Cargando…

Comparative Review of the Responses of Listeria monocytogenes and Escherichia coli to Low pH Stress

Acidity is one of the principal physicochemical factors that influence the behavior of microorganisms in any environment, and their response to it often determines their ability to grow and survive. Preventing the growth and survival of pathogenic bacteria or, conversely, promoting the growth of bac...

Descripción completa

Detalles Bibliográficos
Autores principales: Arcari, Talia, Feger, Marie-Lucie, Guerreiro, Duarte N., Wu, Jialun, O’Byrne, Conor P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698193/
https://www.ncbi.nlm.nih.gov/pubmed/33187233
http://dx.doi.org/10.3390/genes11111330
_version_ 1783615773750591488
author Arcari, Talia
Feger, Marie-Lucie
Guerreiro, Duarte N.
Wu, Jialun
O’Byrne, Conor P.
author_facet Arcari, Talia
Feger, Marie-Lucie
Guerreiro, Duarte N.
Wu, Jialun
O’Byrne, Conor P.
author_sort Arcari, Talia
collection PubMed
description Acidity is one of the principal physicochemical factors that influence the behavior of microorganisms in any environment, and their response to it often determines their ability to grow and survive. Preventing the growth and survival of pathogenic bacteria or, conversely, promoting the growth of bacteria that are useful (in biotechnology and food production, for example), might be improved considerably by a deeper understanding of the protective responses that these microorganisms deploy in the face of acid stress. In this review, we survey the molecular mechanisms used by two unrelated bacterial species in their response to low pH stress. We chose to focus on two well-studied bacteria, Escherichia coli (phylum Proteobacteria) and Listeria monocytogenes (phylum Firmicutes), that have both evolved to be able to survive in the mammalian gastrointestinal tract. We review the mechanisms that these species use to maintain a functional intracellular pH as well as the protective mechanisms that they deploy to prevent acid damage to macromolecules in the cells. We discuss the mechanisms used to sense acid in the environment and the regulatory processes that are activated when acid is encountered. We also highlight the specific challenges presented by organic acids. Common themes emerge from this comparison as well as unique strategies that each species uses to cope with acid stress. We highlight some of the important research questions that still need to be addressed in this fascinating field.
format Online
Article
Text
id pubmed-7698193
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-76981932020-11-29 Comparative Review of the Responses of Listeria monocytogenes and Escherichia coli to Low pH Stress Arcari, Talia Feger, Marie-Lucie Guerreiro, Duarte N. Wu, Jialun O’Byrne, Conor P. Genes (Basel) Review Acidity is one of the principal physicochemical factors that influence the behavior of microorganisms in any environment, and their response to it often determines their ability to grow and survive. Preventing the growth and survival of pathogenic bacteria or, conversely, promoting the growth of bacteria that are useful (in biotechnology and food production, for example), might be improved considerably by a deeper understanding of the protective responses that these microorganisms deploy in the face of acid stress. In this review, we survey the molecular mechanisms used by two unrelated bacterial species in their response to low pH stress. We chose to focus on two well-studied bacteria, Escherichia coli (phylum Proteobacteria) and Listeria monocytogenes (phylum Firmicutes), that have both evolved to be able to survive in the mammalian gastrointestinal tract. We review the mechanisms that these species use to maintain a functional intracellular pH as well as the protective mechanisms that they deploy to prevent acid damage to macromolecules in the cells. We discuss the mechanisms used to sense acid in the environment and the regulatory processes that are activated when acid is encountered. We also highlight the specific challenges presented by organic acids. Common themes emerge from this comparison as well as unique strategies that each species uses to cope with acid stress. We highlight some of the important research questions that still need to be addressed in this fascinating field. MDPI 2020-11-11 /pmc/articles/PMC7698193/ /pubmed/33187233 http://dx.doi.org/10.3390/genes11111330 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Arcari, Talia
Feger, Marie-Lucie
Guerreiro, Duarte N.
Wu, Jialun
O’Byrne, Conor P.
Comparative Review of the Responses of Listeria monocytogenes and Escherichia coli to Low pH Stress
title Comparative Review of the Responses of Listeria monocytogenes and Escherichia coli to Low pH Stress
title_full Comparative Review of the Responses of Listeria monocytogenes and Escherichia coli to Low pH Stress
title_fullStr Comparative Review of the Responses of Listeria monocytogenes and Escherichia coli to Low pH Stress
title_full_unstemmed Comparative Review of the Responses of Listeria monocytogenes and Escherichia coli to Low pH Stress
title_short Comparative Review of the Responses of Listeria monocytogenes and Escherichia coli to Low pH Stress
title_sort comparative review of the responses of listeria monocytogenes and escherichia coli to low ph stress
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698193/
https://www.ncbi.nlm.nih.gov/pubmed/33187233
http://dx.doi.org/10.3390/genes11111330
work_keys_str_mv AT arcaritalia comparativereviewoftheresponsesoflisteriamonocytogenesandescherichiacolitolowphstress
AT fegermarielucie comparativereviewoftheresponsesoflisteriamonocytogenesandescherichiacolitolowphstress
AT guerreiroduarten comparativereviewoftheresponsesoflisteriamonocytogenesandescherichiacolitolowphstress
AT wujialun comparativereviewoftheresponsesoflisteriamonocytogenesandescherichiacolitolowphstress
AT obyrneconorp comparativereviewoftheresponsesoflisteriamonocytogenesandescherichiacolitolowphstress