Safety and Tolerability of SRX246, a Vasopressin 1a Antagonist, in Irritable Huntington’s Disease Patients—A Randomized Phase 2 Clinical Trial

SRX246 is a vasopressin (AVP) 1a receptor antagonist that crosses the blood-brain barrier. It reduced impulsive aggression, fear, depression and anxiety in animal models, blocked the actions of intranasal AVP on aggression/fear circuits in an experimental medicine fMRI study and demonstrated excelle...

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Detalles Bibliográficos
Autores principales: Brownstein, Michael J., Simon, Neal G., Long, Jeffrey D., Yankey, Jon, Maibach, Hilda T., Cudkowicz, Merit, Coffey, Christopher, Conwit, Robin A., Lungu, Codrin, Anderson, Karen E., Hersch, Steven M., Ecklund, Dixie J., Damiano, Eve M., Itzkowitz, Debra E., Lu, Shifang, Chase, Marianne K., Shefner, Jeremy M., McGarry, Andrew, Thornell, Brenda, Gladden, Catherine, Costigan, Michele, O’Suilleabhain, Padraig, Marshall, Frederick J., Chesire, Amy M., Deritis, Paul, Adams, Jamie L., Hedera, Peter, Lowen, Kelly, Rosas, H. Diana, Hiller, Amie L., Quinn, Joseph, Keith, Kellie, Duker, Andrew P., Gruenwald, Christina, Molloy, Angela, Jacob, Cara, Factor, Stewart, Sperin, Elaine, Bega, Danny, Brown, Zsazsa R., Seeberger, Lauren C., Sung, Victor W., Benge, Melanie, Kostyk, Sandra K., Daley, Allison M., Perlman, Susan, Suski, Valerie, Conlon, Patricia, Barrett, Matthew J., Lowenhaupt, Stephanie, Quigg, Mark, Perlmutter, Joel S., Wright, Brenton A., Most, Elaine, Schwartz, Guy J., Lamb, Jessica, Chuang, Rosalind S., Singer, Carlos, Marder, Karen, Moran, Joyce A., Singleton, John R., Zorn, Meghan, Wall, Paola V., Dubinsky, Richard M., Gray, Carolyn, Drazinic, Carolyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696926/
https://www.ncbi.nlm.nih.gov/pubmed/33207828
http://dx.doi.org/10.3390/jcm9113682

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