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Transformation and Cytotoxicity of Surface-Modified Silver Nanoparticles Undergoing Long-Term Aging

Silver nanoparticles (AgNPs) are constituents of many consumer products, but the future of their production depends on ensuring safety. The stability of AgNPs in various physiological solutions and aging in storage may affect the accuracy of predicted nanoparticle toxicity. The goal of this study wa...

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Autores principales: Pang, Chengfang, Zhang, Panhong, Mu, Yunsong, Ren, Jingzheng, Zhao, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697416/
https://www.ncbi.nlm.nih.gov/pubmed/33203023
http://dx.doi.org/10.3390/nano10112255
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author Pang, Chengfang
Zhang, Panhong
Mu, Yunsong
Ren, Jingzheng
Zhao, Bin
author_facet Pang, Chengfang
Zhang, Panhong
Mu, Yunsong
Ren, Jingzheng
Zhao, Bin
author_sort Pang, Chengfang
collection PubMed
description Silver nanoparticles (AgNPs) are constituents of many consumer products, but the future of their production depends on ensuring safety. The stability of AgNPs in various physiological solutions and aging in storage may affect the accuracy of predicted nanoparticle toxicity. The goal of this study was to simulate the transformation of AgNPs in different media representatives to the life cycle in the environment and to identify their toxicity to Hepa1c1c7 cells in a long-term aging process. AgNPs coated with citrate, polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), and branched polyethyleneimine (BPEI) were studied. Our results show that the exposure media had a significant impact on the transformation of AgNPs. Citrate-coated AgNPs showed significant aggregation in phosphate-buffered saline. The aging of AgNPs in optimal storage showed that the charge-stabilized particles (citrate) were more unstable, with significant aggregation and shape changes, than sterically stabilized particles (PEG AgNPs, PVP AgNPs). The BPEI AgNPs showed the highest dissolution of AgNPs, which induced significantly increased toxicity to Hepa1c1c7 cells. Overall, our findings showed that storage and media of AgNPs influenced the transformation of AgNPs and that the resulting changes in the AgNPs’ physicochemical properties influenced their toxicity. Our study contributes to the understanding of AgNPs’ transformations under realistic exposure scenarios and increasing the predictability of risk assessments.
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spelling pubmed-76974162020-11-29 Transformation and Cytotoxicity of Surface-Modified Silver Nanoparticles Undergoing Long-Term Aging Pang, Chengfang Zhang, Panhong Mu, Yunsong Ren, Jingzheng Zhao, Bin Nanomaterials (Basel) Article Silver nanoparticles (AgNPs) are constituents of many consumer products, but the future of their production depends on ensuring safety. The stability of AgNPs in various physiological solutions and aging in storage may affect the accuracy of predicted nanoparticle toxicity. The goal of this study was to simulate the transformation of AgNPs in different media representatives to the life cycle in the environment and to identify their toxicity to Hepa1c1c7 cells in a long-term aging process. AgNPs coated with citrate, polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), and branched polyethyleneimine (BPEI) were studied. Our results show that the exposure media had a significant impact on the transformation of AgNPs. Citrate-coated AgNPs showed significant aggregation in phosphate-buffered saline. The aging of AgNPs in optimal storage showed that the charge-stabilized particles (citrate) were more unstable, with significant aggregation and shape changes, than sterically stabilized particles (PEG AgNPs, PVP AgNPs). The BPEI AgNPs showed the highest dissolution of AgNPs, which induced significantly increased toxicity to Hepa1c1c7 cells. Overall, our findings showed that storage and media of AgNPs influenced the transformation of AgNPs and that the resulting changes in the AgNPs’ physicochemical properties influenced their toxicity. Our study contributes to the understanding of AgNPs’ transformations under realistic exposure scenarios and increasing the predictability of risk assessments. MDPI 2020-11-13 /pmc/articles/PMC7697416/ /pubmed/33203023 http://dx.doi.org/10.3390/nano10112255 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pang, Chengfang
Zhang, Panhong
Mu, Yunsong
Ren, Jingzheng
Zhao, Bin
Transformation and Cytotoxicity of Surface-Modified Silver Nanoparticles Undergoing Long-Term Aging
title Transformation and Cytotoxicity of Surface-Modified Silver Nanoparticles Undergoing Long-Term Aging
title_full Transformation and Cytotoxicity of Surface-Modified Silver Nanoparticles Undergoing Long-Term Aging
title_fullStr Transformation and Cytotoxicity of Surface-Modified Silver Nanoparticles Undergoing Long-Term Aging
title_full_unstemmed Transformation and Cytotoxicity of Surface-Modified Silver Nanoparticles Undergoing Long-Term Aging
title_short Transformation and Cytotoxicity of Surface-Modified Silver Nanoparticles Undergoing Long-Term Aging
title_sort transformation and cytotoxicity of surface-modified silver nanoparticles undergoing long-term aging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697416/
https://www.ncbi.nlm.nih.gov/pubmed/33203023
http://dx.doi.org/10.3390/nano10112255
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