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Porphyromonas gingivalis and Its Systemic Impact: Current Status

The relationship between periodontitis and systemic diseases, notably including atherosclerosis and diabetes, has been studied for several years. Porphyromonas gingivalis, a prominent component of oral microorganism communities, is the main pathogen that causes periodontitis. As a result of the exte...

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Autores principales: Mei, Feng, Xie, Mengru, Huang, Xiaofei, Long, Yanlin, Lu, Xiaofeng, Wang, Xiaoli, Chen, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696708/
https://www.ncbi.nlm.nih.gov/pubmed/33202751
http://dx.doi.org/10.3390/pathogens9110944
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author Mei, Feng
Xie, Mengru
Huang, Xiaofei
Long, Yanlin
Lu, Xiaofeng
Wang, Xiaoli
Chen, Lili
author_facet Mei, Feng
Xie, Mengru
Huang, Xiaofei
Long, Yanlin
Lu, Xiaofeng
Wang, Xiaoli
Chen, Lili
author_sort Mei, Feng
collection PubMed
description The relationship between periodontitis and systemic diseases, notably including atherosclerosis and diabetes, has been studied for several years. Porphyromonas gingivalis, a prominent component of oral microorganism communities, is the main pathogen that causes periodontitis. As a result of the extensive analysis of this organism, the evidence of its connection to systemic diseases has become more apparent over the last decade. A significant amount of research has explored the role of Porphyromonas gingivalis in atherosclerosis, Alzheimer’s disease, rheumatoid arthritis, diabetes, and adverse pregnancy outcomes, while relatively few studies have examined its contribution to respiratory diseases, nonalcoholic fatty liver disease, and depression. Here, we provide an overview of the current state of knowledge about Porphyromonas gingivalis and its systemic impact in an aim to inform readers of the existing epidemiological evidence and the most recent preclinical studies. Additionally, the possible mechanisms by which Porphyromonas gingivalis is involved in the onset or exacerbation of diseases, together with its effects on systemic health, are covered. Although a few results remain controversial, it is now evident that Porphyromonas gingivalis should be regarded as a modifiable factor for several diseases.
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spelling pubmed-76967082020-11-29 Porphyromonas gingivalis and Its Systemic Impact: Current Status Mei, Feng Xie, Mengru Huang, Xiaofei Long, Yanlin Lu, Xiaofeng Wang, Xiaoli Chen, Lili Pathogens Review The relationship between periodontitis and systemic diseases, notably including atherosclerosis and diabetes, has been studied for several years. Porphyromonas gingivalis, a prominent component of oral microorganism communities, is the main pathogen that causes periodontitis. As a result of the extensive analysis of this organism, the evidence of its connection to systemic diseases has become more apparent over the last decade. A significant amount of research has explored the role of Porphyromonas gingivalis in atherosclerosis, Alzheimer’s disease, rheumatoid arthritis, diabetes, and adverse pregnancy outcomes, while relatively few studies have examined its contribution to respiratory diseases, nonalcoholic fatty liver disease, and depression. Here, we provide an overview of the current state of knowledge about Porphyromonas gingivalis and its systemic impact in an aim to inform readers of the existing epidemiological evidence and the most recent preclinical studies. Additionally, the possible mechanisms by which Porphyromonas gingivalis is involved in the onset or exacerbation of diseases, together with its effects on systemic health, are covered. Although a few results remain controversial, it is now evident that Porphyromonas gingivalis should be regarded as a modifiable factor for several diseases. MDPI 2020-11-13 /pmc/articles/PMC7696708/ /pubmed/33202751 http://dx.doi.org/10.3390/pathogens9110944 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mei, Feng
Xie, Mengru
Huang, Xiaofei
Long, Yanlin
Lu, Xiaofeng
Wang, Xiaoli
Chen, Lili
Porphyromonas gingivalis and Its Systemic Impact: Current Status
title Porphyromonas gingivalis and Its Systemic Impact: Current Status
title_full Porphyromonas gingivalis and Its Systemic Impact: Current Status
title_fullStr Porphyromonas gingivalis and Its Systemic Impact: Current Status
title_full_unstemmed Porphyromonas gingivalis and Its Systemic Impact: Current Status
title_short Porphyromonas gingivalis and Its Systemic Impact: Current Status
title_sort porphyromonas gingivalis and its systemic impact: current status
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696708/
https://www.ncbi.nlm.nih.gov/pubmed/33202751
http://dx.doi.org/10.3390/pathogens9110944
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