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Impact of Palliative Care in Evaluating and Relieving Symptoms in Patients with Advanced Cancer. Results from the DEMETRA Study

Background: Cancer patients experience multiple symptoms throughout the course of the disease. We aimed to provide a comprehensive analysis of the symptom burden in patients with advanced cancer at admission to specialist palliative care (PC) services and seven days later to estimate the immediate i...

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Autores principales: Corli, Oscar, Pellegrini, Giacomo, Bosetti, Cristina, Riva, Luca, Crippa, Matteo, Amodio, Emanuele, Scaccabarozzi, Gianlorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698052/
https://www.ncbi.nlm.nih.gov/pubmed/33202542
http://dx.doi.org/10.3390/ijerph17228429
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author Corli, Oscar
Pellegrini, Giacomo
Bosetti, Cristina
Riva, Luca
Crippa, Matteo
Amodio, Emanuele
Scaccabarozzi, Gianlorenzo
author_facet Corli, Oscar
Pellegrini, Giacomo
Bosetti, Cristina
Riva, Luca
Crippa, Matteo
Amodio, Emanuele
Scaccabarozzi, Gianlorenzo
author_sort Corli, Oscar
collection PubMed
description Background: Cancer patients experience multiple symptoms throughout the course of the disease. We aimed to provide a comprehensive analysis of the symptom burden in patients with advanced cancer at admission to specialist palliative care (PC) services and seven days later to estimate the immediate impact of PC intervention. Patient and methods: The analysis was based on an observational, prospective, multicenter study (named DEMETRA) conducted in Italy on new patients accessing network specialist PC centers during the period May 2017–November 2017. The prevalence and intensity of symptoms were assessed at baseline and after seven days using three tools including the Edmonton Symptom Assessment System (ESAS). Results: Five PC centers recruited 865 cancer patients. Thirty-three different symptoms were observed at the baseline, the most frequent being asthenia (84.9%) and poor well-being (71%). The intensity of the most frequent symptoms according to ESAS ranged from 5.5 for asthenia to 3.9 for nausea. The presence and intensity of physical symptoms increased with increasing levels of anxiety and depression. After seven days, prevalence of nausea and breathlessness as well as intensity of almost all symptoms significantly decreased. Conclusions: The study confirmed the considerable symptom burden of patients with advanced cancer. PC intervention has significantly reduced the severity of symptoms, despite the patients’ advanced disease and short survival.
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spelling pubmed-76980522020-11-29 Impact of Palliative Care in Evaluating and Relieving Symptoms in Patients with Advanced Cancer. Results from the DEMETRA Study Corli, Oscar Pellegrini, Giacomo Bosetti, Cristina Riva, Luca Crippa, Matteo Amodio, Emanuele Scaccabarozzi, Gianlorenzo Int J Environ Res Public Health Article Background: Cancer patients experience multiple symptoms throughout the course of the disease. We aimed to provide a comprehensive analysis of the symptom burden in patients with advanced cancer at admission to specialist palliative care (PC) services and seven days later to estimate the immediate impact of PC intervention. Patient and methods: The analysis was based on an observational, prospective, multicenter study (named DEMETRA) conducted in Italy on new patients accessing network specialist PC centers during the period May 2017–November 2017. The prevalence and intensity of symptoms were assessed at baseline and after seven days using three tools including the Edmonton Symptom Assessment System (ESAS). Results: Five PC centers recruited 865 cancer patients. Thirty-three different symptoms were observed at the baseline, the most frequent being asthenia (84.9%) and poor well-being (71%). The intensity of the most frequent symptoms according to ESAS ranged from 5.5 for asthenia to 3.9 for nausea. The presence and intensity of physical symptoms increased with increasing levels of anxiety and depression. After seven days, prevalence of nausea and breathlessness as well as intensity of almost all symptoms significantly decreased. Conclusions: The study confirmed the considerable symptom burden of patients with advanced cancer. PC intervention has significantly reduced the severity of symptoms, despite the patients’ advanced disease and short survival. MDPI 2020-11-14 2020-11 /pmc/articles/PMC7698052/ /pubmed/33202542 http://dx.doi.org/10.3390/ijerph17228429 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Corli, Oscar
Pellegrini, Giacomo
Bosetti, Cristina
Riva, Luca
Crippa, Matteo
Amodio, Emanuele
Scaccabarozzi, Gianlorenzo
Impact of Palliative Care in Evaluating and Relieving Symptoms in Patients with Advanced Cancer. Results from the DEMETRA Study
title Impact of Palliative Care in Evaluating and Relieving Symptoms in Patients with Advanced Cancer. Results from the DEMETRA Study
title_full Impact of Palliative Care in Evaluating and Relieving Symptoms in Patients with Advanced Cancer. Results from the DEMETRA Study
title_fullStr Impact of Palliative Care in Evaluating and Relieving Symptoms in Patients with Advanced Cancer. Results from the DEMETRA Study
title_full_unstemmed Impact of Palliative Care in Evaluating and Relieving Symptoms in Patients with Advanced Cancer. Results from the DEMETRA Study
title_short Impact of Palliative Care in Evaluating and Relieving Symptoms in Patients with Advanced Cancer. Results from the DEMETRA Study
title_sort impact of palliative care in evaluating and relieving symptoms in patients with advanced cancer. results from the demetra study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698052/
https://www.ncbi.nlm.nih.gov/pubmed/33202542
http://dx.doi.org/10.3390/ijerph17228429
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