Identification of Novel Influenza Polymerase PB2 Inhibitors Using a Cascade Docking Virtual Screening Approach

To discover novel inhibitors that target the influenza polymerase basic protein 2 (PB2) cap-binding domain (CBD), commercial ChemBridge compound libraries containing 384,796 compounds were screened using a cascade docking of LibDock–LigandFit–GOLD, and 60 compounds were selected for testing with cyt...

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Detalles Bibliográficos
Autores principales: Zhao, Lei, Che, Jinjing, Zhang, Qian, Li, Yiming, Guo, Xiaojia, Chen, Lixia, Li, Hua, Cao, Ruiyuan, Li, Xingzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697191/
https://www.ncbi.nlm.nih.gov/pubmed/33202790
http://dx.doi.org/10.3390/molecules25225291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697191/
https://www.ncbi.nlm.nih.gov/pubmed/33202790
http://dx.doi.org/10.3390/molecules25225291

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