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Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer’s Disease Model Mice

Centella asiatica (CA) is an edible plant and a popular botanical dietary supplement. It is reputed, in Ayurveda, to mitigate age-related cognitive decline. There is a considerable body of preclinical literature supporting CA’s ability to improve learning and memory. This study evaluated the contrib...

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Autores principales: Matthews, Donald G., Caruso, Maya, Alcazar Magana, Armando, Wright, Kirsten M., Maier, Claudia S., Stevens, Jan F., Gray, Nora E., Quinn, Joseph F., Soumyanath, Amala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698091/
https://www.ncbi.nlm.nih.gov/pubmed/33202902
http://dx.doi.org/10.3390/nu12113488
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author Matthews, Donald G.
Caruso, Maya
Alcazar Magana, Armando
Wright, Kirsten M.
Maier, Claudia S.
Stevens, Jan F.
Gray, Nora E.
Quinn, Joseph F.
Soumyanath, Amala
author_facet Matthews, Donald G.
Caruso, Maya
Alcazar Magana, Armando
Wright, Kirsten M.
Maier, Claudia S.
Stevens, Jan F.
Gray, Nora E.
Quinn, Joseph F.
Soumyanath, Amala
author_sort Matthews, Donald G.
collection PubMed
description Centella asiatica (CA) is an edible plant and a popular botanical dietary supplement. It is reputed, in Ayurveda, to mitigate age-related cognitive decline. There is a considerable body of preclinical literature supporting CA’s ability to improve learning and memory. This study evaluated the contribution of CA’s triterpenes (TT), widely considered its active compounds, and caffeoylquinic acids (CQA) to the cognitive effects of CA water extract (CAW) in 5XFAD mice, a model of Alzheimer’s disease. 5XFAD mice were fed a control diet alone, or one containing 1% CAW or compound groups (TT, CQA, or TT + CQA) equivalent to their content in 1% CAW. Wild-type (WT) littermates received the control diet. Conditioned fear response (CFR) was evaluated after 4.5 weeks. Female 5XFAD controls showed no deficit in CFR compared to WT females, nor any effects from treatment. In males, CFR of 5XFAD controls was attenuated compared to WT littermates (p = 0.005). 5XFAD males receiving CQA or TT + CQA had significantly improved CFR (p < 0.05) compared to 5XFAD male controls. CFR did not differ between 5XFAD males receiving treatment diets and WT males. These data confirm a role for CQA in CAW’s cognitive effects.
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spelling pubmed-76980912020-11-29 Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer’s Disease Model Mice Matthews, Donald G. Caruso, Maya Alcazar Magana, Armando Wright, Kirsten M. Maier, Claudia S. Stevens, Jan F. Gray, Nora E. Quinn, Joseph F. Soumyanath, Amala Nutrients Communication Centella asiatica (CA) is an edible plant and a popular botanical dietary supplement. It is reputed, in Ayurveda, to mitigate age-related cognitive decline. There is a considerable body of preclinical literature supporting CA’s ability to improve learning and memory. This study evaluated the contribution of CA’s triterpenes (TT), widely considered its active compounds, and caffeoylquinic acids (CQA) to the cognitive effects of CA water extract (CAW) in 5XFAD mice, a model of Alzheimer’s disease. 5XFAD mice were fed a control diet alone, or one containing 1% CAW or compound groups (TT, CQA, or TT + CQA) equivalent to their content in 1% CAW. Wild-type (WT) littermates received the control diet. Conditioned fear response (CFR) was evaluated after 4.5 weeks. Female 5XFAD controls showed no deficit in CFR compared to WT females, nor any effects from treatment. In males, CFR of 5XFAD controls was attenuated compared to WT littermates (p = 0.005). 5XFAD males receiving CQA or TT + CQA had significantly improved CFR (p < 0.05) compared to 5XFAD male controls. CFR did not differ between 5XFAD males receiving treatment diets and WT males. These data confirm a role for CQA in CAW’s cognitive effects. MDPI 2020-11-13 /pmc/articles/PMC7698091/ /pubmed/33202902 http://dx.doi.org/10.3390/nu12113488 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Matthews, Donald G.
Caruso, Maya
Alcazar Magana, Armando
Wright, Kirsten M.
Maier, Claudia S.
Stevens, Jan F.
Gray, Nora E.
Quinn, Joseph F.
Soumyanath, Amala
Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer’s Disease Model Mice
title Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer’s Disease Model Mice
title_full Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer’s Disease Model Mice
title_fullStr Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer’s Disease Model Mice
title_full_unstemmed Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer’s Disease Model Mice
title_short Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer’s Disease Model Mice
title_sort caffeoylquinic acids in centella asiatica reverse cognitive deficits in male 5xfad alzheimer’s disease model mice
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698091/
https://www.ncbi.nlm.nih.gov/pubmed/33202902
http://dx.doi.org/10.3390/nu12113488
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