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Metabolic Syndrome and Abnormal Peri-Organ or Intra-Organ Fat (APIFat) Deposition in Chronic Obstructive Pulmonary Disease: An Overview

Chronic obstructive pulmonary disease (COPD) is a common disorder with an increasing prevalence, characterised by persistent respiratory symptoms and airflow limitation. Systemic inflammation is involved in the pathogenesis of COPD and can also predispose to metabolic disorders (e.g., metabolic synd...

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Autores principales: Katsiki, Niki, Stoian, Anca Pantea, Steiropoulos, Paschalis, Papanas, Nikolaos, Suceveanu, Andra-Iulia, Mikhailidis, Dimitri P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696438/
https://www.ncbi.nlm.nih.gov/pubmed/33203192
http://dx.doi.org/10.3390/metabo10110465
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author Katsiki, Niki
Stoian, Anca Pantea
Steiropoulos, Paschalis
Papanas, Nikolaos
Suceveanu, Andra-Iulia
Mikhailidis, Dimitri P.
author_facet Katsiki, Niki
Stoian, Anca Pantea
Steiropoulos, Paschalis
Papanas, Nikolaos
Suceveanu, Andra-Iulia
Mikhailidis, Dimitri P.
author_sort Katsiki, Niki
collection PubMed
description Chronic obstructive pulmonary disease (COPD) is a common disorder with an increasing prevalence, characterised by persistent respiratory symptoms and airflow limitation. Systemic inflammation is involved in the pathogenesis of COPD and can also predispose to metabolic disorders (e.g., metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD)). Such comorbidities can negatively affect COPD outcomes, cardiovascular risk, and quality of life. Apart from NAFLD, abnormal peri-organ or intra-organ fat (APIFat) could be considered as markers for cardiometabolic diseases and even for COPD. The present narrative review considers the associations of COPD with MetS, NAFLD, and other APIFat, including epicardial, perirenal, peripancreatic, and intramuscular adipose tissue. Further research is needed to define these relationships and identify any potential clinical implications.
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spelling pubmed-76964382020-11-29 Metabolic Syndrome and Abnormal Peri-Organ or Intra-Organ Fat (APIFat) Deposition in Chronic Obstructive Pulmonary Disease: An Overview Katsiki, Niki Stoian, Anca Pantea Steiropoulos, Paschalis Papanas, Nikolaos Suceveanu, Andra-Iulia Mikhailidis, Dimitri P. Metabolites Review Chronic obstructive pulmonary disease (COPD) is a common disorder with an increasing prevalence, characterised by persistent respiratory symptoms and airflow limitation. Systemic inflammation is involved in the pathogenesis of COPD and can also predispose to metabolic disorders (e.g., metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD)). Such comorbidities can negatively affect COPD outcomes, cardiovascular risk, and quality of life. Apart from NAFLD, abnormal peri-organ or intra-organ fat (APIFat) could be considered as markers for cardiometabolic diseases and even for COPD. The present narrative review considers the associations of COPD with MetS, NAFLD, and other APIFat, including epicardial, perirenal, peripancreatic, and intramuscular adipose tissue. Further research is needed to define these relationships and identify any potential clinical implications. MDPI 2020-11-15 /pmc/articles/PMC7696438/ /pubmed/33203192 http://dx.doi.org/10.3390/metabo10110465 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Katsiki, Niki
Stoian, Anca Pantea
Steiropoulos, Paschalis
Papanas, Nikolaos
Suceveanu, Andra-Iulia
Mikhailidis, Dimitri P.
Metabolic Syndrome and Abnormal Peri-Organ or Intra-Organ Fat (APIFat) Deposition in Chronic Obstructive Pulmonary Disease: An Overview
title Metabolic Syndrome and Abnormal Peri-Organ or Intra-Organ Fat (APIFat) Deposition in Chronic Obstructive Pulmonary Disease: An Overview
title_full Metabolic Syndrome and Abnormal Peri-Organ or Intra-Organ Fat (APIFat) Deposition in Chronic Obstructive Pulmonary Disease: An Overview
title_fullStr Metabolic Syndrome and Abnormal Peri-Organ or Intra-Organ Fat (APIFat) Deposition in Chronic Obstructive Pulmonary Disease: An Overview
title_full_unstemmed Metabolic Syndrome and Abnormal Peri-Organ or Intra-Organ Fat (APIFat) Deposition in Chronic Obstructive Pulmonary Disease: An Overview
title_short Metabolic Syndrome and Abnormal Peri-Organ or Intra-Organ Fat (APIFat) Deposition in Chronic Obstructive Pulmonary Disease: An Overview
title_sort metabolic syndrome and abnormal peri-organ or intra-organ fat (apifat) deposition in chronic obstructive pulmonary disease: an overview
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696438/
https://www.ncbi.nlm.nih.gov/pubmed/33203192
http://dx.doi.org/10.3390/metabo10110465
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