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Oxidative Stress and Preeclampsia-Associated Prothrombotic State
Preeclampsia (PE) is a common obstetric disease characterized by hypertension, proteinuria, and multi-system dysfunction. It endangers both maternal and fetal health. Although hemostasis is critical for preventing bleeding complications during pregnancy, delivery, and post-partum, PE patients often...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696949/ https://www.ncbi.nlm.nih.gov/pubmed/33212799 http://dx.doi.org/10.3390/antiox9111139 |
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author | Han, Cha Huang, Pengzhu Lyu, Meilu Dong, Jingfei |
author_facet | Han, Cha Huang, Pengzhu Lyu, Meilu Dong, Jingfei |
author_sort | Han, Cha |
collection | PubMed |
description | Preeclampsia (PE) is a common obstetric disease characterized by hypertension, proteinuria, and multi-system dysfunction. It endangers both maternal and fetal health. Although hemostasis is critical for preventing bleeding complications during pregnancy, delivery, and post-partum, PE patients often develop a severe prothrombotic state, potentially resulting in life-threatening thrombosis and thromboembolism. The cause of this thrombotic complication is multi-factorial, involving endothelial cells, platelets, adhesive ligands, coagulation, and fibrinolysis. Increasing evidence has shown that hemostatic cells and factors undergo oxidative modifications during the systemic inflammation found in PE patients. However, it is largely unknown how these oxidative modifications of hemostasis contribute to development of the PE-associated prothrombotic state. This knowledge gap has significantly hindered the development of predictive markers, preventive measures, and therapeutic agents to protect women during pregnancy. Here we summarize reports in the literature regarding the effects of oxidative stress and antioxidants on systemic hemostasis, with emphasis on the condition of PE. |
format | Online Article Text |
id | pubmed-7696949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76969492020-11-29 Oxidative Stress and Preeclampsia-Associated Prothrombotic State Han, Cha Huang, Pengzhu Lyu, Meilu Dong, Jingfei Antioxidants (Basel) Review Preeclampsia (PE) is a common obstetric disease characterized by hypertension, proteinuria, and multi-system dysfunction. It endangers both maternal and fetal health. Although hemostasis is critical for preventing bleeding complications during pregnancy, delivery, and post-partum, PE patients often develop a severe prothrombotic state, potentially resulting in life-threatening thrombosis and thromboembolism. The cause of this thrombotic complication is multi-factorial, involving endothelial cells, platelets, adhesive ligands, coagulation, and fibrinolysis. Increasing evidence has shown that hemostatic cells and factors undergo oxidative modifications during the systemic inflammation found in PE patients. However, it is largely unknown how these oxidative modifications of hemostasis contribute to development of the PE-associated prothrombotic state. This knowledge gap has significantly hindered the development of predictive markers, preventive measures, and therapeutic agents to protect women during pregnancy. Here we summarize reports in the literature regarding the effects of oxidative stress and antioxidants on systemic hemostasis, with emphasis on the condition of PE. MDPI 2020-11-17 /pmc/articles/PMC7696949/ /pubmed/33212799 http://dx.doi.org/10.3390/antiox9111139 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Han, Cha Huang, Pengzhu Lyu, Meilu Dong, Jingfei Oxidative Stress and Preeclampsia-Associated Prothrombotic State |
title | Oxidative Stress and Preeclampsia-Associated Prothrombotic State |
title_full | Oxidative Stress and Preeclampsia-Associated Prothrombotic State |
title_fullStr | Oxidative Stress and Preeclampsia-Associated Prothrombotic State |
title_full_unstemmed | Oxidative Stress and Preeclampsia-Associated Prothrombotic State |
title_short | Oxidative Stress and Preeclampsia-Associated Prothrombotic State |
title_sort | oxidative stress and preeclampsia-associated prothrombotic state |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696949/ https://www.ncbi.nlm.nih.gov/pubmed/33212799 http://dx.doi.org/10.3390/antiox9111139 |
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