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Cachexia, a Systemic Disease beyond Muscle Atrophy

Cachexia is a complication of dismal prognosis, which often represents the last step of several chronic diseases. For this reason, the comprehension of the molecular drivers of such a condition is crucial for the development of management approaches. Importantly, cachexia is a syndrome affecting var...

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Detalles Bibliográficos
Autores principales: Wyart, Elisabeth, Bindels, Laure B., Mina, Erica, Menga, Alessio, Stanga, Serena, Porporato, Paolo E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696729/
https://www.ncbi.nlm.nih.gov/pubmed/33202621
http://dx.doi.org/10.3390/ijms21228592
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author Wyart, Elisabeth
Bindels, Laure B.
Mina, Erica
Menga, Alessio
Stanga, Serena
Porporato, Paolo E.
author_facet Wyart, Elisabeth
Bindels, Laure B.
Mina, Erica
Menga, Alessio
Stanga, Serena
Porporato, Paolo E.
author_sort Wyart, Elisabeth
collection PubMed
description Cachexia is a complication of dismal prognosis, which often represents the last step of several chronic diseases. For this reason, the comprehension of the molecular drivers of such a condition is crucial for the development of management approaches. Importantly, cachexia is a syndrome affecting various organs, which often results in systemic complications. To date, the majority of the research on cachexia has been focused on skeletal muscle, muscle atrophy being a pivotal cause of weight loss and the major feature associated with the steep reduction in quality of life. Nevertheless, defining the impact of cachexia on other organs is essential to properly comprehend the complexity of such a condition and potentially develop novel therapeutic approaches.
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spelling pubmed-76967292020-11-29 Cachexia, a Systemic Disease beyond Muscle Atrophy Wyart, Elisabeth Bindels, Laure B. Mina, Erica Menga, Alessio Stanga, Serena Porporato, Paolo E. Int J Mol Sci Review Cachexia is a complication of dismal prognosis, which often represents the last step of several chronic diseases. For this reason, the comprehension of the molecular drivers of such a condition is crucial for the development of management approaches. Importantly, cachexia is a syndrome affecting various organs, which often results in systemic complications. To date, the majority of the research on cachexia has been focused on skeletal muscle, muscle atrophy being a pivotal cause of weight loss and the major feature associated with the steep reduction in quality of life. Nevertheless, defining the impact of cachexia on other organs is essential to properly comprehend the complexity of such a condition and potentially develop novel therapeutic approaches. MDPI 2020-11-14 /pmc/articles/PMC7696729/ /pubmed/33202621 http://dx.doi.org/10.3390/ijms21228592 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wyart, Elisabeth
Bindels, Laure B.
Mina, Erica
Menga, Alessio
Stanga, Serena
Porporato, Paolo E.
Cachexia, a Systemic Disease beyond Muscle Atrophy
title Cachexia, a Systemic Disease beyond Muscle Atrophy
title_full Cachexia, a Systemic Disease beyond Muscle Atrophy
title_fullStr Cachexia, a Systemic Disease beyond Muscle Atrophy
title_full_unstemmed Cachexia, a Systemic Disease beyond Muscle Atrophy
title_short Cachexia, a Systemic Disease beyond Muscle Atrophy
title_sort cachexia, a systemic disease beyond muscle atrophy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696729/
https://www.ncbi.nlm.nih.gov/pubmed/33202621
http://dx.doi.org/10.3390/ijms21228592
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