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Synthesis of Nylon 6/Modified Carbon Black Nanocomposites for Application in Uric Acid Adsorption

High uric acid levels cause different clinic conditions. One of them is hyperuricemia, which leads to kidney damage. A solution for eliminating uric acid in the blood is by hemodialysis, which is performed using nanocomposite membranes. In this work, Nylon 6 nanocomposites were synthesized with modi...

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Autores principales: Andrade-Guel, Marlene, Ávila-Orta, Carlos A., Cadenas-Pliego, Gregorio, Cabello-Alvarado, Christian J., Pérez-Alvarez, Marissa, Reyes-Rodríguez, Pamela, Inam, Fawad, Cortés-Hernández, Dora A., Quiñones-Jurado, Zoe V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697714/
https://www.ncbi.nlm.nih.gov/pubmed/33212761
http://dx.doi.org/10.3390/ma13225173
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author Andrade-Guel, Marlene
Ávila-Orta, Carlos A.
Cadenas-Pliego, Gregorio
Cabello-Alvarado, Christian J.
Pérez-Alvarez, Marissa
Reyes-Rodríguez, Pamela
Inam, Fawad
Cortés-Hernández, Dora A.
Quiñones-Jurado, Zoe V.
author_facet Andrade-Guel, Marlene
Ávila-Orta, Carlos A.
Cadenas-Pliego, Gregorio
Cabello-Alvarado, Christian J.
Pérez-Alvarez, Marissa
Reyes-Rodríguez, Pamela
Inam, Fawad
Cortés-Hernández, Dora A.
Quiñones-Jurado, Zoe V.
author_sort Andrade-Guel, Marlene
collection PubMed
description High uric acid levels cause different clinic conditions. One of them is hyperuricemia, which leads to kidney damage. A solution for eliminating uric acid in the blood is by hemodialysis, which is performed using nanocomposite membranes. In this work, Nylon 6 nanocomposites were synthesized with modified carbon black (MCB), which were considered candidate materials for hemodialysis membranes. The modification of carbon black was made with citric acid using the variable-frequency ultrasound method. The new MCB was characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), X-ray diffraction (XRD), transmission electron microscopy (TEM), and dispersion tests. Nylon 6/MCB nanocomposites were processed using the ultrasound-assisted melt-extrusion method to improve the dispersion procedure of the nanoparticles. The Nylon 6/MCB nanocomposites were characterized by FTIR, TGA, and differential scanning calorimetry (DSC). These were assessed for the absorption of toxins and hemocompatibility. MBC and nanocomposites showed excellent uric acid removal (78–82%) and hemocompatibility (1.6–1.8%). These results suggest that Nylon 6/MCB nanocomposites with low loading percentages can be used on a large scale without compatibility problems with blood.
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spelling pubmed-76977142020-11-29 Synthesis of Nylon 6/Modified Carbon Black Nanocomposites for Application in Uric Acid Adsorption Andrade-Guel, Marlene Ávila-Orta, Carlos A. Cadenas-Pliego, Gregorio Cabello-Alvarado, Christian J. Pérez-Alvarez, Marissa Reyes-Rodríguez, Pamela Inam, Fawad Cortés-Hernández, Dora A. Quiñones-Jurado, Zoe V. Materials (Basel) Article High uric acid levels cause different clinic conditions. One of them is hyperuricemia, which leads to kidney damage. A solution for eliminating uric acid in the blood is by hemodialysis, which is performed using nanocomposite membranes. In this work, Nylon 6 nanocomposites were synthesized with modified carbon black (MCB), which were considered candidate materials for hemodialysis membranes. The modification of carbon black was made with citric acid using the variable-frequency ultrasound method. The new MCB was characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), X-ray diffraction (XRD), transmission electron microscopy (TEM), and dispersion tests. Nylon 6/MCB nanocomposites were processed using the ultrasound-assisted melt-extrusion method to improve the dispersion procedure of the nanoparticles. The Nylon 6/MCB nanocomposites were characterized by FTIR, TGA, and differential scanning calorimetry (DSC). These were assessed for the absorption of toxins and hemocompatibility. MBC and nanocomposites showed excellent uric acid removal (78–82%) and hemocompatibility (1.6–1.8%). These results suggest that Nylon 6/MCB nanocomposites with low loading percentages can be used on a large scale without compatibility problems with blood. MDPI 2020-11-17 /pmc/articles/PMC7697714/ /pubmed/33212761 http://dx.doi.org/10.3390/ma13225173 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Andrade-Guel, Marlene
Ávila-Orta, Carlos A.
Cadenas-Pliego, Gregorio
Cabello-Alvarado, Christian J.
Pérez-Alvarez, Marissa
Reyes-Rodríguez, Pamela
Inam, Fawad
Cortés-Hernández, Dora A.
Quiñones-Jurado, Zoe V.
Synthesis of Nylon 6/Modified Carbon Black Nanocomposites for Application in Uric Acid Adsorption
title Synthesis of Nylon 6/Modified Carbon Black Nanocomposites for Application in Uric Acid Adsorption
title_full Synthesis of Nylon 6/Modified Carbon Black Nanocomposites for Application in Uric Acid Adsorption
title_fullStr Synthesis of Nylon 6/Modified Carbon Black Nanocomposites for Application in Uric Acid Adsorption
title_full_unstemmed Synthesis of Nylon 6/Modified Carbon Black Nanocomposites for Application in Uric Acid Adsorption
title_short Synthesis of Nylon 6/Modified Carbon Black Nanocomposites for Application in Uric Acid Adsorption
title_sort synthesis of nylon 6/modified carbon black nanocomposites for application in uric acid adsorption
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697714/
https://www.ncbi.nlm.nih.gov/pubmed/33212761
http://dx.doi.org/10.3390/ma13225173
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