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Review: Ischemia Reperfusion Injury—A Translational Perspective in Organ Transplantation

Thanks to the development of new, more potent and selective immunosuppressive drugs together with advances in surgical techniques, organ transplantation has emerged from an experimental surgery over fifty years ago to being the treatment of choice for many end-stage organ diseases, with over 139,000...

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Autores principales: Fernández, André Renaldo, Sánchez-Tarjuelo, Rodrigo, Cravedi, Paolo, Ochando, Jordi, López-Hoyos, Marcos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696417/
https://www.ncbi.nlm.nih.gov/pubmed/33202744
http://dx.doi.org/10.3390/ijms21228549
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author Fernández, André Renaldo
Sánchez-Tarjuelo, Rodrigo
Cravedi, Paolo
Ochando, Jordi
López-Hoyos, Marcos
author_facet Fernández, André Renaldo
Sánchez-Tarjuelo, Rodrigo
Cravedi, Paolo
Ochando, Jordi
López-Hoyos, Marcos
author_sort Fernández, André Renaldo
collection PubMed
description Thanks to the development of new, more potent and selective immunosuppressive drugs together with advances in surgical techniques, organ transplantation has emerged from an experimental surgery over fifty years ago to being the treatment of choice for many end-stage organ diseases, with over 139,000 organ transplants performed worldwide in 2019. Inherent to the transplantation procedure is the fact that the donor organ is subjected to blood flow cessation and ischemia during harvesting, which is followed by preservation and reperfusion of the organ once transplanted into the recipient. Consequently, ischemia/reperfusion induces a significant injury to the graft with activation of the immune response in the recipient and deleterious effect on the graft. The purpose of this review is to discuss and shed new light on the pathways involved in ischemia/reperfusion injury (IRI) that act at different stages during the donation process, surgery, and immediate post-transplant period. Here, we present strategies that combine various treatments targeted at different mechanistic pathways during several time points to prevent graft loss secondary to the inflammation caused by IRI.
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spelling pubmed-76964172020-11-29 Review: Ischemia Reperfusion Injury—A Translational Perspective in Organ Transplantation Fernández, André Renaldo Sánchez-Tarjuelo, Rodrigo Cravedi, Paolo Ochando, Jordi López-Hoyos, Marcos Int J Mol Sci Review Thanks to the development of new, more potent and selective immunosuppressive drugs together with advances in surgical techniques, organ transplantation has emerged from an experimental surgery over fifty years ago to being the treatment of choice for many end-stage organ diseases, with over 139,000 organ transplants performed worldwide in 2019. Inherent to the transplantation procedure is the fact that the donor organ is subjected to blood flow cessation and ischemia during harvesting, which is followed by preservation and reperfusion of the organ once transplanted into the recipient. Consequently, ischemia/reperfusion induces a significant injury to the graft with activation of the immune response in the recipient and deleterious effect on the graft. The purpose of this review is to discuss and shed new light on the pathways involved in ischemia/reperfusion injury (IRI) that act at different stages during the donation process, surgery, and immediate post-transplant period. Here, we present strategies that combine various treatments targeted at different mechanistic pathways during several time points to prevent graft loss secondary to the inflammation caused by IRI. MDPI 2020-11-13 /pmc/articles/PMC7696417/ /pubmed/33202744 http://dx.doi.org/10.3390/ijms21228549 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fernández, André Renaldo
Sánchez-Tarjuelo, Rodrigo
Cravedi, Paolo
Ochando, Jordi
López-Hoyos, Marcos
Review: Ischemia Reperfusion Injury—A Translational Perspective in Organ Transplantation
title Review: Ischemia Reperfusion Injury—A Translational Perspective in Organ Transplantation
title_full Review: Ischemia Reperfusion Injury—A Translational Perspective in Organ Transplantation
title_fullStr Review: Ischemia Reperfusion Injury—A Translational Perspective in Organ Transplantation
title_full_unstemmed Review: Ischemia Reperfusion Injury—A Translational Perspective in Organ Transplantation
title_short Review: Ischemia Reperfusion Injury—A Translational Perspective in Organ Transplantation
title_sort review: ischemia reperfusion injury—a translational perspective in organ transplantation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696417/
https://www.ncbi.nlm.nih.gov/pubmed/33202744
http://dx.doi.org/10.3390/ijms21228549
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