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Recurrence Pattern of Cervical Cancer Based on the Platinum Sensitivity Concept: A Multi-Institutional Study from the FRANCOGYN Group

The standard of care for patients with advanced cervical cancer (ACC) includes platinum-based chemotherapy. The concept of platinum sensitivity is a major prognostic factor for patients with ovarian cancer. The aim of this study was to validate the applicability of the platinum sensitivity concept t...

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Autores principales: de Foucher, Tiphaine, Hennebert, Cecile, Dabi, Yohan, Ouldamer, Lobna, Lavoué, Vincent, Dion, Ludivine, Canlorbe, Geoffroy, Bolze, Pierre Adrien, Golfier, François, Akladios, Cherif, Lecointre, Lise, Kerbage, Yohan, Collinet, Pierre, Bricou, Alexandre, Carcopino, Xavier, Huchon, Cyrille, Raimond, Emilie, Graesslin, Olivier, Owen, Clémentine, Touboul, Cyril, Ballester, Marcos, Darai, Emile, Bendifallah, Sofiane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696862/
https://www.ncbi.nlm.nih.gov/pubmed/33198384
http://dx.doi.org/10.3390/jcm9113646
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author de Foucher, Tiphaine
Hennebert, Cecile
Dabi, Yohan
Ouldamer, Lobna
Lavoué, Vincent
Dion, Ludivine
Canlorbe, Geoffroy
Bolze, Pierre Adrien
Golfier, François
Akladios, Cherif
Lecointre, Lise
Kerbage, Yohan
Collinet, Pierre
Bricou, Alexandre
Carcopino, Xavier
Huchon, Cyrille
Raimond, Emilie
Graesslin, Olivier
Owen, Clémentine
Touboul, Cyril
Ballester, Marcos
Darai, Emile
Bendifallah, Sofiane
author_facet de Foucher, Tiphaine
Hennebert, Cecile
Dabi, Yohan
Ouldamer, Lobna
Lavoué, Vincent
Dion, Ludivine
Canlorbe, Geoffroy
Bolze, Pierre Adrien
Golfier, François
Akladios, Cherif
Lecointre, Lise
Kerbage, Yohan
Collinet, Pierre
Bricou, Alexandre
Carcopino, Xavier
Huchon, Cyrille
Raimond, Emilie
Graesslin, Olivier
Owen, Clémentine
Touboul, Cyril
Ballester, Marcos
Darai, Emile
Bendifallah, Sofiane
author_sort de Foucher, Tiphaine
collection PubMed
description The standard of care for patients with advanced cervical cancer (ACC) includes platinum-based chemotherapy. The concept of platinum sensitivity is a major prognostic factor for patients with ovarian cancer. The aim of this study was to validate the applicability of the platinum sensitivity concept to ACC patients, and to estimate its prognostic interest in terms of overall survival (OS) and pattern of recurrence (location, timing). Data of women with histologically proven FIGO 2019 stages IB3–IV ACC, treated between May 2000 and November 2017 with platinum-based regimens, were retrospectively abstracted from 12 institutions from the FRANCOGYN Group. Respective 3-year OSs were 52% (95% CI: 40.8%–66.8%), 21.6% (95% CI: 12.6%–37.2%), and 14.6% (95% CI: 4.2%–50.2%), in case of recurrence <6 months, between 6 and 17 months, and ≥18 months (p < 0.001). Risk of metastatic or multisite recurrence was significantly higher in case of recurrence <6 months, and risk of local or isolated infradiaphragmatic nodal recurrence was significantly higher in case of recurrence >18 months (p < 0.001). In multivariate analysis, platinum sensitivity status was a strong prognostic factor for OS after recurrence, independent of histological grade, lympho-vascular space involvement, final lymph node status, and treatment. Platinum sensitivity status may help to classify patients in three prognostic subgroups for OS after recurrence, and appears to be a strong prognostic factor correlated to the pattern of recurrence.
