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Proteasome inhibitors reduce thrombospondin-1 release in human dysferlin-deficient myotubes
BACKGROUND: Dysferlinopathies are a group of muscle disorders causing muscle weakness and absence or low levels of dysferlin, a type-II transmembrane protein and the causative gene of these dystrophies. Dysferlin is implicated in vesicle fusion, trafficking, and membrane repair. Muscle biopsy of pat...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697384/ https://www.ncbi.nlm.nih.gov/pubmed/33246442 http://dx.doi.org/10.1186/s12891-020-03756-7 |