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Scavenger Receptors as Biomarkers and Therapeutic Targets in Cardiovascular Disease

The process of atherosclerosis leads to the formation of plaques in the arterial wall, resulting in a decreased blood supply to tissues and organs and its sequelae: morbidity and mortality. A class of membrane-bound proteins termed scavenger receptors (SRs) are closely linked to the initiation and p...

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Autores principales: Cuthbert, Gary A., Shaik, Faheem, Harrison, Michael A., Ponnambalam, Sreenivasan, Homer-Vanniasinkam, Shervanthi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696859/
https://www.ncbi.nlm.nih.gov/pubmed/33182772
http://dx.doi.org/10.3390/cells9112453
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author Cuthbert, Gary A.
Shaik, Faheem
Harrison, Michael A.
Ponnambalam, Sreenivasan
Homer-Vanniasinkam, Shervanthi
author_facet Cuthbert, Gary A.
Shaik, Faheem
Harrison, Michael A.
Ponnambalam, Sreenivasan
Homer-Vanniasinkam, Shervanthi
author_sort Cuthbert, Gary A.
collection PubMed
description The process of atherosclerosis leads to the formation of plaques in the arterial wall, resulting in a decreased blood supply to tissues and organs and its sequelae: morbidity and mortality. A class of membrane-bound proteins termed scavenger receptors (SRs) are closely linked to the initiation and progression of atherosclerosis. Increasing interest in understanding SR structure and function has led to the idea that these proteins could provide new routes for cardiovascular disease diagnosis, management, and treatment. In this review, we consider the main classes of SRs that are implicated in arterial disease. We consider how our understanding of SR-mediated recognition of diverse ligands, including modified lipid particles, lipids, and carbohydrates, has enabled us to better target SR-linked functionality in disease. We also link clinical studies on vascular disease to our current understanding of SR biology and highlight potential areas that are relevant to cardiovascular disease management and therapy.
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spelling pubmed-76968592020-11-29 Scavenger Receptors as Biomarkers and Therapeutic Targets in Cardiovascular Disease Cuthbert, Gary A. Shaik, Faheem Harrison, Michael A. Ponnambalam, Sreenivasan Homer-Vanniasinkam, Shervanthi Cells Review The process of atherosclerosis leads to the formation of plaques in the arterial wall, resulting in a decreased blood supply to tissues and organs and its sequelae: morbidity and mortality. A class of membrane-bound proteins termed scavenger receptors (SRs) are closely linked to the initiation and progression of atherosclerosis. Increasing interest in understanding SR structure and function has led to the idea that these proteins could provide new routes for cardiovascular disease diagnosis, management, and treatment. In this review, we consider the main classes of SRs that are implicated in arterial disease. We consider how our understanding of SR-mediated recognition of diverse ligands, including modified lipid particles, lipids, and carbohydrates, has enabled us to better target SR-linked functionality in disease. We also link clinical studies on vascular disease to our current understanding of SR biology and highlight potential areas that are relevant to cardiovascular disease management and therapy. MDPI 2020-11-10 /pmc/articles/PMC7696859/ /pubmed/33182772 http://dx.doi.org/10.3390/cells9112453 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cuthbert, Gary A.
Shaik, Faheem
Harrison, Michael A.
Ponnambalam, Sreenivasan
Homer-Vanniasinkam, Shervanthi
Scavenger Receptors as Biomarkers and Therapeutic Targets in Cardiovascular Disease
title Scavenger Receptors as Biomarkers and Therapeutic Targets in Cardiovascular Disease
title_full Scavenger Receptors as Biomarkers and Therapeutic Targets in Cardiovascular Disease
title_fullStr Scavenger Receptors as Biomarkers and Therapeutic Targets in Cardiovascular Disease
title_full_unstemmed Scavenger Receptors as Biomarkers and Therapeutic Targets in Cardiovascular Disease
title_short Scavenger Receptors as Biomarkers and Therapeutic Targets in Cardiovascular Disease
title_sort scavenger receptors as biomarkers and therapeutic targets in cardiovascular disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696859/
https://www.ncbi.nlm.nih.gov/pubmed/33182772
http://dx.doi.org/10.3390/cells9112453
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