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Health Outcomes at School Age among Children Who Are HIV-Exposed but Uninfected with Detected Mitochondrial DNA Depletion at One Year

Infant antiretroviral (ARV) prophylaxis given to children who are human immunodeficiency virus (HIV)-exposed but uninfected (CHEU) to prevent HIV transmission through breastfeeding previously proved its efficacy in the fight against the pediatric epidemic. However, few studies have investigated the...

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Autores principales: Monnin, Audrey, Nagot, Nicolas, Eymard-Duvernay, Sabrina, Meda, Nicolas, Tumwine, James K., Tylleskär, Thorkild, de Perre, Philippe Van, Molès, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696966/
https://www.ncbi.nlm.nih.gov/pubmed/33207772
http://dx.doi.org/10.3390/jcm9113680
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author Monnin, Audrey
Nagot, Nicolas
Eymard-Duvernay, Sabrina
Meda, Nicolas
Tumwine, James K.
Tylleskär, Thorkild
de Perre, Philippe Van
Molès, Jean-Pierre
author_facet Monnin, Audrey
Nagot, Nicolas
Eymard-Duvernay, Sabrina
Meda, Nicolas
Tumwine, James K.
Tylleskär, Thorkild
de Perre, Philippe Van
Molès, Jean-Pierre
author_sort Monnin, Audrey
collection PubMed
description Infant antiretroviral (ARV) prophylaxis given to children who are human immunodeficiency virus (HIV)-exposed but uninfected (CHEU) to prevent HIV transmission through breastfeeding previously proved its efficacy in the fight against the pediatric epidemic. However, few studies have investigated the short- and long-term safety of prophylactic regimens. We previously reported a decrease of mitochondrial DNA (mtDNA) content among CHEU who received one year of lamivudine (3TC) or lopinavir-boosted ritonavir (LPV/r) as infant prophylaxis. We aimed to describe mtDNA content at six years of age among these CHEU, including those for whom we identified mtDNA depletion at week 50 (decrease superior or equal to 50% from baseline), and to compare the two prophylactic drugs. We also addressed the association between mtDNA depletion at week 50 with growth, clinical, and neuropsychological outcomes at year 6. Quantitative PCR was used to measure mtDNA content in whole blood of CHEU seven days after birth, at week 50, and at year 6. Among CHEU with identified mtDNA depletion at week 50 (n = 17), only one had a persistent mtDNA content decrease at year 6. No difference between prophylactic drugs was observed. mtDNA depletion was not associated with growth, clinical, or neuropsychological outcomes at year 6. This study brought reassuring data concerning the safety of infant 3TC or LPV/r prophylaxis.
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spelling pubmed-76969662020-11-29 Health Outcomes at School Age among Children Who Are HIV-Exposed but Uninfected with Detected Mitochondrial DNA Depletion at One Year Monnin, Audrey Nagot, Nicolas Eymard-Duvernay, Sabrina Meda, Nicolas Tumwine, James K. Tylleskär, Thorkild de Perre, Philippe Van Molès, Jean-Pierre J Clin Med Article Infant antiretroviral (ARV) prophylaxis given to children who are human immunodeficiency virus (HIV)-exposed but uninfected (CHEU) to prevent HIV transmission through breastfeeding previously proved its efficacy in the fight against the pediatric epidemic. However, few studies have investigated the short- and long-term safety of prophylactic regimens. We previously reported a decrease of mitochondrial DNA (mtDNA) content among CHEU who received one year of lamivudine (3TC) or lopinavir-boosted ritonavir (LPV/r) as infant prophylaxis. We aimed to describe mtDNA content at six years of age among these CHEU, including those for whom we identified mtDNA depletion at week 50 (decrease superior or equal to 50% from baseline), and to compare the two prophylactic drugs. We also addressed the association between mtDNA depletion at week 50 with growth, clinical, and neuropsychological outcomes at year 6. Quantitative PCR was used to measure mtDNA content in whole blood of CHEU seven days after birth, at week 50, and at year 6. Among CHEU with identified mtDNA depletion at week 50 (n = 17), only one had a persistent mtDNA content decrease at year 6. No difference between prophylactic drugs was observed. mtDNA depletion was not associated with growth, clinical, or neuropsychological outcomes at year 6. This study brought reassuring data concerning the safety of infant 3TC or LPV/r prophylaxis. MDPI 2020-11-16 /pmc/articles/PMC7696966/ /pubmed/33207772 http://dx.doi.org/10.3390/jcm9113680 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Monnin, Audrey
Nagot, Nicolas
Eymard-Duvernay, Sabrina
Meda, Nicolas
Tumwine, James K.
Tylleskär, Thorkild
de Perre, Philippe Van
Molès, Jean-Pierre
Health Outcomes at School Age among Children Who Are HIV-Exposed but Uninfected with Detected Mitochondrial DNA Depletion at One Year
title Health Outcomes at School Age among Children Who Are HIV-Exposed but Uninfected with Detected Mitochondrial DNA Depletion at One Year
title_full Health Outcomes at School Age among Children Who Are HIV-Exposed but Uninfected with Detected Mitochondrial DNA Depletion at One Year
title_fullStr Health Outcomes at School Age among Children Who Are HIV-Exposed but Uninfected with Detected Mitochondrial DNA Depletion at One Year
title_full_unstemmed Health Outcomes at School Age among Children Who Are HIV-Exposed but Uninfected with Detected Mitochondrial DNA Depletion at One Year
title_short Health Outcomes at School Age among Children Who Are HIV-Exposed but Uninfected with Detected Mitochondrial DNA Depletion at One Year
title_sort health outcomes at school age among children who are hiv-exposed but uninfected with detected mitochondrial dna depletion at one year
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696966/
https://www.ncbi.nlm.nih.gov/pubmed/33207772
http://dx.doi.org/10.3390/jcm9113680
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