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Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms
The retinoid X receptor (RXR) is a ligand-sensing transcription factor acting mainly as a universal heterodimer partner for other nuclear receptors. Despite presenting as a potential therapeutic target for cancer and neurodegeneration, adverse effects typically observed for RXR agonists, likely due...
Autores principales: | Chaikuad, Apirat, Pollinger, Julius, Rühl, Michael, Ni, Xiaomin, Kilu, Whitney, Heering, Jan, Merk, Daniel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697888/ https://www.ncbi.nlm.nih.gov/pubmed/33187070 http://dx.doi.org/10.3390/ijms21228457 |
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