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Genomic Analysis of Oral Lichen Planus and Related Oral Microbiome Pathogens
Oral lichen planus (OLP) is a common chronic inflammatory disease affecting the oral mucosa. The pathogenesis of OLP is incompletely understood but is thought to be related to the immune system. As the oral cavity is a major reservoir and transmission gateway for bacteria, viruses, and fungi, the mi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697643/ https://www.ncbi.nlm.nih.gov/pubmed/33207582 http://dx.doi.org/10.3390/pathogens9110952 |
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author | Zhong, Evelyn F. Chang, Andrea Stucky, Andres Chen, Xuelian Mundluru, Tarun Khalifeh, Mohammad Sedghizadeh, Parish P. |
author_facet | Zhong, Evelyn F. Chang, Andrea Stucky, Andres Chen, Xuelian Mundluru, Tarun Khalifeh, Mohammad Sedghizadeh, Parish P. |
author_sort | Zhong, Evelyn F. |
collection | PubMed |
description | Oral lichen planus (OLP) is a common chronic inflammatory disease affecting the oral mucosa. The pathogenesis of OLP is incompletely understood but is thought to be related to the immune system. As the oral cavity is a major reservoir and transmission gateway for bacteria, viruses, and fungi, the microbial composition of the oral cavity could play a role in the pathogenesis of OLP. However, limited by analytic technology and knowledge of the microbial community in the oral cavity, it is not yet clear which pathogens are associated with OLP. Next generation sequencing (NGS) is a powerful tool to identify pathogens for many infectious diseases. In this study, we compared the host cell gene expression profiles and the microbial profiles between OLP patients and matched healthy individuals. We identified the activation of the hepatocyte nuclear factor alpha (HNF4A) network in OLP patients and potential pathogens, including Corynebacterium matruchotii, Fusobacterium periodonticum, Streptococcus intermedius, Streptococcus oralis, and Prevotella denticola. Prevotella denticola is capable of activating the HNF4A gene network. Our findings shed light on the previously elusive association of OLP with various diseases like hepatitis, and indicate that OLP is a T-helper type 17 (Th17) mediated mucosal inflammatory process. The identified molecular pathways and microbes could be used to inform future investigations into OLP pathogenesis and to develop novel therapeutics for OLP treatment. |
format | Online Article Text |
id | pubmed-7697643 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76976432020-11-29 Genomic Analysis of Oral Lichen Planus and Related Oral Microbiome Pathogens Zhong, Evelyn F. Chang, Andrea Stucky, Andres Chen, Xuelian Mundluru, Tarun Khalifeh, Mohammad Sedghizadeh, Parish P. Pathogens Article Oral lichen planus (OLP) is a common chronic inflammatory disease affecting the oral mucosa. The pathogenesis of OLP is incompletely understood but is thought to be related to the immune system. As the oral cavity is a major reservoir and transmission gateway for bacteria, viruses, and fungi, the microbial composition of the oral cavity could play a role in the pathogenesis of OLP. However, limited by analytic technology and knowledge of the microbial community in the oral cavity, it is not yet clear which pathogens are associated with OLP. Next generation sequencing (NGS) is a powerful tool to identify pathogens for many infectious diseases. In this study, we compared the host cell gene expression profiles and the microbial profiles between OLP patients and matched healthy individuals. We identified the activation of the hepatocyte nuclear factor alpha (HNF4A) network in OLP patients and potential pathogens, including Corynebacterium matruchotii, Fusobacterium periodonticum, Streptococcus intermedius, Streptococcus oralis, and Prevotella denticola. Prevotella denticola is capable of activating the HNF4A gene network. Our findings shed light on the previously elusive association of OLP with various diseases like hepatitis, and indicate that OLP is a T-helper type 17 (Th17) mediated mucosal inflammatory process. The identified molecular pathways and microbes could be used to inform future investigations into OLP pathogenesis and to develop novel therapeutics for OLP treatment. MDPI 2020-11-16 /pmc/articles/PMC7697643/ /pubmed/33207582 http://dx.doi.org/10.3390/pathogens9110952 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhong, Evelyn F. Chang, Andrea Stucky, Andres Chen, Xuelian Mundluru, Tarun Khalifeh, Mohammad Sedghizadeh, Parish P. Genomic Analysis of Oral Lichen Planus and Related Oral Microbiome Pathogens |
title | Genomic Analysis of Oral Lichen Planus and Related Oral Microbiome Pathogens |
title_full | Genomic Analysis of Oral Lichen Planus and Related Oral Microbiome Pathogens |
title_fullStr | Genomic Analysis of Oral Lichen Planus and Related Oral Microbiome Pathogens |
title_full_unstemmed | Genomic Analysis of Oral Lichen Planus and Related Oral Microbiome Pathogens |
title_short | Genomic Analysis of Oral Lichen Planus and Related Oral Microbiome Pathogens |
title_sort | genomic analysis of oral lichen planus and related oral microbiome pathogens |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697643/ https://www.ncbi.nlm.nih.gov/pubmed/33207582 http://dx.doi.org/10.3390/pathogens9110952 |
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