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Balloon Pulmonary Angioplasty in Patients with Chronic Thromboembolic Pulmonary Hypertension: Impact on Clinical and Hemodynamic Parameters, Quality of Life and Risk Profile

Balloon pulmonary angioplasty (BPA) is a novel treatment option for patients with chronic thromboembolic pulmonary hypertension (CTEPH) who are not eligible for pulmonary endarterectomy (PEA) or suffer from persistent pulmonary hypertension after PEA. The aim of this study was to evaluate the real-l...

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Autores principales: Jansa, Pavel, Heller, Samuel, Svoboda, Michal, Pad’our, Michal, Ambrož, David, Dytrych, Vladimír, Širanec, Michal, Kovárník, Tomáš, Felšőci, Marián, Hutyra, Martin, Linhart, Aleš, Lindner, Jaroslav, Aschermann, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697583/
https://www.ncbi.nlm.nih.gov/pubmed/33182415
http://dx.doi.org/10.3390/jcm9113608
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author Jansa, Pavel
Heller, Samuel
Svoboda, Michal
Pad’our, Michal
Ambrož, David
Dytrych, Vladimír
Širanec, Michal
Kovárník, Tomáš
Felšőci, Marián
Hutyra, Martin
Linhart, Aleš
Lindner, Jaroslav
Aschermann, Michael
author_facet Jansa, Pavel
Heller, Samuel
Svoboda, Michal
Pad’our, Michal
Ambrož, David
Dytrych, Vladimír
Širanec, Michal
Kovárník, Tomáš
Felšőci, Marián
Hutyra, Martin
Linhart, Aleš
Lindner, Jaroslav
Aschermann, Michael
author_sort Jansa, Pavel
collection PubMed
description Balloon pulmonary angioplasty (BPA) is a novel treatment option for patients with chronic thromboembolic pulmonary hypertension (CTEPH) who are not eligible for pulmonary endarterectomy (PEA) or suffer from persistent pulmonary hypertension after PEA. The aim of this study was to evaluate the real-life efficacy and safety of BPA in a consecutive group of patients who were diagnosed and treated in the national referral center for CTEPH in the Czech Republic. Here we report data from 160 BPA procedures performed in 64 patients. Efficacy analysis was performed in the subgroup of 25 patients who completed BPA series. Significant improvements were observed in New York Heart Association functional class (4% to 79% in I/II, p < 0.001), 6 min walking test distance (+54.3 m, p < 0.001), risk profile (15.8% to 68.5% with presence of 2/3 low risk criteria, p < 0.001), pulmonary artery mean pressure (−18%, p < 0.001), pulmonary vascular resistance (−32%, p < 0.001), stroke volume (+17%, p = 0.011) and quality of life (+37% in assessment of overall health status by a patient, p < 0.001). We observed 1 fatal periprocedural complication (1.6% of all 64 patients) and 19 BPA-related non-fatal complications (11.9% of all 160 interventions) that predominantly included hemoptysis (10.0% of all sessions). Overall survival at 12 months was 94.6%.
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spelling pubmed-76975832020-11-29 Balloon Pulmonary Angioplasty in Patients with Chronic Thromboembolic Pulmonary Hypertension: Impact on Clinical and Hemodynamic Parameters, Quality of Life and Risk Profile Jansa, Pavel Heller, Samuel Svoboda, Michal Pad’our, Michal Ambrož, David Dytrych, Vladimír Širanec, Michal Kovárník, Tomáš Felšőci, Marián Hutyra, Martin Linhart, Aleš Lindner, Jaroslav Aschermann, Michael J Clin Med Article Balloon pulmonary angioplasty (BPA) is a novel treatment option for patients with chronic thromboembolic pulmonary hypertension (CTEPH) who are not eligible for pulmonary endarterectomy (PEA) or suffer from persistent pulmonary hypertension after PEA. The aim of this study was to evaluate the real-life efficacy and safety of BPA in a consecutive group of patients who were diagnosed and treated in the national referral center for CTEPH in the Czech Republic. Here we report data from 160 BPA procedures performed in 64 patients. Efficacy analysis was performed in the subgroup of 25 patients who completed BPA series. Significant improvements were observed in New York Heart Association functional class (4% to 79% in I/II, p < 0.001), 6 min walking test distance (+54.3 m, p < 0.001), risk profile (15.8% to 68.5% with presence of 2/3 low risk criteria, p < 0.001), pulmonary artery mean pressure (−18%, p < 0.001), pulmonary vascular resistance (−32%, p < 0.001), stroke volume (+17%, p = 0.011) and quality of life (+37% in assessment of overall health status by a patient, p < 0.001). We observed 1 fatal periprocedural complication (1.6% of all 64 patients) and 19 BPA-related non-fatal complications (11.9% of all 160 interventions) that predominantly included hemoptysis (10.0% of all sessions). Overall survival at 12 months was 94.6%. MDPI 2020-11-09 /pmc/articles/PMC7697583/ /pubmed/33182415 http://dx.doi.org/10.3390/jcm9113608 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jansa, Pavel
Heller, Samuel
Svoboda, Michal
Pad’our, Michal
Ambrož, David
Dytrych, Vladimír
Širanec, Michal
Kovárník, Tomáš
Felšőci, Marián
Hutyra, Martin
Linhart, Aleš
Lindner, Jaroslav
Aschermann, Michael
Balloon Pulmonary Angioplasty in Patients with Chronic Thromboembolic Pulmonary Hypertension: Impact on Clinical and Hemodynamic Parameters, Quality of Life and Risk Profile
title Balloon Pulmonary Angioplasty in Patients with Chronic Thromboembolic Pulmonary Hypertension: Impact on Clinical and Hemodynamic Parameters, Quality of Life and Risk Profile
title_full Balloon Pulmonary Angioplasty in Patients with Chronic Thromboembolic Pulmonary Hypertension: Impact on Clinical and Hemodynamic Parameters, Quality of Life and Risk Profile
title_fullStr Balloon Pulmonary Angioplasty in Patients with Chronic Thromboembolic Pulmonary Hypertension: Impact on Clinical and Hemodynamic Parameters, Quality of Life and Risk Profile
title_full_unstemmed Balloon Pulmonary Angioplasty in Patients with Chronic Thromboembolic Pulmonary Hypertension: Impact on Clinical and Hemodynamic Parameters, Quality of Life and Risk Profile
title_short Balloon Pulmonary Angioplasty in Patients with Chronic Thromboembolic Pulmonary Hypertension: Impact on Clinical and Hemodynamic Parameters, Quality of Life and Risk Profile
title_sort balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension: impact on clinical and hemodynamic parameters, quality of life and risk profile
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697583/
https://www.ncbi.nlm.nih.gov/pubmed/33182415
http://dx.doi.org/10.3390/jcm9113608
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