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Salivary Stress/Immunological Markers in Crohn’s Disease and Ulcerative Colitis

There is continuous and growing interest in research into new alternatives to standard biomarkers to detect and follow-up disease, reducing physical and psychological stress in patients needing regular and invasive medical examinations for the evaluation of pathologies, including inflammatory bowel...

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Detalles Bibliográficos
Autores principales: Finamore, Alberto, Peluso, Ilaria, Cauli, Omar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698267/
https://www.ncbi.nlm.nih.gov/pubmed/33202858
http://dx.doi.org/10.3390/ijms21228562
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author Finamore, Alberto
Peluso, Ilaria
Cauli, Omar
author_facet Finamore, Alberto
Peluso, Ilaria
Cauli, Omar
author_sort Finamore, Alberto
collection PubMed
description There is continuous and growing interest in research into new alternatives to standard biomarkers to detect and follow-up disease, reducing physical and psychological stress in patients needing regular and invasive medical examinations for the evaluation of pathologies, including inflammatory bowel diseases (IBD). Saliva is one of the most promising body fluids in the research of new biomarkers, thanks to the large number of molecules it contains. Many molecules present in saliva are often directly correlated to their concentration in the blood but may be affected by the condition of the oral cavity. This means that a careful selection of a specific biomarker is required for each pathology, especially pathologies such as IBD, which may induce inflammation in the oral cavity. Here, we analyze the currently used and the proposed new salivary biomarkers (i.e., calprotectin, cytokines, IgA, cortisol, and oxidative stress markers) for the detection and follow-up of the main subtypes of IBD, known as ulcerative colitis and Crohn’s disease.
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spelling pubmed-76982672020-11-29 Salivary Stress/Immunological Markers in Crohn’s Disease and Ulcerative Colitis Finamore, Alberto Peluso, Ilaria Cauli, Omar Int J Mol Sci Review There is continuous and growing interest in research into new alternatives to standard biomarkers to detect and follow-up disease, reducing physical and psychological stress in patients needing regular and invasive medical examinations for the evaluation of pathologies, including inflammatory bowel diseases (IBD). Saliva is one of the most promising body fluids in the research of new biomarkers, thanks to the large number of molecules it contains. Many molecules present in saliva are often directly correlated to their concentration in the blood but may be affected by the condition of the oral cavity. This means that a careful selection of a specific biomarker is required for each pathology, especially pathologies such as IBD, which may induce inflammation in the oral cavity. Here, we analyze the currently used and the proposed new salivary biomarkers (i.e., calprotectin, cytokines, IgA, cortisol, and oxidative stress markers) for the detection and follow-up of the main subtypes of IBD, known as ulcerative colitis and Crohn’s disease. MDPI 2020-11-13 /pmc/articles/PMC7698267/ /pubmed/33202858 http://dx.doi.org/10.3390/ijms21228562 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Finamore, Alberto
Peluso, Ilaria
Cauli, Omar
Salivary Stress/Immunological Markers in Crohn’s Disease and Ulcerative Colitis
title Salivary Stress/Immunological Markers in Crohn’s Disease and Ulcerative Colitis
title_full Salivary Stress/Immunological Markers in Crohn’s Disease and Ulcerative Colitis
title_fullStr Salivary Stress/Immunological Markers in Crohn’s Disease and Ulcerative Colitis
title_full_unstemmed Salivary Stress/Immunological Markers in Crohn’s Disease and Ulcerative Colitis
title_short Salivary Stress/Immunological Markers in Crohn’s Disease and Ulcerative Colitis
title_sort salivary stress/immunological markers in crohn’s disease and ulcerative colitis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698267/
https://www.ncbi.nlm.nih.gov/pubmed/33202858
http://dx.doi.org/10.3390/ijms21228562
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