Cardiac ECM: Its Epigenetic Regulation and Role in Heart Development and Repair

The extracellular matrix (ECM) is the non-cellular component in the cardiac microenvironment, and serves essential structural and regulatory roles in establishing and maintaining tissue architecture and cellular function. The patterns of molecular and biochemical ECM alterations in developing and ad...

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Detalles Bibliográficos
Autores principales: Song, Rui, Zhang, Lubo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698074/
https://www.ncbi.nlm.nih.gov/pubmed/33203135
http://dx.doi.org/10.3390/ijms21228610
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author Song, Rui
Zhang, Lubo
author_facet Song, Rui
Zhang, Lubo
author_sort Song, Rui
collection PubMed
description The extracellular matrix (ECM) is the non-cellular component in the cardiac microenvironment, and serves essential structural and regulatory roles in establishing and maintaining tissue architecture and cellular function. The patterns of molecular and biochemical ECM alterations in developing and adult hearts depend on the underlying injury type. In addition to exploring how the ECM regulates heart structure and function in heart development and repair, this review conducts an inclusive discussion of recent developments in the role, function, and epigenetic guidelines of the ECM. Moreover, it contributes to the development of new therapeutics for cardiovascular disease.
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spelling pubmed-76980742020-11-29 Cardiac ECM: Its Epigenetic Regulation and Role in Heart Development and Repair Song, Rui Zhang, Lubo Int J Mol Sci Review The extracellular matrix (ECM) is the non-cellular component in the cardiac microenvironment, and serves essential structural and regulatory roles in establishing and maintaining tissue architecture and cellular function. The patterns of molecular and biochemical ECM alterations in developing and adult hearts depend on the underlying injury type. In addition to exploring how the ECM regulates heart structure and function in heart development and repair, this review conducts an inclusive discussion of recent developments in the role, function, and epigenetic guidelines of the ECM. Moreover, it contributes to the development of new therapeutics for cardiovascular disease. MDPI 2020-11-15 /pmc/articles/PMC7698074/ /pubmed/33203135 http://dx.doi.org/10.3390/ijms21228610 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Song, Rui
Zhang, Lubo
Cardiac ECM: Its Epigenetic Regulation and Role in Heart Development and Repair
title Cardiac ECM: Its Epigenetic Regulation and Role in Heart Development and Repair
title_full Cardiac ECM: Its Epigenetic Regulation and Role in Heart Development and Repair
title_fullStr Cardiac ECM: Its Epigenetic Regulation and Role in Heart Development and Repair
title_full_unstemmed Cardiac ECM: Its Epigenetic Regulation and Role in Heart Development and Repair
title_short Cardiac ECM: Its Epigenetic Regulation and Role in Heart Development and Repair
title_sort cardiac ecm: its epigenetic regulation and role in heart development and repair
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698074/
https://www.ncbi.nlm.nih.gov/pubmed/33203135
http://dx.doi.org/10.3390/ijms21228610
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AT zhanglubo cardiacecmitsepigeneticregulationandroleinheartdevelopmentandrepair

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