Cargando…

Novel Biocompatible Zr-Based Alloy with Low Young’s Modulus and Magnetic Susceptibility for Biomedical Implants

The microstructure, mechanical properties, magnetic susceptibility, electrochemical corrosion performance, in vitro cell compatibility and blood consistency of Zr-16Nb-xTi (x = 0, 4, 8, 12 and 16 wt.%) materials were investigated as potential materials for biomedical implants. X-ray diffraction (XRD...

Descripción completa

Detalles Bibliográficos
Autores principales: Xue, Renhao, Wang, Dong, Yang, Dawei, Zhang, Ligang, Xu, Xiaoning, Liu, Libin, Wu, Di
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696516/
https://www.ncbi.nlm.nih.gov/pubmed/33202987
http://dx.doi.org/10.3390/ma13225130
_version_ 1783615422537400320
author Xue, Renhao
Wang, Dong
Yang, Dawei
Zhang, Ligang
Xu, Xiaoning
Liu, Libin
Wu, Di
author_facet Xue, Renhao
Wang, Dong
Yang, Dawei
Zhang, Ligang
Xu, Xiaoning
Liu, Libin
Wu, Di
author_sort Xue, Renhao
collection PubMed
description The microstructure, mechanical properties, magnetic susceptibility, electrochemical corrosion performance, in vitro cell compatibility and blood consistency of Zr-16Nb-xTi (x = 0, 4, 8, 12 and 16 wt.%) materials were investigated as potential materials for biomedical implants. X-ray diffraction (XRD) and Transmission electron microscopy (TEM) analyses revealed the secondary phase martensite α’ formed during the quenching process. The phase composition contained metastable β and martensite α’, resulting from Ti addition. These phase constitutions were the main causes of a low Young’s modulus and magnetic susceptibility. The in vitro cytocompatibility analysis illustrated that the MG63 cells maintained high activity (from 91% to 97%) after culturing in Zr-16Nb-xTi extraction media for 12 days due to the high internal biocompatibility of Zr, Nb and Ti elements, as well as the optimal corrosion resistance of Zr-16Nb-xTi. On the basis of Inductively coupled plasma optical emission spectrometry (ICP-OES) ion release studies, the concentration of Zr, Nb and Ti was noted to reach the equipment detective limit of 0.001 mg/L, which was much lower than pure Ti. With respect to the corrosion behavior in Hank’s solution, Zr-16Nb-16Ti displayed superior properties, possessing the lowest corrosion current density and widest passivation region, attributed to the addition of Ti. The blood compatibility test illustrated that the Zr-16Nb-xTi materials were nonhemolytic, and the platelets maintained a spherical shape, with no aggregation or activation on Zr-16Nb-xTi. Overall, Ti addition has obvious effects on the developed Zr-16Nb-xTi alloys, and Zr-16Nb-4Ti exhibited low magnetic susceptibility, low modulus, good biocompatibility and proper corrosion properties, demonstrating the potential of use as implant biomaterials.
format Online
Article
Text
id pubmed-7696516
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-76965162020-11-29 Novel Biocompatible Zr-Based Alloy with Low Young’s Modulus and Magnetic Susceptibility for Biomedical Implants Xue, Renhao Wang, Dong Yang, Dawei Zhang, Ligang Xu, Xiaoning Liu, Libin Wu, Di Materials (Basel) Article The microstructure, mechanical properties, magnetic susceptibility, electrochemical corrosion performance, in vitro cell compatibility and blood consistency of Zr-16Nb-xTi (x = 0, 4, 8, 12 and 16 wt.%) materials were investigated as potential materials for biomedical implants. X-ray diffraction (XRD) and Transmission electron microscopy (TEM) analyses revealed the secondary phase martensite α’ formed during the quenching process. The phase composition contained metastable β and martensite α’, resulting from Ti addition. These phase constitutions were the main causes of a low Young’s modulus and magnetic susceptibility. The in vitro cytocompatibility analysis illustrated that the MG63 cells maintained high activity (from 91% to 97%) after culturing in Zr-16Nb-xTi extraction media for 12 days due to the high internal biocompatibility of Zr, Nb and Ti elements, as well as the optimal corrosion resistance of Zr-16Nb-xTi. On the basis of Inductively coupled plasma optical emission spectrometry (ICP-OES) ion release studies, the concentration of Zr, Nb and Ti was noted to reach the equipment detective limit of 0.001 mg/L, which was much lower than pure Ti. With respect to the corrosion behavior in Hank’s solution, Zr-16Nb-16Ti displayed superior properties, possessing the lowest corrosion current density and widest passivation region, attributed to the addition of Ti. The blood compatibility test illustrated that the Zr-16Nb-xTi materials were nonhemolytic, and the platelets maintained a spherical shape, with no aggregation or activation on Zr-16Nb-xTi. Overall, Ti addition has obvious effects on the developed Zr-16Nb-xTi alloys, and Zr-16Nb-4Ti exhibited low magnetic susceptibility, low modulus, good biocompatibility and proper corrosion properties, demonstrating the potential of use as implant biomaterials. MDPI 2020-11-13 /pmc/articles/PMC7696516/ /pubmed/33202987 http://dx.doi.org/10.3390/ma13225130 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xue, Renhao
Wang, Dong
Yang, Dawei
Zhang, Ligang
Xu, Xiaoning
Liu, Libin
Wu, Di
Novel Biocompatible Zr-Based Alloy with Low Young’s Modulus and Magnetic Susceptibility for Biomedical Implants
title Novel Biocompatible Zr-Based Alloy with Low Young’s Modulus and Magnetic Susceptibility for Biomedical Implants
title_full Novel Biocompatible Zr-Based Alloy with Low Young’s Modulus and Magnetic Susceptibility for Biomedical Implants
title_fullStr Novel Biocompatible Zr-Based Alloy with Low Young’s Modulus and Magnetic Susceptibility for Biomedical Implants
title_full_unstemmed Novel Biocompatible Zr-Based Alloy with Low Young’s Modulus and Magnetic Susceptibility for Biomedical Implants
title_short Novel Biocompatible Zr-Based Alloy with Low Young’s Modulus and Magnetic Susceptibility for Biomedical Implants
title_sort novel biocompatible zr-based alloy with low young’s modulus and magnetic susceptibility for biomedical implants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696516/
https://www.ncbi.nlm.nih.gov/pubmed/33202987
http://dx.doi.org/10.3390/ma13225130
work_keys_str_mv AT xuerenhao novelbiocompatiblezrbasedalloywithlowyoungsmodulusandmagneticsusceptibilityforbiomedicalimplants
AT wangdong novelbiocompatiblezrbasedalloywithlowyoungsmodulusandmagneticsusceptibilityforbiomedicalimplants
AT yangdawei novelbiocompatiblezrbasedalloywithlowyoungsmodulusandmagneticsusceptibilityforbiomedicalimplants
AT zhangligang novelbiocompatiblezrbasedalloywithlowyoungsmodulusandmagneticsusceptibilityforbiomedicalimplants
AT xuxiaoning novelbiocompatiblezrbasedalloywithlowyoungsmodulusandmagneticsusceptibilityforbiomedicalimplants
AT liulibin novelbiocompatiblezrbasedalloywithlowyoungsmodulusandmagneticsusceptibilityforbiomedicalimplants
AT wudi novelbiocompatiblezrbasedalloywithlowyoungsmodulusandmagneticsusceptibilityforbiomedicalimplants