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Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis

This systematic review and meta-analysis sought to gain further insight into the relationship between cortisol reactivity and chronic widespread pain in patients with fibromyalgia. The studies selected were those conducted in adults with fibromyalgia that were random controlled, non-controlled or ob...

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Autores principales: Úbeda-D’Ocasar, Edurne, Jiménez Díaz-Benito, Victor, Gallego-Sendarrubias, Gracia María, Valera-Calero, Juan Antonio, Vicario-Merino, Ángel, Hervás-Pérez, Juan Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698032/
https://www.ncbi.nlm.nih.gov/pubmed/33182522
http://dx.doi.org/10.3390/diagnostics10110922
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author Úbeda-D’Ocasar, Edurne
Jiménez Díaz-Benito, Victor
Gallego-Sendarrubias, Gracia María
Valera-Calero, Juan Antonio
Vicario-Merino, Ángel
Hervás-Pérez, Juan Pablo
author_facet Úbeda-D’Ocasar, Edurne
Jiménez Díaz-Benito, Victor
Gallego-Sendarrubias, Gracia María
Valera-Calero, Juan Antonio
Vicario-Merino, Ángel
Hervás-Pérez, Juan Pablo
author_sort Úbeda-D’Ocasar, Edurne
collection PubMed
description This systematic review and meta-analysis sought to gain further insight into the relationship between cortisol reactivity and chronic widespread pain in patients with fibromyalgia. The studies selected were those conducted in adults with fibromyalgia that were random controlled, non-controlled or observational. Studies were excluded if they examined diseases other than fibromyalgia or if they did not report on pain or cortisol. Twelve studies met inclusion criteria. Data were extracted into tabular format using predefined data fields by two reviewers and assessed for accuracy by a third reviewer. The methodological quality of the studies was assessed using the PEDro scale. Data Synthesis: Of 263 studies identified, 12 were selected for our review and 10 were finally included as their methodological quality was good. In the meta-analysis, we calculated effect sizes of interventions on pain indicators and cortisol levels in patients with fibromyalgia. A small overall effect of all the interventions was observed on pain tolerance and pressure pain thresholds, yet this effect lacked significance (ES = 0.150; 95%CI 0.932–1.550; p > 0.05). Conclusions: While some effects of individual nonpharmacological therapeutic interventions were observed on both cortisol levels and measures of pain, our results suggest much further work is needed to elucidate the true relationship between chronic widespread pain and cortisol levels in patients with fibromyalgia.
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spelling pubmed-76980322020-11-29 Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis Úbeda-D’Ocasar, Edurne Jiménez Díaz-Benito, Victor Gallego-Sendarrubias, Gracia María Valera-Calero, Juan Antonio Vicario-Merino, Ángel Hervás-Pérez, Juan Pablo Diagnostics (Basel) Review This systematic review and meta-analysis sought to gain further insight into the relationship between cortisol reactivity and chronic widespread pain in patients with fibromyalgia. The studies selected were those conducted in adults with fibromyalgia that were random controlled, non-controlled or observational. Studies were excluded if they examined diseases other than fibromyalgia or if they did not report on pain or cortisol. Twelve studies met inclusion criteria. Data were extracted into tabular format using predefined data fields by two reviewers and assessed for accuracy by a third reviewer. The methodological quality of the studies was assessed using the PEDro scale. Data Synthesis: Of 263 studies identified, 12 were selected for our review and 10 were finally included as their methodological quality was good. In the meta-analysis, we calculated effect sizes of interventions on pain indicators and cortisol levels in patients with fibromyalgia. A small overall effect of all the interventions was observed on pain tolerance and pressure pain thresholds, yet this effect lacked significance (ES = 0.150; 95%CI 0.932–1.550; p > 0.05). Conclusions: While some effects of individual nonpharmacological therapeutic interventions were observed on both cortisol levels and measures of pain, our results suggest much further work is needed to elucidate the true relationship between chronic widespread pain and cortisol levels in patients with fibromyalgia. MDPI 2020-11-09 /pmc/articles/PMC7698032/ /pubmed/33182522 http://dx.doi.org/10.3390/diagnostics10110922 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Úbeda-D’Ocasar, Edurne
Jiménez Díaz-Benito, Victor
Gallego-Sendarrubias, Gracia María
Valera-Calero, Juan Antonio
Vicario-Merino, Ángel
Hervás-Pérez, Juan Pablo
Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis
title Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis
title_full Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis
title_fullStr Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis
title_full_unstemmed Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis
title_short Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis
title_sort pain and cortisol in patients with fibromyalgia: systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698032/
https://www.ncbi.nlm.nih.gov/pubmed/33182522
http://dx.doi.org/10.3390/diagnostics10110922
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