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Role of Adiponectin and Tumor Necrosis Factor-Alpha in the Pathogenesis and Evolution of Type 1 Diabetes Mellitus in Children and Adolescents

Type 1 diabetes mellitus (T1DM) is a complex condition caused by the destruction of pancreatic beta cells by autoimmune mechanisms. As a result, insulin deficiency and subsequent hyperglycemia occur. The aim of the present study is to investigate the role of adiponectin and tumor necrosis factor alp...

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Autores principales: Szabo, Csilla Enikő, Man, Oana Iulia, Istrate, Alexandru, Kiss, Eva, Catana, Andreea, Creț, Victoria, Șerban, Radu Sorin, Pop, Ioan Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697906/
https://www.ncbi.nlm.nih.gov/pubmed/33202729
http://dx.doi.org/10.3390/diagnostics10110945
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author Szabo, Csilla Enikő
Man, Oana Iulia
Istrate, Alexandru
Kiss, Eva
Catana, Andreea
Creț, Victoria
Șerban, Radu Sorin
Pop, Ioan Victor
author_facet Szabo, Csilla Enikő
Man, Oana Iulia
Istrate, Alexandru
Kiss, Eva
Catana, Andreea
Creț, Victoria
Șerban, Radu Sorin
Pop, Ioan Victor
author_sort Szabo, Csilla Enikő
collection PubMed
description Type 1 diabetes mellitus (T1DM) is a complex condition caused by the destruction of pancreatic beta cells by autoimmune mechanisms. As a result, insulin deficiency and subsequent hyperglycemia occur. The aim of the present study is to investigate the role of adiponectin and tumor necrosis factor alpha (TNF-α) in the development of T1DM. The study is designed as an observational case-control study, involving 52 diabetic patients and 66 controls. Z scores for Body Mass Index (BMI), weight, height, and adiponectin and TNF-α serum levels were assessed in both groups. The T1DM group had significantly higher TNF-α levels and a significantly higher proportion of high-risk patients for inflammation based on TNF-α values as compared to the control group, while both groups had statistically similar adiponectin levels and a similar proportion of high/medium-risk patients based on adiponectin values. TNF-α plays a significant role in the pathogenesis and evolution of T1DM and it may represent an additional marker of disease progression, as well as a potential target of immunotherapeutic strategies. In the present study, no statistically significant differences were recorded in adiponectin levels neither in diabetic patients and controls, nor in high/medium severity risk diabetic patients.
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spelling pubmed-76979062020-11-29 Role of Adiponectin and Tumor Necrosis Factor-Alpha in the Pathogenesis and Evolution of Type 1 Diabetes Mellitus in Children and Adolescents Szabo, Csilla Enikő Man, Oana Iulia Istrate, Alexandru Kiss, Eva Catana, Andreea Creț, Victoria Șerban, Radu Sorin Pop, Ioan Victor Diagnostics (Basel) Article Type 1 diabetes mellitus (T1DM) is a complex condition caused by the destruction of pancreatic beta cells by autoimmune mechanisms. As a result, insulin deficiency and subsequent hyperglycemia occur. The aim of the present study is to investigate the role of adiponectin and tumor necrosis factor alpha (TNF-α) in the development of T1DM. The study is designed as an observational case-control study, involving 52 diabetic patients and 66 controls. Z scores for Body Mass Index (BMI), weight, height, and adiponectin and TNF-α serum levels were assessed in both groups. The T1DM group had significantly higher TNF-α levels and a significantly higher proportion of high-risk patients for inflammation based on TNF-α values as compared to the control group, while both groups had statistically similar adiponectin levels and a similar proportion of high/medium-risk patients based on adiponectin values. TNF-α plays a significant role in the pathogenesis and evolution of T1DM and it may represent an additional marker of disease progression, as well as a potential target of immunotherapeutic strategies. In the present study, no statistically significant differences were recorded in adiponectin levels neither in diabetic patients and controls, nor in high/medium severity risk diabetic patients. MDPI 2020-11-13 /pmc/articles/PMC7697906/ /pubmed/33202729 http://dx.doi.org/10.3390/diagnostics10110945 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Szabo, Csilla Enikő
Man, Oana Iulia
Istrate, Alexandru
Kiss, Eva
Catana, Andreea
Creț, Victoria
Șerban, Radu Sorin
Pop, Ioan Victor
Role of Adiponectin and Tumor Necrosis Factor-Alpha in the Pathogenesis and Evolution of Type 1 Diabetes Mellitus in Children and Adolescents
title Role of Adiponectin and Tumor Necrosis Factor-Alpha in the Pathogenesis and Evolution of Type 1 Diabetes Mellitus in Children and Adolescents
title_full Role of Adiponectin and Tumor Necrosis Factor-Alpha in the Pathogenesis and Evolution of Type 1 Diabetes Mellitus in Children and Adolescents
title_fullStr Role of Adiponectin and Tumor Necrosis Factor-Alpha in the Pathogenesis and Evolution of Type 1 Diabetes Mellitus in Children and Adolescents
title_full_unstemmed Role of Adiponectin and Tumor Necrosis Factor-Alpha in the Pathogenesis and Evolution of Type 1 Diabetes Mellitus in Children and Adolescents
title_short Role of Adiponectin and Tumor Necrosis Factor-Alpha in the Pathogenesis and Evolution of Type 1 Diabetes Mellitus in Children and Adolescents
title_sort role of adiponectin and tumor necrosis factor-alpha in the pathogenesis and evolution of type 1 diabetes mellitus in children and adolescents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697906/
https://www.ncbi.nlm.nih.gov/pubmed/33202729
http://dx.doi.org/10.3390/diagnostics10110945
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