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Synthesis of Kisspeptin-Mimicking Fragments and Investigation of their Skin Anti-Aging Effects
In recent years, a number of active materials have been developed to provide anti-aging benefits for skin and, among them, peptides have been considered the most promising candidate due to their remarkable and long-lasting anti-wrinkle activity. Recent studies have begun to elucidate the relationshi...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698007/ https://www.ncbi.nlm.nih.gov/pubmed/33182726 http://dx.doi.org/10.3390/ijms21228439 |
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author | Lee, Kyung-Eun Jeong, Sugyeong Yun, Seok Kyun Kyung, Seoyeon Sophie, Abadie Moh, Sang Hyun Seo, Hyo Hyun Park, Myeong Sam Kang, Seunghyun Yeo, Hyeonju |
author_facet | Lee, Kyung-Eun Jeong, Sugyeong Yun, Seok Kyun Kyung, Seoyeon Sophie, Abadie Moh, Sang Hyun Seo, Hyo Hyun Park, Myeong Sam Kang, Seunghyun Yeo, Hyeonju |
author_sort | Lee, Kyung-Eun |
collection | PubMed |
description | In recent years, a number of active materials have been developed to provide anti-aging benefits for skin and, among them, peptides have been considered the most promising candidate due to their remarkable and long-lasting anti-wrinkle activity. Recent studies have begun to elucidate the relationship between the secretion of emotion-related hormones and skin aging. Kisspeptin, a neuropeptide encoded by the KISS1 gene, has gained attention in reproductive endocrinology since it stimulates the reproductive axis in the hypothalamus; however, the effects of Kisspeptin on skin have not been studied yet. In this study, we synthesized Kisspeptin-10 and Kisspeptin-E, which are biologically active fragments, to mimic the action of Kisspeptin. Next, we demonstrated the anti-aging effects of the Kisspeptin-mimicking fragments using UV-induced skin aging models, such as UV-induced human dermal fibroblasts (Hs68) and human skin explants. Kisspeptin-E suppressed UV-induced 11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) stimulation leading to a regulation of skin aging related genes, including type I procollagen, matrix metalloproteinases-1 (MMP-1), interleukin-6 (IL-6), and IL-8, and rescued the skin integrity. Taken together, these results suggest that Kisspeptin-E could be useful to improve UV-induced skin aging by modulating expression of stress related genes, such as 11β-HSD1. |
format | Online Article Text |
id | pubmed-7698007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76980072020-11-29 Synthesis of Kisspeptin-Mimicking Fragments and Investigation of their Skin Anti-Aging Effects Lee, Kyung-Eun Jeong, Sugyeong Yun, Seok Kyun Kyung, Seoyeon Sophie, Abadie Moh, Sang Hyun Seo, Hyo Hyun Park, Myeong Sam Kang, Seunghyun Yeo, Hyeonju Int J Mol Sci Article In recent years, a number of active materials have been developed to provide anti-aging benefits for skin and, among them, peptides have been considered the most promising candidate due to their remarkable and long-lasting anti-wrinkle activity. Recent studies have begun to elucidate the relationship between the secretion of emotion-related hormones and skin aging. Kisspeptin, a neuropeptide encoded by the KISS1 gene, has gained attention in reproductive endocrinology since it stimulates the reproductive axis in the hypothalamus; however, the effects of Kisspeptin on skin have not been studied yet. In this study, we synthesized Kisspeptin-10 and Kisspeptin-E, which are biologically active fragments, to mimic the action of Kisspeptin. Next, we demonstrated the anti-aging effects of the Kisspeptin-mimicking fragments using UV-induced skin aging models, such as UV-induced human dermal fibroblasts (Hs68) and human skin explants. Kisspeptin-E suppressed UV-induced 11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) stimulation leading to a regulation of skin aging related genes, including type I procollagen, matrix metalloproteinases-1 (MMP-1), interleukin-6 (IL-6), and IL-8, and rescued the skin integrity. Taken together, these results suggest that Kisspeptin-E could be useful to improve UV-induced skin aging by modulating expression of stress related genes, such as 11β-HSD1. MDPI 2020-11-10 /pmc/articles/PMC7698007/ /pubmed/33182726 http://dx.doi.org/10.3390/ijms21228439 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Kyung-Eun Jeong, Sugyeong Yun, Seok Kyun Kyung, Seoyeon Sophie, Abadie Moh, Sang Hyun Seo, Hyo Hyun Park, Myeong Sam Kang, Seunghyun Yeo, Hyeonju Synthesis of Kisspeptin-Mimicking Fragments and Investigation of their Skin Anti-Aging Effects |
title | Synthesis of Kisspeptin-Mimicking Fragments and Investigation of their Skin Anti-Aging Effects |
title_full | Synthesis of Kisspeptin-Mimicking Fragments and Investigation of their Skin Anti-Aging Effects |
title_fullStr | Synthesis of Kisspeptin-Mimicking Fragments and Investigation of their Skin Anti-Aging Effects |
title_full_unstemmed | Synthesis of Kisspeptin-Mimicking Fragments and Investigation of their Skin Anti-Aging Effects |
title_short | Synthesis of Kisspeptin-Mimicking Fragments and Investigation of their Skin Anti-Aging Effects |
title_sort | synthesis of kisspeptin-mimicking fragments and investigation of their skin anti-aging effects |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698007/ https://www.ncbi.nlm.nih.gov/pubmed/33182726 http://dx.doi.org/10.3390/ijms21228439 |
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