Simultaneous Induction of Glycolysis and Oxidative Phosphorylation during Activation of Hepatic Stellate Cells Reveals Novel Mitochondrial Targets to Treat Liver Fibrosis

Upon liver injury, hepatic stellate cells (HSCs) transdifferentiate to migratory, proliferative and extracellular matrix-producing myofibroblasts (e.g., activated HSCs; aHSCs) causing liver fibrosis. HSC activation is associated with increased glycolysis and glutaminolysis. Here, we compared the con...

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Detalles Bibliográficos
Autores principales: Smith-Cortinez, Natalia, van Eunen, Karen, Heegsma, Janette, Serna-Salas, Sandra Alejandra, Sydor, Svenja, Bechmann, Lars P., Moshage, Han, Bakker, Barbara M., Faber, Klaas Nico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697161/
https://www.ncbi.nlm.nih.gov/pubmed/33187083
http://dx.doi.org/10.3390/cells9112456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697161/
https://www.ncbi.nlm.nih.gov/pubmed/33187083
http://dx.doi.org/10.3390/cells9112456

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