Beyond LKB1 Mutations in Non-Small Cell Lung Cancer: Defining LKB1less Phenotype to Optimize Patient Selection and Treatment

LKB1 is frequently mutated in non-small cell lung cancer (NSCLC). LKB1-mutated NSCLCs often have a dismal prognosis and receive lower benefit from the currently available therapies. LKB1 acts as a cell emergency brake in low-energy conditions, by modulating the activity of crucial anabolic enzymes....

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Detalles Bibliográficos
Autores principales: Borzi, Cristina, Galli, Giulia, Ganzinelli, Monica, Signorelli, Diego, Vernieri, Claudio, Garassino, Marina Chiara, Sozzi, Gabriella, Moro, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697441/
https://www.ncbi.nlm.nih.gov/pubmed/33202760
http://dx.doi.org/10.3390/ph13110385

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