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An Accurate and Robust Method for Spike Sorting Based on Convolutional Neural Networks

In the fields of neuroscience and biomedical signal processing, spike sorting is a crucial step to extract the information of single neurons from extracellular recordings. In this paper, we propose a novel deep learning approach based on one-dimensional convolutional neural networks (1D-CNNs) to imp...

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Detalles Bibliográficos
Autores principales: Li, Zhaohui, Wang, Yongtian, Zhang, Nan, Li, Xiaoli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696441/
https://www.ncbi.nlm.nih.gov/pubmed/33187098
http://dx.doi.org/10.3390/brainsci10110835
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author Li, Zhaohui
Wang, Yongtian
Zhang, Nan
Li, Xiaoli
author_facet Li, Zhaohui
Wang, Yongtian
Zhang, Nan
Li, Xiaoli
author_sort Li, Zhaohui
collection PubMed
description In the fields of neuroscience and biomedical signal processing, spike sorting is a crucial step to extract the information of single neurons from extracellular recordings. In this paper, we propose a novel deep learning approach based on one-dimensional convolutional neural networks (1D-CNNs) to implement accurate and robust spike sorting. The results of the simulated data demonstrated that the clustering accuracy in most datasets was greater than 99%, despite the multiple levels of noise and various degrees of overlapped spikes. Moreover, the proposed method performed significantly better than the state-of-the-art method named “WMsorting” and a deep-learning-based multilayer perceptron (MLP) model. In addition, the experimental data recorded from the primary visual cortex of a macaque monkey were used to evaluate the proposed method in a practical application. It was shown that the method could successfully isolate most spikes of different neurons (ranging from two to five) by training the 1D-CNN model with a small number of manually labeled spikes. Considering the above, the deep learning method proposed in this paper is of great advantage for spike sorting with high accuracy and strong robustness. It lays the foundation for application in more challenging works, such as distinguishing overlapped spikes and the simultaneous sorting of multichannel recordings.
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spelling pubmed-76964412020-11-29 An Accurate and Robust Method for Spike Sorting Based on Convolutional Neural Networks Li, Zhaohui Wang, Yongtian Zhang, Nan Li, Xiaoli Brain Sci Article In the fields of neuroscience and biomedical signal processing, spike sorting is a crucial step to extract the information of single neurons from extracellular recordings. In this paper, we propose a novel deep learning approach based on one-dimensional convolutional neural networks (1D-CNNs) to implement accurate and robust spike sorting. The results of the simulated data demonstrated that the clustering accuracy in most datasets was greater than 99%, despite the multiple levels of noise and various degrees of overlapped spikes. Moreover, the proposed method performed significantly better than the state-of-the-art method named “WMsorting” and a deep-learning-based multilayer perceptron (MLP) model. In addition, the experimental data recorded from the primary visual cortex of a macaque monkey were used to evaluate the proposed method in a practical application. It was shown that the method could successfully isolate most spikes of different neurons (ranging from two to five) by training the 1D-CNN model with a small number of manually labeled spikes. Considering the above, the deep learning method proposed in this paper is of great advantage for spike sorting with high accuracy and strong robustness. It lays the foundation for application in more challenging works, such as distinguishing overlapped spikes and the simultaneous sorting of multichannel recordings. MDPI 2020-11-11 /pmc/articles/PMC7696441/ /pubmed/33187098 http://dx.doi.org/10.3390/brainsci10110835 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Zhaohui
Wang, Yongtian
Zhang, Nan
Li, Xiaoli
An Accurate and Robust Method for Spike Sorting Based on Convolutional Neural Networks
title An Accurate and Robust Method for Spike Sorting Based on Convolutional Neural Networks
title_full An Accurate and Robust Method for Spike Sorting Based on Convolutional Neural Networks
title_fullStr An Accurate and Robust Method for Spike Sorting Based on Convolutional Neural Networks
title_full_unstemmed An Accurate and Robust Method for Spike Sorting Based on Convolutional Neural Networks
title_short An Accurate and Robust Method for Spike Sorting Based on Convolutional Neural Networks
title_sort accurate and robust method for spike sorting based on convolutional neural networks
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696441/
https://www.ncbi.nlm.nih.gov/pubmed/33187098
http://dx.doi.org/10.3390/brainsci10110835
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