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Cachexia, a Systemic Disease beyond Muscle Atrophy
Cachexia is a complication of dismal prognosis, which often represents the last step of several chronic diseases. For this reason, the comprehension of the molecular drivers of such a condition is crucial for the development of management approaches. Importantly, cachexia is a syndrome affecting var...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696729/ https://www.ncbi.nlm.nih.gov/pubmed/33202621 http://dx.doi.org/10.3390/ijms21228592 |
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author | Wyart, Elisabeth Bindels, Laure B. Mina, Erica Menga, Alessio Stanga, Serena Porporato, Paolo E. |
author_facet | Wyart, Elisabeth Bindels, Laure B. Mina, Erica Menga, Alessio Stanga, Serena Porporato, Paolo E. |
author_sort | Wyart, Elisabeth |
collection | PubMed |
description | Cachexia is a complication of dismal prognosis, which often represents the last step of several chronic diseases. For this reason, the comprehension of the molecular drivers of such a condition is crucial for the development of management approaches. Importantly, cachexia is a syndrome affecting various organs, which often results in systemic complications. To date, the majority of the research on cachexia has been focused on skeletal muscle, muscle atrophy being a pivotal cause of weight loss and the major feature associated with the steep reduction in quality of life. Nevertheless, defining the impact of cachexia on other organs is essential to properly comprehend the complexity of such a condition and potentially develop novel therapeutic approaches. |
format | Online Article Text |
id | pubmed-7696729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76967292020-11-29 Cachexia, a Systemic Disease beyond Muscle Atrophy Wyart, Elisabeth Bindels, Laure B. Mina, Erica Menga, Alessio Stanga, Serena Porporato, Paolo E. Int J Mol Sci Review Cachexia is a complication of dismal prognosis, which often represents the last step of several chronic diseases. For this reason, the comprehension of the molecular drivers of such a condition is crucial for the development of management approaches. Importantly, cachexia is a syndrome affecting various organs, which often results in systemic complications. To date, the majority of the research on cachexia has been focused on skeletal muscle, muscle atrophy being a pivotal cause of weight loss and the major feature associated with the steep reduction in quality of life. Nevertheless, defining the impact of cachexia on other organs is essential to properly comprehend the complexity of such a condition and potentially develop novel therapeutic approaches. MDPI 2020-11-14 /pmc/articles/PMC7696729/ /pubmed/33202621 http://dx.doi.org/10.3390/ijms21228592 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wyart, Elisabeth Bindels, Laure B. Mina, Erica Menga, Alessio Stanga, Serena Porporato, Paolo E. Cachexia, a Systemic Disease beyond Muscle Atrophy |
title | Cachexia, a Systemic Disease beyond Muscle Atrophy |
title_full | Cachexia, a Systemic Disease beyond Muscle Atrophy |
title_fullStr | Cachexia, a Systemic Disease beyond Muscle Atrophy |
title_full_unstemmed | Cachexia, a Systemic Disease beyond Muscle Atrophy |
title_short | Cachexia, a Systemic Disease beyond Muscle Atrophy |
title_sort | cachexia, a systemic disease beyond muscle atrophy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696729/ https://www.ncbi.nlm.nih.gov/pubmed/33202621 http://dx.doi.org/10.3390/ijms21228592 |
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