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Pathological and Pharmacological Roles of Mitochondrial Reactive Oxygen Species in Malignant Neoplasms: Therapies Involving Chemical Compounds, Natural Products, and Photosensitizers

Oxidative stress plays an important role in cellular processes. Consequently, oxidative stress also affects etiology, progression, and response to therapeutics in various pathological conditions including malignant tumors. Oxidative stress and associated outcomes are often brought about by excessive...

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Autores principales: Miyata, Yasuyoshi, Mukae, Yuta, Harada, Junki, Matsuda, Tsuyoshi, Mitsunari, Kensuke, Matsuo, Tomohiro, Ohba, Kojiro, Sakai, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697499/
https://www.ncbi.nlm.nih.gov/pubmed/33187225
http://dx.doi.org/10.3390/molecules25225252
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author Miyata, Yasuyoshi
Mukae, Yuta
Harada, Junki
Matsuda, Tsuyoshi
Mitsunari, Kensuke
Matsuo, Tomohiro
Ohba, Kojiro
Sakai, Hideki
author_facet Miyata, Yasuyoshi
Mukae, Yuta
Harada, Junki
Matsuda, Tsuyoshi
Mitsunari, Kensuke
Matsuo, Tomohiro
Ohba, Kojiro
Sakai, Hideki
author_sort Miyata, Yasuyoshi
collection PubMed
description Oxidative stress plays an important role in cellular processes. Consequently, oxidative stress also affects etiology, progression, and response to therapeutics in various pathological conditions including malignant tumors. Oxidative stress and associated outcomes are often brought about by excessive generation of reactive oxygen species (ROS). Accumulation of ROS occurs due to dysregulation of homeostasis in an otherwise strictly controlled physiological condition. In fact, intracellular ROS levels are closely associated with the pathological status and outcome of numerous diseases. Notably, mitochondria are recognized as the critical regulator and primary source of ROS. Damage to mitochondria increases mitochondrial ROS (mROS) production, which leads to an increased level of total intracellular ROS. However, intracellular ROS level may not always reflect mROS levels, as ROS is not only produced by mitochondria but also by other organelles such as endoplasmic reticulum and peroxisomes. Thus, an evaluation of mROS would help us to recognize the biological and pathological characteristics and predictive markers of malignant tumors and develop efficient treatment strategies. In this review, we describe the pathological significance of mROS in malignant neoplasms. In particular, we show the association of mROS-related signaling in the molecular mechanisms of chemically synthesized and natural chemotherapeutic agents and photodynamic therapy.
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spelling pubmed-76974992020-11-29 Pathological and Pharmacological Roles of Mitochondrial Reactive Oxygen Species in Malignant Neoplasms: Therapies Involving Chemical Compounds, Natural Products, and Photosensitizers Miyata, Yasuyoshi Mukae, Yuta Harada, Junki Matsuda, Tsuyoshi Mitsunari, Kensuke Matsuo, Tomohiro Ohba, Kojiro Sakai, Hideki Molecules Review Oxidative stress plays an important role in cellular processes. Consequently, oxidative stress also affects etiology, progression, and response to therapeutics in various pathological conditions including malignant tumors. Oxidative stress and associated outcomes are often brought about by excessive generation of reactive oxygen species (ROS). Accumulation of ROS occurs due to dysregulation of homeostasis in an otherwise strictly controlled physiological condition. In fact, intracellular ROS levels are closely associated with the pathological status and outcome of numerous diseases. Notably, mitochondria are recognized as the critical regulator and primary source of ROS. Damage to mitochondria increases mitochondrial ROS (mROS) production, which leads to an increased level of total intracellular ROS. However, intracellular ROS level may not always reflect mROS levels, as ROS is not only produced by mitochondria but also by other organelles such as endoplasmic reticulum and peroxisomes. Thus, an evaluation of mROS would help us to recognize the biological and pathological characteristics and predictive markers of malignant tumors and develop efficient treatment strategies. In this review, we describe the pathological significance of mROS in malignant neoplasms. In particular, we show the association of mROS-related signaling in the molecular mechanisms of chemically synthesized and natural chemotherapeutic agents and photodynamic therapy. MDPI 2020-11-11 /pmc/articles/PMC7697499/ /pubmed/33187225 http://dx.doi.org/10.3390/molecules25225252 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Miyata, Yasuyoshi
Mukae, Yuta
Harada, Junki
Matsuda, Tsuyoshi
Mitsunari, Kensuke
Matsuo, Tomohiro
Ohba, Kojiro
Sakai, Hideki
Pathological and Pharmacological Roles of Mitochondrial Reactive Oxygen Species in Malignant Neoplasms: Therapies Involving Chemical Compounds, Natural Products, and Photosensitizers
title Pathological and Pharmacological Roles of Mitochondrial Reactive Oxygen Species in Malignant Neoplasms: Therapies Involving Chemical Compounds, Natural Products, and Photosensitizers
title_full Pathological and Pharmacological Roles of Mitochondrial Reactive Oxygen Species in Malignant Neoplasms: Therapies Involving Chemical Compounds, Natural Products, and Photosensitizers
title_fullStr Pathological and Pharmacological Roles of Mitochondrial Reactive Oxygen Species in Malignant Neoplasms: Therapies Involving Chemical Compounds, Natural Products, and Photosensitizers
title_full_unstemmed Pathological and Pharmacological Roles of Mitochondrial Reactive Oxygen Species in Malignant Neoplasms: Therapies Involving Chemical Compounds, Natural Products, and Photosensitizers
title_short Pathological and Pharmacological Roles of Mitochondrial Reactive Oxygen Species in Malignant Neoplasms: Therapies Involving Chemical Compounds, Natural Products, and Photosensitizers
title_sort pathological and pharmacological roles of mitochondrial reactive oxygen species in malignant neoplasms: therapies involving chemical compounds, natural products, and photosensitizers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697499/
https://www.ncbi.nlm.nih.gov/pubmed/33187225
http://dx.doi.org/10.3390/molecules25225252
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