Cargando…

Assessing the Thiamine Diphosphate Dependent Pyruvate Dehydrogenase E1 Subunit for Carboligation Reactions with Aliphatic Ketoacids

The synthetic properties of the Thiamine diphosphate (ThDP)-dependent pyruvate dehydrogenase E1 subunit from Escherichia coli (EcPDH E1) was assessed for carboligation reactions with aliphatic ketoacids. Due to its role in metabolism, EcPDH E1 was previously characterised with respect to its biochem...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marsden, Stefan R., McMillan, Duncan G. G., Hanefeld, Ulf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696235/ https://www.ncbi.nlm.nih.gov/pubmed/33207817 http://dx.doi.org/10.3390/ijms21228641

Ejemplares similares

In Situ Acetaldehyde Synthesis for Carboligation Reactions
por: Biewenga, Lieuwe, et al.
Publicado: (2020)

Potent Radical-Scavenging Activities of Thiamin and Thiamin Diphosphate
por: Okai, Yasuji, et al.
Publicado: (2007)

Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity
por: Chan, Alex H. Y., et al.
Publicado: (2022)

Correction: Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity
por: Chan, Alex H. Y., et al.
Publicado: (2022)

The genes and enzymes involved in the biosynthesis of thiamin and thiamin diphosphate in yeasts
por: Kowalska, Ewa, et al.
Publicado: (2008)

Influence of Organic Solvents on Enzymatic Asymmetric Carboligations
por: Gerhards, Tina, et al.
Publicado: (2012)

Inhibition of Thiamine Diphosphate-Dependent Enzymes by Triazole-Based Thiamine Analogues
por: Chan, Alex H. Y., et al.
Publicado: (2023)

Thiamine Diphosphate in Whole Blood, Thiamine and Thiamine Monophosphate in Breast-Milk in a Refugee Population
por: Stuetz, Wolfgang, et al.
Publicado: (2012)

Comparable Performance Characteristics of Plasma Thiamine and Erythrocyte Thiamine Diphosphate in Response to Thiamine Fortification in Rural Cambodian Women
por: McCann, Adrian, et al.
Publicado: (2017)

Thiamine Responsive Pyruvate Dehydrogenase Complex Deficiency: A Potentially Treatable Cause of Leigh's Disease
por: Jauhari, Prashant, et al.
Publicado: (2017)

A standard numbering scheme for thiamine diphosphate-dependent decarboxylases
por: Vogel, Constantin, et al.
Publicado: (2012)

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
por: Zhang, Shuai, et al.
Publicado: (2014)

Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases
por: Seim, Gretchen L., et al.
Publicado: (2022)

Thiamine diphosphate adenylyl transferase from E. coli: functional characterization of the enzyme synthesizing adenosine thiamine triphosphate
por: Makarchikov, Alexander F, et al.
Publicado: (2007)

The coenzyme thiamine diphosphate displays a daily rhythm in the Arabidopsis nucleus
por: Noordally, Zeenat B., et al.
Publicado: (2020)

Loss of the Drosophila branched-chain α-ketoacid dehydrogenase complex results in neuronal dysfunction
por: Tsai, Hui-Ying, et al.
Publicado: (2020)

Rearrangement of mitochondrial pyruvate dehydrogenase subunit dihydrolipoamide dehydrogenase protein–protein interactions by the MDM2 ligand nutlin‐3
por: Way, Luke, et al.
Publicado: (2016)

A novel null mutation in the pyruvate dehydrogenase phosphatase catalytic subunit gene (PDP1) causing pyruvate dehydrogenase complex deficiency
por: Bedoyan, Jirair K., et al.
Publicado: (2019)

Snapshots of Catalysis in the E1 Subunit of the Pyruvate Dehydrogenase Multienzyme Complex
por: Pei, Xue Yuan, et al.
Publicado: (2008)

Mitochondria from cultured cells derived from normal and thiamine-responsive megaloblastic anemia individuals efficiently import thiamine diphosphate
por: Song, Qilin, et al.
Publicado: (2002)

Comparison of Thiamin Diphosphate High-Performance Liquid Chromatography and Erythrocyte Transketolase Assays for Evaluating Thiamin Status in Malaria Patients without Beriberi
por: Taylor, Andrew J., et al.
Publicado: (2020)

The Trypanosoma brucei-Derived Ketoacids, Indole Pyruvate and Hydroxyphenylpyruvate, Induce HO-1 Expression and Suppress Inflammatory Responses in Human Dendritic Cells
por: Fitzgerald, Hannah K., et al.
Publicado: (2022)

Characterization of Mycoplasma gallisepticum pyruvate dehydrogenase alpha and beta subunits and their roles in cytoadherence
por: Qi, Jingjing, et al.
Publicado: (2018)

Hexokinase II promotes the Warburg effect by phosphorylating alpha subunit of pyruvate dehydrogenase
por: Luo, Fangxiu, et al.
Publicado: (2019)

How phosphorylation influences E1 subunit pyruvate dehydrogenase: A computational study
por: Sgrignani, Jacopo, et al.
Publicado: (2018)

Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels
por: Roth Flach, Rachel J., et al.
Publicado: (2023)

Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenase complex and impact muscle cell metabolism
por: Arp, Nicholas L., et al.
Publicado: (2023)

Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenase complex and impact muscle cell metabolism
por: Arp, Nicholas L., et al.
Publicado: (2023)

Inhibiting Sperm Pyruvate Dehydrogenase Complex and Its E3 Subunit, Dihydrolipoamide Dehydrogenase Affects Fertilization in Syrian Hamsters
por: Siva, Archana B., et al.
Publicado: (2014)

The Thiamine diphosphate dependent Enzyme Engineering Database: A tool for the systematic analysis of sequence and structure relations
por: Widmann, Michael, et al.
Publicado: (2010)

Specific inhibition by synthetic analogs of pyruvate reveals that the pyruvate dehydrogenase reaction is essential for metabolism and viability of glioblastoma cells
por: Bunik, Victoria I., et al.
Publicado: (2015)

Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
por: Park, Sungmi, et al.
Publicado: (2018)

Data on the proliferation and differentiation of C2C12 myoblast treated with branched-chain ketoacid dehydrogenase kinase inhibitor
por: Sato, Yoriko, et al.
Publicado: (2020)

Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors
por: Liu, Shenping, et al.
Publicado: (2023)

Michael hydratase alcohol dehydrogenase or just alcohol dehydrogenase?
por: Resch, Verena, et al.
Publicado: (2014)

Stereoselective Synthesis of Functionalized Bicyclic Scaffolds by Passerini 3‐Center‐2‐Component Reactions of Cyclic Ketoacids
por: Cioc, Răzvan C., et al.
Publicado: (2017)

Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer’s disease, whereas amyloid deposition does not
por: Sang, Shaoming, et al.
Publicado: (2018)

Computational characterization of enzyme-bound thiamin diphosphate reveals a surprisingly stable tricyclic state: implications for catalysis
por: Planas, Ferran, et al.
Publicado: (2019)

Role of pyruvate dehydrogenase complex in traumatic brain injury and Measurement of pyruvate dehydrogenase enzyme by dipstick test
por: Sharma, Pushpa, et al.
Publicado: (2009)

Carboligation of 5-(hydroxymethyl)furfural via whole-cell catalysis to form C12 furan derivatives and their use for hydrazone formation
por: Glaser, Sara Jonsdottir, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_l1l4qcqa9bu6bohavq930c1j8v