Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms

The retinoid X receptor (RXR) is a ligand-sensing transcription factor acting mainly as a universal heterodimer partner for other nuclear receptors. Despite presenting as a potential therapeutic target for cancer and neurodegeneration, adverse effects typically observed for RXR agonists, likely due...

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Detalles Bibliográficos
Autores principales: Chaikuad, Apirat, Pollinger, Julius, Rühl, Michael, Ni, Xiaomin, Kilu, Whitney, Heering, Jan, Merk, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697888/
https://www.ncbi.nlm.nih.gov/pubmed/33187070
http://dx.doi.org/10.3390/ijms21228457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697888/
https://www.ncbi.nlm.nih.gov/pubmed/33187070
http://dx.doi.org/10.3390/ijms21228457

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