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Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis
This systematic review and meta-analysis sought to gain further insight into the relationship between cortisol reactivity and chronic widespread pain in patients with fibromyalgia. The studies selected were those conducted in adults with fibromyalgia that were random controlled, non-controlled or ob...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698032/ https://www.ncbi.nlm.nih.gov/pubmed/33182522 http://dx.doi.org/10.3390/diagnostics10110922 |
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author | Úbeda-D’Ocasar, Edurne Jiménez Díaz-Benito, Victor Gallego-Sendarrubias, Gracia María Valera-Calero, Juan Antonio Vicario-Merino, Ángel Hervás-Pérez, Juan Pablo |
author_facet | Úbeda-D’Ocasar, Edurne Jiménez Díaz-Benito, Victor Gallego-Sendarrubias, Gracia María Valera-Calero, Juan Antonio Vicario-Merino, Ángel Hervás-Pérez, Juan Pablo |
author_sort | Úbeda-D’Ocasar, Edurne |
collection | PubMed |
description | This systematic review and meta-analysis sought to gain further insight into the relationship between cortisol reactivity and chronic widespread pain in patients with fibromyalgia. The studies selected were those conducted in adults with fibromyalgia that were random controlled, non-controlled or observational. Studies were excluded if they examined diseases other than fibromyalgia or if they did not report on pain or cortisol. Twelve studies met inclusion criteria. Data were extracted into tabular format using predefined data fields by two reviewers and assessed for accuracy by a third reviewer. The methodological quality of the studies was assessed using the PEDro scale. Data Synthesis: Of 263 studies identified, 12 were selected for our review and 10 were finally included as their methodological quality was good. In the meta-analysis, we calculated effect sizes of interventions on pain indicators and cortisol levels in patients with fibromyalgia. A small overall effect of all the interventions was observed on pain tolerance and pressure pain thresholds, yet this effect lacked significance (ES = 0.150; 95%CI 0.932–1.550; p > 0.05). Conclusions: While some effects of individual nonpharmacological therapeutic interventions were observed on both cortisol levels and measures of pain, our results suggest much further work is needed to elucidate the true relationship between chronic widespread pain and cortisol levels in patients with fibromyalgia. |
format | Online Article Text |
id | pubmed-7698032 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76980322020-11-29 Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis Úbeda-D’Ocasar, Edurne Jiménez Díaz-Benito, Victor Gallego-Sendarrubias, Gracia María Valera-Calero, Juan Antonio Vicario-Merino, Ángel Hervás-Pérez, Juan Pablo Diagnostics (Basel) Review This systematic review and meta-analysis sought to gain further insight into the relationship between cortisol reactivity and chronic widespread pain in patients with fibromyalgia. The studies selected were those conducted in adults with fibromyalgia that were random controlled, non-controlled or observational. Studies were excluded if they examined diseases other than fibromyalgia or if they did not report on pain or cortisol. Twelve studies met inclusion criteria. Data were extracted into tabular format using predefined data fields by two reviewers and assessed for accuracy by a third reviewer. The methodological quality of the studies was assessed using the PEDro scale. Data Synthesis: Of 263 studies identified, 12 were selected for our review and 10 were finally included as their methodological quality was good. In the meta-analysis, we calculated effect sizes of interventions on pain indicators and cortisol levels in patients with fibromyalgia. A small overall effect of all the interventions was observed on pain tolerance and pressure pain thresholds, yet this effect lacked significance (ES = 0.150; 95%CI 0.932–1.550; p > 0.05). Conclusions: While some effects of individual nonpharmacological therapeutic interventions were observed on both cortisol levels and measures of pain, our results suggest much further work is needed to elucidate the true relationship between chronic widespread pain and cortisol levels in patients with fibromyalgia. MDPI 2020-11-09 /pmc/articles/PMC7698032/ /pubmed/33182522 http://dx.doi.org/10.3390/diagnostics10110922 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Úbeda-D’Ocasar, Edurne Jiménez Díaz-Benito, Victor Gallego-Sendarrubias, Gracia María Valera-Calero, Juan Antonio Vicario-Merino, Ángel Hervás-Pérez, Juan Pablo Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis |
title | Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis |
title_full | Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis |
title_fullStr | Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis |
title_full_unstemmed | Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis |
title_short | Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis |
title_sort | pain and cortisol in patients with fibromyalgia: systematic review and meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698032/ https://www.ncbi.nlm.nih.gov/pubmed/33182522 http://dx.doi.org/10.3390/diagnostics10110922 |
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