SARS-CoV-2 Vaccines: Inactivation by Gamma Irradiation for T and B Cell Immunity

Despite accumulating preclinical data demonstrating a crucial role of cytotoxic T cell immunity during viral infections, ongoing efforts on developing COVID-19 vaccines are mostly focused on antibodies. In this commentary article, we discuss potential benefits of cytotoxic T cells in providing long-...

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Detalles Bibliográficos
Autores principales: Mullbacher, Arno, Pardo, Julian, Furuya, Yoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697093/
https://www.ncbi.nlm.nih.gov/pubmed/33182546
http://dx.doi.org/10.3390/pathogens9110928
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author Mullbacher, Arno
Pardo, Julian
Furuya, Yoichi
author_facet Mullbacher, Arno
Pardo, Julian
Furuya, Yoichi
author_sort Mullbacher, Arno
collection PubMed
description Despite accumulating preclinical data demonstrating a crucial role of cytotoxic T cell immunity during viral infections, ongoing efforts on developing COVID-19 vaccines are mostly focused on antibodies. In this commentary article, we discuss potential benefits of cytotoxic T cells in providing long-term protection against COVID-19. Further, we propose that gamma-ray irradiation, which is a previously tested inactivation method, may be utilized to prepare an experimental COVID-19 vaccine that can provide balanced immunity involving both B and T cells.
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spelling pubmed-76970932020-11-29 SARS-CoV-2 Vaccines: Inactivation by Gamma Irradiation for T and B Cell Immunity Mullbacher, Arno Pardo, Julian Furuya, Yoichi Pathogens Opinion Despite accumulating preclinical data demonstrating a crucial role of cytotoxic T cell immunity during viral infections, ongoing efforts on developing COVID-19 vaccines are mostly focused on antibodies. In this commentary article, we discuss potential benefits of cytotoxic T cells in providing long-term protection against COVID-19. Further, we propose that gamma-ray irradiation, which is a previously tested inactivation method, may be utilized to prepare an experimental COVID-19 vaccine that can provide balanced immunity involving both B and T cells. MDPI 2020-11-10 /pmc/articles/PMC7697093/ /pubmed/33182546 http://dx.doi.org/10.3390/pathogens9110928 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Opinion
Mullbacher, Arno
Pardo, Julian
Furuya, Yoichi
SARS-CoV-2 Vaccines: Inactivation by Gamma Irradiation for T and B Cell Immunity
title SARS-CoV-2 Vaccines: Inactivation by Gamma Irradiation for T and B Cell Immunity
title_full SARS-CoV-2 Vaccines: Inactivation by Gamma Irradiation for T and B Cell Immunity
title_fullStr SARS-CoV-2 Vaccines: Inactivation by Gamma Irradiation for T and B Cell Immunity
title_full_unstemmed SARS-CoV-2 Vaccines: Inactivation by Gamma Irradiation for T and B Cell Immunity
title_short SARS-CoV-2 Vaccines: Inactivation by Gamma Irradiation for T and B Cell Immunity
title_sort sars-cov-2 vaccines: inactivation by gamma irradiation for t and b cell immunity
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697093/
https://www.ncbi.nlm.nih.gov/pubmed/33182546
http://dx.doi.org/10.3390/pathogens9110928
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