Clinical Features and Pathogenic Mechanisms of Gastrointestinal Injury in COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global coronavirus disease 2019 (COVID-19) outbreak. Along with the respiratory tract, the gastrointestinal (GI) tract is one of the main extra-pulmonary targets of SARS-CoV-2 with respect to symptom occurrence and is a...

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Autores principales: Mitsuyama, Keiichi, Tsuruta, Kozo, Takedatsu, Hidetoshi, Yoshioka, Shinichiro, Morita, Masaru, Niwa, Mikio, Matsumoto, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696882/
https://www.ncbi.nlm.nih.gov/pubmed/33187280
http://dx.doi.org/10.3390/jcm9113630
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author Mitsuyama, Keiichi
Tsuruta, Kozo
Takedatsu, Hidetoshi
Yoshioka, Shinichiro
Morita, Masaru
Niwa, Mikio
Matsumoto, Satoshi
author_facet Mitsuyama, Keiichi
Tsuruta, Kozo
Takedatsu, Hidetoshi
Yoshioka, Shinichiro
Morita, Masaru
Niwa, Mikio
Matsumoto, Satoshi
author_sort Mitsuyama, Keiichi
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global coronavirus disease 2019 (COVID-19) outbreak. Along with the respiratory tract, the gastrointestinal (GI) tract is one of the main extra-pulmonary targets of SARS-CoV-2 with respect to symptom occurrence and is a potential route for virus transmission, most likely due to the presence of angiotensin-converting enzyme 2. Therefore, understanding the mechanisms of GI injury is crucial for a harmonized therapeutic strategy against COVID-19. This review summarizes the current evidence for the clinical features of and possible pathogenic mechanisms leading to GI injury in COVID-19.
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spelling pubmed-76968822020-11-29 Clinical Features and Pathogenic Mechanisms of Gastrointestinal Injury in COVID-19 Mitsuyama, Keiichi Tsuruta, Kozo Takedatsu, Hidetoshi Yoshioka, Shinichiro Morita, Masaru Niwa, Mikio Matsumoto, Satoshi J Clin Med Review Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global coronavirus disease 2019 (COVID-19) outbreak. Along with the respiratory tract, the gastrointestinal (GI) tract is one of the main extra-pulmonary targets of SARS-CoV-2 with respect to symptom occurrence and is a potential route for virus transmission, most likely due to the presence of angiotensin-converting enzyme 2. Therefore, understanding the mechanisms of GI injury is crucial for a harmonized therapeutic strategy against COVID-19. This review summarizes the current evidence for the clinical features of and possible pathogenic mechanisms leading to GI injury in COVID-19. MDPI 2020-11-11 /pmc/articles/PMC7696882/ /pubmed/33187280 http://dx.doi.org/10.3390/jcm9113630 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mitsuyama, Keiichi
Tsuruta, Kozo
Takedatsu, Hidetoshi
Yoshioka, Shinichiro
Morita, Masaru
Niwa, Mikio
Matsumoto, Satoshi
Clinical Features and Pathogenic Mechanisms of Gastrointestinal Injury in COVID-19
title Clinical Features and Pathogenic Mechanisms of Gastrointestinal Injury in COVID-19
title_full Clinical Features and Pathogenic Mechanisms of Gastrointestinal Injury in COVID-19
title_fullStr Clinical Features and Pathogenic Mechanisms of Gastrointestinal Injury in COVID-19
title_full_unstemmed Clinical Features and Pathogenic Mechanisms of Gastrointestinal Injury in COVID-19
title_short Clinical Features and Pathogenic Mechanisms of Gastrointestinal Injury in COVID-19
title_sort clinical features and pathogenic mechanisms of gastrointestinal injury in covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696882/
https://www.ncbi.nlm.nih.gov/pubmed/33187280
http://dx.doi.org/10.3390/jcm9113630
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