A Novel HGF/SF Receptor (MET) Agonist Transiently Delays the Disease Progression in an Amyotrophic Lateral Sclerosis Mouse Model by Promoting Neuronal Survival and Dampening the Immune Dysregulation

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease with no effective treatment. The Hepatocyte Growth Factor/Scatter Factor (HGF/SF), through its receptor MET, is one of the most potent survival-promoting factors for motor neurons (MN) and is known as a modulator of immune cell...

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Detalles Bibliográficos
Autores principales: Vallarola, Antonio, Tortarolo, Massimo, De Gioia, Roberta, Iamele, Luisa, de Jonge, Hugo, de Nola, Giovanni, Bovio, Enrica, Pasetto, Laura, Bonetto, Valentina, Freschi, Mattia, Bendotti, Caterina, Gherardi, Ermanno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696450/
https://www.ncbi.nlm.nih.gov/pubmed/33198383
http://dx.doi.org/10.3390/ijms21228542

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