Cargando…
Type 17 Immune Response Facilitates Progression of Inflammation and Correlates with Cognition in Stable Schizophrenia
Dysregulation of the type 17 immune pathway has already been considered in schizophrenia and we previously measured decreased sera values of interleukin (IL)-17 in early stages. We further explored the possible correlation of IL-17 systemic levels with proinflammatory cytokines and cognitive scores...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698203/ https://www.ncbi.nlm.nih.gov/pubmed/33182582 http://dx.doi.org/10.3390/diagnostics10110926 |
_version_ | 1783615776102547456 |
---|---|
author | Borovcanin, Milica M. Minic Janicijevic, Slavica Jovanovic, Ivan P. Gajovic, Nevena M. Jurisevic, Milena M. Arsenijevic, Nebojsa N. |
author_facet | Borovcanin, Milica M. Minic Janicijevic, Slavica Jovanovic, Ivan P. Gajovic, Nevena M. Jurisevic, Milena M. Arsenijevic, Nebojsa N. |
author_sort | Borovcanin, Milica M. |
collection | PubMed |
description | Dysregulation of the type 17 immune pathway has already been considered in schizophrenia and we previously measured decreased sera values of interleukin (IL)-17 in early stages. We further explored the possible correlation of IL-17 systemic levels with proinflammatory cytokines and cognitive scores and additionally analyzed the percentage of IL-17 producing lymphocytes in peripheral blood of patients with stable schizophrenia. We included 27 patients diagnosed with schizophrenia (F20), after a three-month stable depot antipsychotic therapy (risperidone or paliperidone) and 18 healthy control subjects. Positive and Negative Syndrome Scale of Schizophrenia and the Montreal-Cognitive Assessment (MoCA) were conducted. Sera concentrations of IL-17, IL-6, tumor necrosis factor alpha (TNF-α) and soluble ST2 receptor (sST2) were measured. Flow cytometry and Natural Killer (NK) and T cell analyses were done in 10 patients and 10 healthy controls. Moderate positive correlation was established between IL-17 and TNF-α (r = 0.640; p = 0.001), IL-17 and IL-6 (r = 0.514; p = 0.006), IL-17 and sST2 (r = 0.394; p = 0.042). Furthermore, a positive correlation between the serum levels of IL-17 and MoCA scores was observed, especially with visuospatial and executive functioning, as well as language functioning and delayed recall (p < 0.05). Significantly higher percentage of IL-17 producing CD56(+) NK cells was measured in peripheral blood of patients with schizophrenia in remission vs. healthy individuals (p = 0.001). The percentage of CD4(+) T cells and CD4(+) T cells that produce IL-17 was significantly increased in patients (p = 0.001). This study revealed the involvement of innate type 17 immune response in the progression of inflammation and this could be related to cognitive functioning in stable schizophrenia. |
format | Online Article Text |
id | pubmed-7698203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76982032020-11-29 Type 17 Immune Response Facilitates Progression of Inflammation and Correlates with Cognition in Stable Schizophrenia Borovcanin, Milica M. Minic Janicijevic, Slavica Jovanovic, Ivan P. Gajovic, Nevena M. Jurisevic, Milena M. Arsenijevic, Nebojsa N. Diagnostics (Basel) Article Dysregulation of the type 17 immune pathway has already been considered in schizophrenia and we previously measured decreased sera values of interleukin (IL)-17 in early stages. We further explored the possible correlation of IL-17 systemic levels with proinflammatory cytokines and cognitive scores and additionally analyzed the percentage of IL-17 producing lymphocytes in peripheral blood of patients with stable schizophrenia. We included 27 patients diagnosed with schizophrenia (F20), after a three-month stable depot antipsychotic therapy (risperidone or paliperidone) and 18 healthy control subjects. Positive and Negative Syndrome Scale of Schizophrenia and the Montreal-Cognitive Assessment (MoCA) were conducted. Sera concentrations of IL-17, IL-6, tumor necrosis factor alpha (TNF-α) and soluble ST2 receptor (sST2) were measured. Flow cytometry and Natural Killer (NK) and T cell analyses were done in 10 patients and 10 healthy controls. Moderate positive correlation was established between IL-17 and TNF-α (r = 0.640; p = 0.001), IL-17 and IL-6 (r = 0.514; p = 0.006), IL-17 and sST2 (r = 0.394; p = 0.042). Furthermore, a positive correlation between the serum levels of IL-17 and MoCA scores was observed, especially with visuospatial and executive functioning, as well as language functioning and delayed recall (p < 0.05). Significantly higher percentage of IL-17 producing CD56(+) NK cells was measured in peripheral blood of patients with schizophrenia in remission vs. healthy individuals (p = 0.001). The percentage of CD4(+) T cells and CD4(+) T cells that produce IL-17 was significantly increased in patients (p = 0.001). This study revealed the involvement of innate type 17 immune response in the progression of inflammation and this could be related to cognitive functioning in stable schizophrenia. MDPI 2020-11-10 /pmc/articles/PMC7698203/ /pubmed/33182582 http://dx.doi.org/10.3390/diagnostics10110926 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Borovcanin, Milica M. Minic Janicijevic, Slavica Jovanovic, Ivan P. Gajovic, Nevena M. Jurisevic, Milena M. Arsenijevic, Nebojsa N. Type 17 Immune Response Facilitates Progression of Inflammation and Correlates with Cognition in Stable Schizophrenia |
title | Type 17 Immune Response Facilitates Progression of Inflammation and Correlates with Cognition in Stable Schizophrenia |
title_full | Type 17 Immune Response Facilitates Progression of Inflammation and Correlates with Cognition in Stable Schizophrenia |
title_fullStr | Type 17 Immune Response Facilitates Progression of Inflammation and Correlates with Cognition in Stable Schizophrenia |
title_full_unstemmed | Type 17 Immune Response Facilitates Progression of Inflammation and Correlates with Cognition in Stable Schizophrenia |
title_short | Type 17 Immune Response Facilitates Progression of Inflammation and Correlates with Cognition in Stable Schizophrenia |
title_sort | type 17 immune response facilitates progression of inflammation and correlates with cognition in stable schizophrenia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698203/ https://www.ncbi.nlm.nih.gov/pubmed/33182582 http://dx.doi.org/10.3390/diagnostics10110926 |
work_keys_str_mv | AT borovcaninmilicam type17immuneresponsefacilitatesprogressionofinflammationandcorrelateswithcognitioninstableschizophrenia AT minicjanicijevicslavica type17immuneresponsefacilitatesprogressionofinflammationandcorrelateswithcognitioninstableschizophrenia AT jovanovicivanp type17immuneresponsefacilitatesprogressionofinflammationandcorrelateswithcognitioninstableschizophrenia AT gajovicnevenam type17immuneresponsefacilitatesprogressionofinflammationandcorrelateswithcognitioninstableschizophrenia AT jurisevicmilenam type17immuneresponsefacilitatesprogressionofinflammationandcorrelateswithcognitioninstableschizophrenia AT arsenijevicnebojsan type17immuneresponsefacilitatesprogressionofinflammationandcorrelateswithcognitioninstableschizophrenia |