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Pharmacogenomics for Primary Care: An Overview
Most of the prescribing and dispensing of medicines happens in primary care. Pharmacogenomics (PGx) is the study and clinical application of the role of genetic variation on drug response. Mounting evidence suggests PGx can improve the safety and/or efficacy of several medications commonly prescribe...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696803/ https://www.ncbi.nlm.nih.gov/pubmed/33198260 http://dx.doi.org/10.3390/genes11111337 |
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author | Rollinson, Victoria Turner, Richard Pirmohamed, Munir |
author_facet | Rollinson, Victoria Turner, Richard Pirmohamed, Munir |
author_sort | Rollinson, Victoria |
collection | PubMed |
description | Most of the prescribing and dispensing of medicines happens in primary care. Pharmacogenomics (PGx) is the study and clinical application of the role of genetic variation on drug response. Mounting evidence suggests PGx can improve the safety and/or efficacy of several medications commonly prescribed in primary care. However, implementation of PGx has generally been limited to a relatively few academic hospital centres, with little adoption in primary care. Despite this, many primary healthcare providers are optimistic about the role of PGx in their future practice. The increasing prevalence of direct-to-consumer genetic testing and primary care PGx studies herald the plausible gradual introduction of PGx into primary care and highlight the changes needed for optimal translation. In this article, the potential utility of PGx in primary care will be explored and on-going barriers to implementation discussed. The evidence base of several drug-gene pairs relevant to primary care will be outlined with a focus on antidepressants, codeine and tramadol, statins, clopidogrel, warfarin, metoprolol and allopurinol. This review is intended to provide both a general introduction to PGx with a more in-depth overview of elements relevant to primary care. |
format | Online Article Text |
id | pubmed-7696803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76968032020-11-29 Pharmacogenomics for Primary Care: An Overview Rollinson, Victoria Turner, Richard Pirmohamed, Munir Genes (Basel) Review Most of the prescribing and dispensing of medicines happens in primary care. Pharmacogenomics (PGx) is the study and clinical application of the role of genetic variation on drug response. Mounting evidence suggests PGx can improve the safety and/or efficacy of several medications commonly prescribed in primary care. However, implementation of PGx has generally been limited to a relatively few academic hospital centres, with little adoption in primary care. Despite this, many primary healthcare providers are optimistic about the role of PGx in their future practice. The increasing prevalence of direct-to-consumer genetic testing and primary care PGx studies herald the plausible gradual introduction of PGx into primary care and highlight the changes needed for optimal translation. In this article, the potential utility of PGx in primary care will be explored and on-going barriers to implementation discussed. The evidence base of several drug-gene pairs relevant to primary care will be outlined with a focus on antidepressants, codeine and tramadol, statins, clopidogrel, warfarin, metoprolol and allopurinol. This review is intended to provide both a general introduction to PGx with a more in-depth overview of elements relevant to primary care. MDPI 2020-11-12 /pmc/articles/PMC7696803/ /pubmed/33198260 http://dx.doi.org/10.3390/genes11111337 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rollinson, Victoria Turner, Richard Pirmohamed, Munir Pharmacogenomics for Primary Care: An Overview |
title | Pharmacogenomics for Primary Care: An Overview |
title_full | Pharmacogenomics for Primary Care: An Overview |
title_fullStr | Pharmacogenomics for Primary Care: An Overview |
title_full_unstemmed | Pharmacogenomics for Primary Care: An Overview |
title_short | Pharmacogenomics for Primary Care: An Overview |
title_sort | pharmacogenomics for primary care: an overview |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696803/ https://www.ncbi.nlm.nih.gov/pubmed/33198260 http://dx.doi.org/10.3390/genes11111337 |
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