Certainly, phage presence and the role they have to fulfill in the human urinary tract raises questions on potential therapeutic connotations. Urinary tract infections (UTIs) are among the most common bacterial infections in humans and their treatment poses a difficult therapeutic dilemma. Despite effective antibiotic therapy, these infections tend to recur. In this review, we summarized the recent data on phage presence in the human urinary tract and its possible implications for health and disease. MDPI 2020-11-17 /pmc/articles/PMC7696197/ /pubmed/33212807 http://dx.doi.org/10.3390/microorganisms8111802 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Żaczek, Maciej Weber-Dąbrowska, Beata Międzybrodzki, Ryszard Górski, Andrzej Phage Prevalence in the Human Urinary Tract—Current Knowledge and Therapeutic Implications |
title | Phage Prevalence in the Human Urinary Tract—Current Knowledge and Therapeutic Implications |
title_full | Phage Prevalence in the Human Urinary Tract—Current Knowledge and Therapeutic Implications |
title_fullStr | Phage Prevalence in the Human Urinary Tract—Current Knowledge and Therapeutic Implications |
title_full_unstemmed | Phage Prevalence in the Human Urinary Tract—Current Knowledge and Therapeutic Implications |
title_short | Phage Prevalence in the Human Urinary Tract—Current Knowledge and Therapeutic Implications |
title_sort | phage prevalence in the human urinary tract—current knowledge and therapeutic implications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696197/ https://www.ncbi.nlm.nih.gov/pubmed/33212807 http://dx.doi.org/10.3390/microorganisms8111802 |
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