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spelling pubmed-76968622020-11-29 Recurrence Pattern of Cervical Cancer Based on the Platinum Sensitivity Concept: A Multi-Institutional Study from the FRANCOGYN Group de Foucher, Tiphaine Hennebert, Cecile Dabi, Yohan Ouldamer, Lobna Lavoué, Vincent Dion, Ludivine Canlorbe, Geoffroy Bolze, Pierre Adrien Golfier, François Akladios, Cherif Lecointre, Lise Kerbage, Yohan Collinet, Pierre Bricou, Alexandre Carcopino, Xavier Huchon, Cyrille Raimond, Emilie Graesslin, Olivier Owen, Clémentine Touboul, Cyril Ballester, Marcos Darai, Emile Bendifallah, Sofiane J Clin Med Article The standard of care for patients with advanced cervical cancer (ACC) includes platinum-based chemotherapy. The concept of platinum sensitivity is a major prognostic factor for patients with ovarian cancer. The aim of this study was to validate the applicability of the platinum sensitivity concept to ACC patients, and to estimate its prognostic interest in terms of overall survival (OS) and pattern of recurrence (location, timing). Data of women with histologically proven FIGO 2019 stages IB3–IV ACC, treated between May 2000 and November 2017 with platinum-based regimens, were retrospectively abstracted from 12 institutions from the FRANCOGYN Group. Respective 3-year OSs were 52% (95% CI: 40.8%–66.8%), 21.6% (95% CI: 12.6%–37.2%), and 14.6% (95% CI: 4.2%–50.2%), in case of recurrence <6 months, between 6 and 17 months, and ≥18 months (p < 0.001). Risk of metastatic or multisite recurrence was significantly higher in case of recurrence <6 months, and risk of local or isolated infradiaphragmatic nodal recurrence was significantly higher in case of recurrence >18 months (p < 0.001). In multivariate analysis, platinum sensitivity status was a strong prognostic factor for OS after recurrence, independent of histological grade, lympho-vascular space involvement, final lymph node status, and treatment. Platinum sensitivity status may help to classify patients in three prognostic subgroups for OS after recurrence, and appears to be a strong prognostic factor correlated to the pattern of recurrence. MDPI 2020-11-12 /pmc/articles/PMC7696862/ /pubmed/33198384 http://dx.doi.org/10.3390/jcm9113646 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Foucher, Tiphaine
Hennebert, Cecile
Dabi, Yohan
Ouldamer, Lobna
Lavoué, Vincent
Dion, Ludivine
Canlorbe, Geoffroy
Bolze, Pierre Adrien
Golfier, François
Akladios, Cherif
Lecointre, Lise
Kerbage, Yohan
Collinet, Pierre
Bricou, Alexandre
Carcopino, Xavier
Huchon, Cyrille
Raimond, Emilie
Graesslin, Olivier
Owen, Clémentine
Touboul, Cyril
Ballester, Marcos
Darai, Emile
Bendifallah, Sofiane
Recurrence Pattern of Cervical Cancer Based on the Platinum Sensitivity Concept: A Multi-Institutional Study from the FRANCOGYN Group
title Recurrence Pattern of Cervical Cancer Based on the Platinum Sensitivity Concept: A Multi-Institutional Study from the FRANCOGYN Group
title_full Recurrence Pattern of Cervical Cancer Based on the Platinum Sensitivity Concept: A Multi-Institutional Study from the FRANCOGYN Group
title_fullStr Recurrence Pattern of Cervical Cancer Based on the Platinum Sensitivity Concept: A Multi-Institutional Study from the FRANCOGYN Group
title_full_unstemmed Recurrence Pattern of Cervical Cancer Based on the Platinum Sensitivity Concept: A Multi-Institutional Study from the FRANCOGYN Group
title_short Recurrence Pattern of Cervical Cancer Based on the Platinum Sensitivity Concept: A Multi-Institutional Study from the FRANCOGYN Group
title_sort recurrence pattern of cervical cancer based on the platinum sensitivity concept: a multi-institutional study from the francogyn group
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696862/
https://www.ncbi.nlm.nih.gov/pubmed/33198384
http://dx.doi.org/10.3390/jcm9113646
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