Long noncoding RNAs: functions and mechanisms in colon cancer

Evidence indicates that long non-coding RNAs (lncRNAs) play a crucial role in the carcinogenesis and progression of a wide variety of human malignancies including colon cancer. In this review, we describe the functions and mechanisms of lncRNAs involved in colon oncogenesis, such as HOTAIR, PVT1, H1...

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Autores principales: Chen, Sian, Shen, Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697375/
https://www.ncbi.nlm.nih.gov/pubmed/33246471
http://dx.doi.org/10.1186/s12943-020-01287-2
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author Chen, Sian
Shen, Xian
author_facet Chen, Sian
Shen, Xian
author_sort Chen, Sian
collection PubMed
description Evidence indicates that long non-coding RNAs (lncRNAs) play a crucial role in the carcinogenesis and progression of a wide variety of human malignancies including colon cancer. In this review, we describe the functions and mechanisms of lncRNAs involved in colon oncogenesis, such as HOTAIR, PVT1, H19, MALAT1, SNHG1, SNHG7, SNHG15, TUG1, XIST, ROR and ZEB1-AS1. We summarize the roles of lncRNAs in regulating cell proliferation, cell apoptotic death, the cell cycle, cell migrative and invasive ability, epithelial-mesenchymal transition (EMT), cancer stem cells and drug resistance in colon cancer. In addition, we briefly highlight the functions of circRNAs in colon tumorigenesis and progression, including circPPP1R12A, circPIP5K1A, circCTIC1, circ_0001313, circRNA_104916 and circRNA-ACAP2. This review provides the rationale for anticancer therapy via modulation of lncRNAs and circular RNAs (circRNAs) in colon carcinoma.
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spelling pubmed-76973752020-11-30 Long noncoding RNAs: functions and mechanisms in colon cancer Chen, Sian Shen, Xian Mol Cancer Review Evidence indicates that long non-coding RNAs (lncRNAs) play a crucial role in the carcinogenesis and progression of a wide variety of human malignancies including colon cancer. In this review, we describe the functions and mechanisms of lncRNAs involved in colon oncogenesis, such as HOTAIR, PVT1, H19, MALAT1, SNHG1, SNHG7, SNHG15, TUG1, XIST, ROR and ZEB1-AS1. We summarize the roles of lncRNAs in regulating cell proliferation, cell apoptotic death, the cell cycle, cell migrative and invasive ability, epithelial-mesenchymal transition (EMT), cancer stem cells and drug resistance in colon cancer. In addition, we briefly highlight the functions of circRNAs in colon tumorigenesis and progression, including circPPP1R12A, circPIP5K1A, circCTIC1, circ_0001313, circRNA_104916 and circRNA-ACAP2. This review provides the rationale for anticancer therapy via modulation of lncRNAs and circular RNAs (circRNAs) in colon carcinoma. BioMed Central 2020-11-28 /pmc/articles/PMC7697375/ /pubmed/33246471 http://dx.doi.org/10.1186/s12943-020-01287-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Chen, Sian
Shen, Xian
Long noncoding RNAs: functions and mechanisms in colon cancer
title Long noncoding RNAs: functions and mechanisms in colon cancer
title_full Long noncoding RNAs: functions and mechanisms in colon cancer
title_fullStr Long noncoding RNAs: functions and mechanisms in colon cancer
title_full_unstemmed Long noncoding RNAs: functions and mechanisms in colon cancer
title_short Long noncoding RNAs: functions and mechanisms in colon cancer
title_sort long noncoding rnas: functions and mechanisms in colon cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697375/
https://www.ncbi.nlm.nih.gov/pubmed/33246471
http://dx.doi.org/10.1186/s12943-020-01287-2
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