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Sodium and Potassium Intake and Cardiovascular Disease in Older People: A Systematic Review

This review aims to examine the relationship of sodium and potassium intake and cardiovascular disease (CVD) among older people. Methods: We performed a literature search using PubMed and Web of Science (January 2015 to July 2020) without language restriction. Observational and experimental studies...

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Autores principales: Gonçalves, Carla, Abreu, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697211/
https://www.ncbi.nlm.nih.gov/pubmed/33182820
http://dx.doi.org/10.3390/nu12113447
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author Gonçalves, Carla
Abreu, Sandra
author_facet Gonçalves, Carla
Abreu, Sandra
author_sort Gonçalves, Carla
collection PubMed
description This review aims to examine the relationship of sodium and potassium intake and cardiovascular disease (CVD) among older people. Methods: We performed a literature search using PubMed and Web of Science (January 2015 to July 2020) without language restriction. Observational and experimental studies that reported the relationship between sodium, potassium, or sodium-to-potassium ratio with CVD among older adults aged higher than 60 years were included. The authors independently screened all identified studies, extracted information, and assessed the quality of included studies. Risk of bias was assessed using the Risk of Bias Assessment Tool for Nonrandomized Studies (RoBANS) for observational studies and the revised Cochrane risk-of-bias tool (RoB 2 tool) for randomized trials. Results: We included 12 studies (6 prospective cohort studies, 5 cross-sectional studies, and 1 experimental study). Five of the studies reported on sodium-to-potassium ratio (n = 5), and the others on potassium and/or sodium intake. Cardiovascular events (e.g., stroke and heart failure) were the most reported outcome (n = 9). Of the 12 studies included, five observational studies had low bias risk and the randomized controlled trial was judged as uncertain risk of bias. We found inconsistent results for the effect of the reduction of sodium intake in this population for lower risk of CVD. We found that both the increase of potassium intake and the decrease of sodium-to-potassium ratio were associated with lower risk of hypertension and CVD, particularly stroke. Conclusion: The present review suggests that both higher potassium and lower sodium-to-potassium ratio are associated with lower risk of CVD.
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spelling pubmed-76972112020-11-29 Sodium and Potassium Intake and Cardiovascular Disease in Older People: A Systematic Review Gonçalves, Carla Abreu, Sandra Nutrients Review This review aims to examine the relationship of sodium and potassium intake and cardiovascular disease (CVD) among older people. Methods: We performed a literature search using PubMed and Web of Science (January 2015 to July 2020) without language restriction. Observational and experimental studies that reported the relationship between sodium, potassium, or sodium-to-potassium ratio with CVD among older adults aged higher than 60 years were included. The authors independently screened all identified studies, extracted information, and assessed the quality of included studies. Risk of bias was assessed using the Risk of Bias Assessment Tool for Nonrandomized Studies (RoBANS) for observational studies and the revised Cochrane risk-of-bias tool (RoB 2 tool) for randomized trials. Results: We included 12 studies (6 prospective cohort studies, 5 cross-sectional studies, and 1 experimental study). Five of the studies reported on sodium-to-potassium ratio (n = 5), and the others on potassium and/or sodium intake. Cardiovascular events (e.g., stroke and heart failure) were the most reported outcome (n = 9). Of the 12 studies included, five observational studies had low bias risk and the randomized controlled trial was judged as uncertain risk of bias. We found inconsistent results for the effect of the reduction of sodium intake in this population for lower risk of CVD. We found that both the increase of potassium intake and the decrease of sodium-to-potassium ratio were associated with lower risk of hypertension and CVD, particularly stroke. Conclusion: The present review suggests that both higher potassium and lower sodium-to-potassium ratio are associated with lower risk of CVD. MDPI 2020-11-10 /pmc/articles/PMC7697211/ /pubmed/33182820 http://dx.doi.org/10.3390/nu12113447 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gonçalves, Carla
Abreu, Sandra
Sodium and Potassium Intake and Cardiovascular Disease in Older People: A Systematic Review
title Sodium and Potassium Intake and Cardiovascular Disease in Older People: A Systematic Review
title_full Sodium and Potassium Intake and Cardiovascular Disease in Older People: A Systematic Review
title_fullStr Sodium and Potassium Intake and Cardiovascular Disease in Older People: A Systematic Review
title_full_unstemmed Sodium and Potassium Intake and Cardiovascular Disease in Older People: A Systematic Review
title_short Sodium and Potassium Intake and Cardiovascular Disease in Older People: A Systematic Review
title_sort sodium and potassium intake and cardiovascular disease in older people: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697211/
https://www.ncbi.nlm.nih.gov/pubmed/33182820
http://dx.doi.org/10.3390/nu12113447
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