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Clinical Characteristics and Survival Analysis in a Small Sample of Older COVID-19 Patients with Defined 60-Day Outcome

The older population is one of the most vulnerable to experience adverse outcomes of COVID-19. Exploring different clinical features that may act as detrimental to this population’s survival is pivotal for recognizing the highest risk individuals for poor outcome. We thus aimed to characterize the c...

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Autores principales: Neumann-Podczaska, Agnieszka, Chojnicki, Michal, Karbowski, Lukasz M., Al-Saad, Salwan R., Hashmi, Abbas A., Chudek, Jerzy, Tobis, Slawomir, Kropinska, Sylwia, Mozer-Lisewska, Iwona, Suwalska, Aleksandra, Tykarski, Andrzej, Wieczorowska-Tobis, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698090/
https://www.ncbi.nlm.nih.gov/pubmed/33198124
http://dx.doi.org/10.3390/ijerph17228362
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author Neumann-Podczaska, Agnieszka
Chojnicki, Michal
Karbowski, Lukasz M.
Al-Saad, Salwan R.
Hashmi, Abbas A.
Chudek, Jerzy
Tobis, Slawomir
Kropinska, Sylwia
Mozer-Lisewska, Iwona
Suwalska, Aleksandra
Tykarski, Andrzej
Wieczorowska-Tobis, Katarzyna
author_facet Neumann-Podczaska, Agnieszka
Chojnicki, Michal
Karbowski, Lukasz M.
Al-Saad, Salwan R.
Hashmi, Abbas A.
Chudek, Jerzy
Tobis, Slawomir
Kropinska, Sylwia
Mozer-Lisewska, Iwona
Suwalska, Aleksandra
Tykarski, Andrzej
Wieczorowska-Tobis, Katarzyna
author_sort Neumann-Podczaska, Agnieszka
collection PubMed
description The older population is one of the most vulnerable to experience adverse outcomes of COVID-19. Exploring different clinical features that may act as detrimental to this population’s survival is pivotal for recognizing the highest risk individuals for poor outcome. We thus aimed to characterize the clinical differences between 60-day survivors and non-survivors, as well as analyze variables influencing survival in the first older adults hospitalized in Poznan, Poland, with COVID-19. Symptoms, comorbidities, complications, laboratory results, and functional capacity regarding the first 50 older patients (≥60 years) hospitalized due to COVID-19 were retrospectively studied. Functional status before admission (dependent/independent) was determined based on medical history. The 60-day survivors (n = 30/50) and non-survivors (n = 20/50) were compared across clinical parameters. The patients had a mean age of 74.8 ± 9.4 years. Overall, 20/50 patients died during hospitalization, with no further fatal outcomes reported during the 60-day period. The non-survivors were on average older (78.3 ± 9.7 years), more commonly experienced concurrent heart disease (75%), and displayed functional dependence (65%) (p < 0.05). When assessing the variables influencing survival (age, heart disease, and functional dependence), using a multivariate proportional hazards regression, functional dependence (requiring assistance in core activities of daily living) was the main factor affecting 60-day survival (HR, 3.34; 95% CI: 1.29–8.63; p = 0.01). In our study, functional dependence was the most important prognostic factor associated with mortality. Elderly with COVID-19 who required assistance in core activities of daily living prior to hospitalization had a three times increased risk to experience mortality, as compared to those with complete independence. Exploring geriatric approaches, such as assessment of functional capacity, may assist in constructing comprehensive survival prognosis in the elderly COVID-19 population.
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spelling pubmed-76980902020-11-29 Clinical Characteristics and Survival Analysis in a Small Sample of Older COVID-19 Patients with Defined 60-Day Outcome Neumann-Podczaska, Agnieszka Chojnicki, Michal Karbowski, Lukasz M. Al-Saad, Salwan R. Hashmi, Abbas A. Chudek, Jerzy Tobis, Slawomir Kropinska, Sylwia Mozer-Lisewska, Iwona Suwalska, Aleksandra Tykarski, Andrzej Wieczorowska-Tobis, Katarzyna Int J Environ Res Public Health Article The older population is one of the most vulnerable to experience adverse outcomes of COVID-19. Exploring different clinical features that may act as detrimental to this population’s survival is pivotal for recognizing the highest risk individuals for poor outcome. We thus aimed to characterize the clinical differences between 60-day survivors and non-survivors, as well as analyze variables influencing survival in the first older adults hospitalized in Poznan, Poland, with COVID-19. Symptoms, comorbidities, complications, laboratory results, and functional capacity regarding the first 50 older patients (≥60 years) hospitalized due to COVID-19 were retrospectively studied. Functional status before admission (dependent/independent) was determined based on medical history. The 60-day survivors (n = 30/50) and non-survivors (n = 20/50) were compared across clinical parameters. The patients had a mean age of 74.8 ± 9.4 years. Overall, 20/50 patients died during hospitalization, with no further fatal outcomes reported during the 60-day period. The non-survivors were on average older (78.3 ± 9.7 years), more commonly experienced concurrent heart disease (75%), and displayed functional dependence (65%) (p < 0.05). When assessing the variables influencing survival (age, heart disease, and functional dependence), using a multivariate proportional hazards regression, functional dependence (requiring assistance in core activities of daily living) was the main factor affecting 60-day survival (HR, 3.34; 95% CI: 1.29–8.63; p = 0.01). In our study, functional dependence was the most important prognostic factor associated with mortality. Elderly with COVID-19 who required assistance in core activities of daily living prior to hospitalization had a three times increased risk to experience mortality, as compared to those with complete independence. Exploring geriatric approaches, such as assessment of functional capacity, may assist in constructing comprehensive survival prognosis in the elderly COVID-19 population. MDPI 2020-11-12 2020-11 /pmc/articles/PMC7698090/ /pubmed/33198124 http://dx.doi.org/10.3390/ijerph17228362 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Neumann-Podczaska, Agnieszka
Chojnicki, Michal
Karbowski, Lukasz M.
Al-Saad, Salwan R.
Hashmi, Abbas A.
Chudek, Jerzy
Tobis, Slawomir
Kropinska, Sylwia
Mozer-Lisewska, Iwona
Suwalska, Aleksandra
Tykarski, Andrzej
Wieczorowska-Tobis, Katarzyna
Clinical Characteristics and Survival Analysis in a Small Sample of Older COVID-19 Patients with Defined 60-Day Outcome
title Clinical Characteristics and Survival Analysis in a Small Sample of Older COVID-19 Patients with Defined 60-Day Outcome
title_full Clinical Characteristics and Survival Analysis in a Small Sample of Older COVID-19 Patients with Defined 60-Day Outcome
title_fullStr Clinical Characteristics and Survival Analysis in a Small Sample of Older COVID-19 Patients with Defined 60-Day Outcome
title_full_unstemmed Clinical Characteristics and Survival Analysis in a Small Sample of Older COVID-19 Patients with Defined 60-Day Outcome
title_short Clinical Characteristics and Survival Analysis in a Small Sample of Older COVID-19 Patients with Defined 60-Day Outcome
title_sort clinical characteristics and survival analysis in a small sample of older covid-19 patients with defined 60-day outcome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698090/
https://www.ncbi.nlm.nih.gov/pubmed/33198124
http://dx.doi.org/10.3390/ijerph17228362
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