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Acute Kidney Injury is Associated with Lowered Plasma-Free Thiol Levels

Acute kidney injury (AKI) is associated with the abrupt loss of kidney function. Oxidative stress plays an important role in the pathophysiology of AKI. Free thiols (R-SH) are crucial components of the extracellular antioxidant machinery and reliably reflect systemic oxidative stress. Lower levels o...

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Autores principales: Boekhoud, Lisanne, Koeze, Jacqueline, van der Slikke, Elisabeth C., Bourgonje, Arno R., Moser, Jill, Zijlstra, Jan G., Muller Kobold, Anneke C., Bulthuis, Marian L. C., van Meurs, Matijs, van Goor, Harry, Bouma, Hjalmar R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696918/
https://www.ncbi.nlm.nih.gov/pubmed/33207555
http://dx.doi.org/10.3390/antiox9111135
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author Boekhoud, Lisanne
Koeze, Jacqueline
van der Slikke, Elisabeth C.
Bourgonje, Arno R.
Moser, Jill
Zijlstra, Jan G.
Muller Kobold, Anneke C.
Bulthuis, Marian L. C.
van Meurs, Matijs
van Goor, Harry
Bouma, Hjalmar R.
author_facet Boekhoud, Lisanne
Koeze, Jacqueline
van der Slikke, Elisabeth C.
Bourgonje, Arno R.
Moser, Jill
Zijlstra, Jan G.
Muller Kobold, Anneke C.
Bulthuis, Marian L. C.
van Meurs, Matijs
van Goor, Harry
Bouma, Hjalmar R.
author_sort Boekhoud, Lisanne
collection PubMed
description Acute kidney injury (AKI) is associated with the abrupt loss of kidney function. Oxidative stress plays an important role in the pathophysiology of AKI. Free thiols (R-SH) are crucial components of the extracellular antioxidant machinery and reliably reflect systemic oxidative stress. Lower levels of thiols represent higher levels of oxidative stress. In this preliminary study, we hypothesized that plasma-free thiols are associated with AKI upon admission to the intensive care unit (ICU). In this study, 301 critically ill patients were included. Plasma samples were taken upon admission, and albumin-adjusted plasma-free thiols were determined. Albumin-adjusted plasma-free thiols were lower in patients with AKI (n = 43, median (interquartile range) 7.28 µmol/g (3.52, 8.95)) compared to patients without AKI (8.50 μmol/g (5.82, 11.28); p < 0.05) upon admission to the ICU. Higher age (B = −0.72), higher levels of neutrophil gelatinase-associated lipocalin (B = −0.002), creatinine (B = −0.01) and lower serum albumin (B = 0.47) were associated with lower free thiol levels. Further, albumin-adjusted free thiol levels were significantly reduced in patients with sepsis (8.30 (5.52–10.64) µmol/g) compared to patients without sepsis (6.95 (3.72–8.92) µmol/g; p < 0.05). Together, albumin-adjusted plasma-free thiols were significantly reduced in patients with AKI and patients with sepsis compared with patients without AKI and sepsis.
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spelling pubmed-76969182020-11-29 Acute Kidney Injury is Associated with Lowered Plasma-Free Thiol Levels Boekhoud, Lisanne Koeze, Jacqueline van der Slikke, Elisabeth C. Bourgonje, Arno R. Moser, Jill Zijlstra, Jan G. Muller Kobold, Anneke C. Bulthuis, Marian L. C. van Meurs, Matijs van Goor, Harry Bouma, Hjalmar R. Antioxidants (Basel) Article Acute kidney injury (AKI) is associated with the abrupt loss of kidney function. Oxidative stress plays an important role in the pathophysiology of AKI. Free thiols (R-SH) are crucial components of the extracellular antioxidant machinery and reliably reflect systemic oxidative stress. Lower levels of thiols represent higher levels of oxidative stress. In this preliminary study, we hypothesized that plasma-free thiols are associated with AKI upon admission to the intensive care unit (ICU). In this study, 301 critically ill patients were included. Plasma samples were taken upon admission, and albumin-adjusted plasma-free thiols were determined. Albumin-adjusted plasma-free thiols were lower in patients with AKI (n = 43, median (interquartile range) 7.28 µmol/g (3.52, 8.95)) compared to patients without AKI (8.50 μmol/g (5.82, 11.28); p < 0.05) upon admission to the ICU. Higher age (B = −0.72), higher levels of neutrophil gelatinase-associated lipocalin (B = −0.002), creatinine (B = −0.01) and lower serum albumin (B = 0.47) were associated with lower free thiol levels. Further, albumin-adjusted free thiol levels were significantly reduced in patients with sepsis (8.30 (5.52–10.64) µmol/g) compared to patients without sepsis (6.95 (3.72–8.92) µmol/g; p < 0.05). Together, albumin-adjusted plasma-free thiols were significantly reduced in patients with AKI and patients with sepsis compared with patients without AKI and sepsis. MDPI 2020-11-16 /pmc/articles/PMC7696918/ /pubmed/33207555 http://dx.doi.org/10.3390/antiox9111135 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Boekhoud, Lisanne
Koeze, Jacqueline
van der Slikke, Elisabeth C.
Bourgonje, Arno R.
Moser, Jill
Zijlstra, Jan G.
Muller Kobold, Anneke C.
Bulthuis, Marian L. C.
van Meurs, Matijs
van Goor, Harry
Bouma, Hjalmar R.
Acute Kidney Injury is Associated with Lowered Plasma-Free Thiol Levels
title Acute Kidney Injury is Associated with Lowered Plasma-Free Thiol Levels
title_full Acute Kidney Injury is Associated with Lowered Plasma-Free Thiol Levels
title_fullStr Acute Kidney Injury is Associated with Lowered Plasma-Free Thiol Levels
title_full_unstemmed Acute Kidney Injury is Associated with Lowered Plasma-Free Thiol Levels
title_short Acute Kidney Injury is Associated with Lowered Plasma-Free Thiol Levels
title_sort acute kidney injury is associated with lowered plasma-free thiol levels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696918/
https://www.ncbi.nlm.nih.gov/pubmed/33207555
http://dx.doi.org/10.3390/antiox9111135
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