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Translational Read-Through Therapy of RPGR Nonsense Mutations

X-chromosomal retinitis pigmentosa (RP) frequently is caused by mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene. We evaluated the potential of PTC124 (Ataluren, Translama(TM)) treatment to promote ribosomal read-through of premature termination codons (PTC) in RPGR. Expression con...

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Detalles Bibliográficos
Autores principales:	Vössing, Christine, Owczarek-Lipska, Marta, Nagel-Wolfrum, Kerstin, Reiff, Charlotte, Jüschke, Christoph, Neidhardt, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697989/ https://www.ncbi.nlm.nih.gov/pubmed/33182541 http://dx.doi.org/10.3390/ijms21228418

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